«Finding the link between
motility and autophagy in the intestine will require further research, but we speculate that inhibiting autophagy in the
gut may
impair the
gut's ability to metabolize nutrients or secrete hormones important for the function of other organs.»
A maladapted stress response is thought to contribute to IBS flares through several mechanisms, including
impaired gut barrier function, changes in
gut flora, changes in gastrointestinal
motility and secretion, decreased mucosal blood flow, and decreased ability to heal and recover from damage.