Not exact matches
That's because, in theory, thanks to that single wisp of intermediate
code, the
genes implicated in many diseases should be easier to quiet.
The two
genes implicated — GNAQ and GNA11 —
code for proteins (known as G proteins) that normally function as molecular on - off switches, regulating the passage of information from the outside to the inside of a cell.
«Instead of looking solely at the
genes directly
implicated in autism through their genetic
code changes, we really should be also studying the functions of the other
genes implicated by these changes in genetic
code through epigenetic connections.»
Several genetic variations were discovered in
genes that are suspected to play a role in drug resistance, notably those that
code transporter proteins and those
implicated in DNA repair.
However, since most of the disease variants fall outside the
gene coding sequences, thereby
implicating gene expression regulation as the causal mechanism, the functional interpretation of the exact role of the associated variants remains to be determined.
Our study may
implicate haploinsufficiency of protein -
coding genes as a general mechanism of aging of the hematopoietic system and of aging - associated disorders more generally and provide new insights into the genetics of aging and healthspan.