Sentences with phrase «impaired cell survival»

When introduced into the MDA - MB - 231 cells, the Δ2A mutant did not induce apoptosis of these cells whereas WT LARP7 readily impaired cell survival, supporting the model that the ability of LARP7 to assemble 7SK snRNP and suppress P - TEFb is necessary for its tumor suppressor potential.

Not exact matches

The study «Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation» is published in the journal Scientific Reports.

By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

Our work aims to investigate mechanistically the molecular processes through which dysregulation of factors controlling oxidative stress impairs RPE and photoreceptor cell metabolism and their survival in AMD.

ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival.

Importantly, when mice received lethal doses of host - type acute leukemia cells, administration of VPA did not impair GVL activity and resulted in significantly improved leukemia - free survival.

Patients with Hematological Diseases / Red Cell Disorders Patients with red cell disorders that impair the function of survival of the red cells are in general not accepted as volunteer blood donors but can be eligible for a «therapeutic phlebotomy» (for example, patients with Polycytemia VeCell Disorders Patients with red cell disorders that impair the function of survival of the red cells are in general not accepted as volunteer blood donors but can be eligible for a «therapeutic phlebotomy» (for example, patients with Polycytemia Vecell disorders that impair the function of survival of the red cells are in general not accepted as volunteer blood donors but can be eligible for a «therapeutic phlebotomy» (for example, patients with Polycytemia Vera).

Interestingly, the LARP7 - overexpressing cells formed significantly fewer colonies than those harboring the control vector (Figure 7D), suggest that re-expression of LARP7 impairs survival of these metastatic breast cancer cells.