Sentences with phrase «impacts on cell»

These changes have their own impacts on cell response, making it difficult to identify the effects of the drug alone.

Good source of vitamin A and antioxidants all protecting you from free radicals which can have a negative impact on cells.

Focusing on energy - transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically - approved drug stiripentol, 3 natural products — caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid — and experimental pharmaceuticals, such as actinonin, FK866 and 2 - DG.

The study found that combining the two drugs had an increased effect of killing of cancer cells, while individually, the drugs have considerably less impact on cell viability.

«We're seeing that some of these factors have a major impact on cell behavior that is not possible to observe in conventional 2D cell cultures.»

Researchers at the University of Edinburgh and the MRC Laboratory for Molecular Biology in Cambridge used molecular analysis to find that concentrations of magnesium rose and fell in a 24 - hour cycle in all cell types, and that this impacts on the cells» internal clocks.

Thus, CXCR4 disruption had no impact on cell viability, but conferred a significant survival advantage in the presence of HIV strains that can use CXCR4 to infect cells.

One of the first analyses of laws banning disposal of electronic waste (e-waste) in municipal landfills has found that state e-waste recycling bans have been mostly ineffective, although California's Cell Phone Recycling Act had a positive impact on cell phone recycling.

For subsequent experiments we used an MOI of 600 as this provided near - maximal disruption efficiency with limited impact on cell growth.

Alternatively, evolutionary approaches have been used to identify functional regions as those that are likely to have a measurable biological impact on cell function if perturbed.

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

«Overexpression of aquaporin has no negative impact on cells because it is exclusive to water and simply allows the molecules to go back and forth across the cell membrane,» Shapiro says.

Touchstone - P was inspired by the Broad Institute's Connectivity Map (CMap), which catalogs drugs» impacts on cells» gene expression.

treatment with the antioxidant NAC impairs the accumulation of ROS with no impact on cell viability

Baked goods have saturated trans - fats which have a negative impact on our cells, along with the immune system.

Transforming our subtle energy field in this way has a direct and immediate impact on our cells, our physical body, and our health.

They also tend to smile more, be friendlier, and because their brains are better equipped to deal with stress, there is less silent impact on their cells (i.e. inflammation, oxidation / free radical damage), and therefore their outward appearance is more naturally beautiful.

Not exact matches

Unlike some of the promising treatments that have failed in 2017 that deal with the so - called «amyloid hypothesis» (the treatments target amyloid beta deposits in the brain that accumulate in people with Alzheimer's disease), approaches that try to prevent nerve cells from dying wouldn't have any impact on that buildup.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«The event, the fourth of its kind, seeks to raise global awareness and create a forum for collaboration around the wide array of powerful and promising cell therapies, gene therapies, and immunotherapies emerging from medical institutions around the world, as well as the impact new technology will have on humanity and society,» a press release by the Cure Foundation explains (h / t Christian Post).

As we read this history, the furor over stem cells was fueled by numerous factors: the near - universal human desire for magic; patients» desperation in the face of illness and their hope for cures; the belief that biology can now do anything; the reluctance of scientists to accept any limits (particularly moral limits) on their research; the impact of big money from biotech stocks, patents, and federal funding; the willingness of America's elite class to use every means possible to discredit religion in general; and the need to protect the unlimited abortion license by accepting no protections of unborn human life.

The beliefs of others impact even non-believers lives through the laws that they promote, e.g. bans on gay marriage, creationism in science class, reduced stem - cell research, abstinence only se.x ed., etc., etc..

As members of society, the way that we act has the ability to impact others in big ways (global warming, racism) and in small ways (person talking on cell phone during a movie, smoker blowing smoke in your face as they pass you on the sidewalk).

On top of this, it has Safecell impact protection with a steel cell and energy - absorbing base, and 3 layers of side impact protection.

Once you are clear about those questions, you can set some rules around phone use, so that your child's cell phone doesn't have a negative impact on the existing routines in your home.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

The vote will have little direct impact on human embryonic stem cell research, but the potential threat to reproductive technology and abortion rights is more immediate

Ageing is a complicated process, involving DNA damage, chronic inflammation, and worn - out cells, but we don't yet know which of these has the biggest impact on ageing.

Now, the team has examined whether sepsis has the same impact on tissue resident memory T cells (TRM), which do not circulate but stick to the skin, lungs, and gut — where infections often enter the body.

This is a new era where we are now able to test whether a dose of stem cells delivered directly to the injured site can have an impact on motor or sensory function,» says Fessler.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

It will also depend on the success of competing emission - free technologies — solar, wind, biomass, and fuel cell energy, among others — that promise less environmental impact.

Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug.

One area of research within mechanobiology, the study of how physical forces influence biological processes, is on the interplay between cells and their environment and how it impacts their ability to grow and spread.

They impact on signal transmission from cell to cell, but also affect intracellular communication,» explains Professor Robert Ernst, whose research group at the BMLS has been on the trail of fats» hidden functions for years.

Which areas in the body are targeted by T cells and the impact they will have depends on various factors.

Hindson adds that even seemingly simple issues, such as how the cells are isolated and stored before sequencing, can have a major impact on the quality of the data.

«The next step of progress is to use this knowledge to decipher what potential impact the genetic variants can have on the health of individuals, when we conduct health - related research,» added Professor Michael Pepper, Unit Director of the South African Medical Research Council's (SAMRC) Stem Cell Research and Therapy Unit, Faculty of Health Sciences at the University of Pretoria.

He's also looking at the impact on the ability of trabecular meshwork cells to make and send out fluid - filled pockets called exosomes that may enable the cells to communicate.

The investigators utilized a targeting method called RNA interference (RNAi) which, when delivered via these natural nanoparticles or exosomes, zero in on mutant KRAS in pancreas cancer cells, impacting tumor burden and survival in multiple pancreas cancer models.

Now, they are also are looking at the impact on the trabecular meshwork cells» ability to take up aqueous humor and deliver it back to the circulation.

Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs

Carbon nanotubes (left), quantum dots (inside cells, right), and nanoparticles show promise for many uses, but little is known about their impact on human health and the environment.

Another key finding of the research was that the impact of vitamin D on inflammatory disease can not be predicted using cells from healthy individuals or even from the blood of patients with inflammation as cells from the disease tissue are very different.

Findings based on this new technology are likely to have a significant impact on basic cellular research and increase our knowledge of how cells work and respond to stresses, such as exposure to contamination.

Findings based on this new technology are likely to have a profound impact on improving the detection and diagnosis of diseased cells and in evaluating a patient's response to chemotherapy.

Examining the impact of cell phone conversations on driving using meta - analytic techniques.

He examined the direct impact of the substance on neural effects using tests involving brain cells.

Inhibiting the protein in astrocytes had no impact on disease progression, so the search for the weapons that cell type uses against motor neurons continues.

Its scientists recently earned an award for the development of a Wavelength Scanning Interferometer, which has uses that include the detection of defects in the coating that can have a serious impact on the longevity of roll - to - roll vapour barrier coatings for flexible PV (photovoltaic) cells.