Dr. Llovet and colleagues demonstrated that the expression of mutant IDH in the adult liver of genetically engineered mice
impairs liver cell
development and liver regeneration — a process in which the liver responds to injury — and increases the number of cells to form a
tumor.
Her research may lead to improved diagnostic tools and also facilitate the
development of novel cancer therapies that prevent
tumor recruitment of macrophages and, as a result,
impair a cancer's ability to metastasize.