Diet and lifestyle are
implicated in some diseases - smoking related cancers, high fat and sugar diets with diabetes and heart disease, alcohol and liver disease, vitamin D deficiency with rickets, gluten and coeliac, fava beans in G6PD, folic acid and NTD etc..
Some argued that the genes
implicated in the disease promoted creativity; others believed that schizophrenics were frustrated cult leaders — unorthodox thinkers constitutionally «engineered» to lead segments of humanity to break off from the herd, but who lacked the charisma to effect much change.
An analysis of the peptide's structure in semen indicated that it hooked up with similar fragments to create amyloid fibers (clusters of protein fragments that have also been
implicated in diseases such as Alzheimer's).
Different proteins are
implicated in each disease: tau in Alzheimer's, alpha - synuclein in Parkinson's and huntingtin in Huntington's disease.
Today, though, they may be
implicated in diseases like obesity, diabetes, high blood pressure, and heart disease.
JUDY MIKOVITS HAD BEEN SO COCOONED IN the world of AIDS that she had never heard of chronic fatigue syndrome until 2006, when she was hired to consult for a Santa Barbara — based foundation supporting investigation into human herpes virus six (HHV6), which had been
implicated in the disease.
This is the first time these mineral deposits have been
implicated in the disease, which affects more than 10 million Americans.
Is oxidized mRNA
implicated in disease?
The study could help identify people who would most benefit from new drugs designed to save brain cells, but more research is necessary to determine if the genetic mutations are
implicated in disease.
Zhou's team will coax ES cells to develop into precursors to neurons, and will then inject them into the striatum, a central region of the brain
implicated in the disease.
Professor Hayday added: «This is very significant because antibodies make up one of the largest sectors of the pharmaceutical market, and one of the great quests in the pharmaceutical industry is to be able to routinely generate antibodies against human proteins
implicated in diseases.
Today, though, these fatty acids are also
implicated in diseases that are part of the so - called «metabolic syndrome» — obesity, diabetes (through the metabolism of sugars), high blood pressure, and cardiovascular disease (through the metabolism of cholesterol and triglycerides), the authors say.
While abnormally short telomeres have been
implicated in some diseases, studies investigating whether longer telomeres lead to a longer life have shown mixed results.
«A three - dimensional map of the genome: Gene mapping technique promises to unlock the power of proximity to find genes
implicated in diseases.»
Target - based strategies typically employ in vitro high - throughput screening methods to identify small molecules that alter the activity of an identified candidate protein
implicated in a disease process.
Our goal is, through the greater understanding of pathological mechanisms
implicated in this disease, to identify new therapeutic strategies for this neuromuscular disease and to extend this experimental approach to other neuromuscular diseases.
Some of these proteins already have been
implicated in diseases such as cancer, but only a minority were previously known to be «druggable.»
Following cohort recruitment, creation of the bio-bank and population of the database, the pathogen discovery and pathogenesis study led by the Center for Infection and Immunity at Columbia University seeks to uncover novel viruses
implicated in the disease by using techniques that allow up to 20 pathogens to be searched simultaneously.
We study the maturation enzymes known as proprotein convertases, responsible for generating most secreted signaling proteins, and
implicated in diseases such as diabetes, obesity, bone disease, and cancer.
There are still kinks to work out, Liu notes — once the proteins get inside the cell, many get stuck and can't reach their targets — but this strategy has the potential to deliver monoclonal antibodies or other large proteins directly to intracellular pathways
implicated in disease.
Dr. Mucke expects that an effective Alzheimer's solution will include multiple therapies to address the numerous proteins
implicated in the disease — including amyloid - beta, apoE4 and tau — in much the same way that hypertension, cancer and severe infections often require treatment with combinations of different remedies.
Research interests focus around abnormalities and defects of the immune system
implicated in disease.
Both Krogan and Kreitzer hope to develop more focused treatments that target the specific proteins or neurons
implicated in disease.
Many genes are
implicated in those diseases in humans, but it's often hard to tell which ones actually cause the disease and which are merely associated with it somehow.
Infections of the teeth and gums have long been
implicated in diseases of the kidneys (as well as the heart) in both animals and humans.
Not exact matches
That's because,
in theory, thanks to that single wisp of intermediate code, the genes
implicated in many
diseases should be easier to quiet.
Dark chocolate is rich
in antioxidants (specifically cocoa polyphenols), which can help to combat free radicals, destructive molecules that are
implicated in heart
disease and other ailments.
The science actually led to the conclusion that refined sugar is
implicated in heart
disease and cancer.
Dark chocolate is a potent antioxidant and antioxidants gobble up free radicals, destructive molecules that are
implicated in heart
disease and other ailments.
This current study conducted
in Nigeria looked at the pathogenic role of cadmium (Cd) and its exposure
in the induction of dyslipidemia
implicated in the development and increasing incidence of cardiovascular
diseases, and explored whether polyphenolics isolated from virgin coconut oil (VCO) could prevent Cd - induced dyslipidemia.
A2 Corp claimed the beta casein A1 found
in most cows» milk sold
in New Zealand had been linked with the development of coronary heart
disease, childhood diabetes and also
implicated in autism and schizophrenia.
In modern day Sri Lanka, Cardiovascular
Disease (CVD) is the leading cause of death among adults, and coconut oil is usually
implicated as a reason for this high rate of CVD.
(Studies have linked loss of smell to the same neurotransmitters
implicated in age - related
diseases like Parkinson's and Alzheimer's.)
Ironically, early introduction of formula and a diet of «junk» food are both
implicated in increasing the incidence of
diseases such as diabetes and obesity.
Or that an anti-hunger charity has partnered with two major suppliers of refined sugar, which has been directly
implicated in rising rates of childhood obesity, diabetes and related chronic
diseases?
These and other food allergens
implicated in atopic
disease, such as egg and peanut, can be detected
in human breast milk 4 hours after maternal intake and remain
in the milk for several days (20).
In the study, whole - exome sequencing and a targeted analysis of 90 genes implicated in heart disease were applied to 419 unrelated SIDS case
In the study, whole - exome sequencing and a targeted analysis of 90 genes
implicated in heart disease were applied to 419 unrelated SIDS case
in heart
disease were applied to 419 unrelated SIDS cases.
«Cooling towers have been
implicated in several outbreaks of Legionnaire's
Disease in recent years.
McCallion's strategy to make sense of all this data looks at the active genes
in cells affected by a
disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for
disease risk down to just a handful within any one
implicated region.
Tsai's group manipulated the gene for the protein p25, which has been
implicated in several neurodegenerative
diseases, so that it could be easily switched on and off.
As soon as Aull decided to build her lab, she knew she would have to follow government safety protocols for a Biosafety Level 1 facility secure enough to handle well - known agents not
implicated in human
disease.
«Suppressing a progenitor from creating the subtype of dendritic cells
implicated in causing lupus, for example, could be an efficient way of treating autoimmune
diseases while minimising the impact on the rest of the immune system.
The molecule that shuttles proteins between the nucleus and cytoplasm, XPO1 (also called CRM1,) has been
implicated in multiple sclerosis and a number of other
diseases.
That arm of the antibody had been engineered to grab and block a protein called Beta - secretase, or bace1, which helps produce the plaques
implicated in Alzheimer's
disease.
The network provides an invaluable resource for identifying targets to treat the
disease and has been used to
implicate a particular signaling pathway involved
in cell motility.
Compared to eating earlier
in the day, prolonged delayed eating can increase weight, insulin and cholesterol levels, and negatively affect fat metabolism, and hormonal markers
implicated in heart
disease, diabetes and other health problems, according to results from researchers at the Perelman School of Medicine at the University of Pennsylvania.
This molecule, called interferon regulatory factor 1, has been found at abnormally high levels
in the gut linings of children with coeliac
disease, and has also been
implicated in instigating the condition's onset.
These genetic discoveries reinforce earlier gene studies
implicating abnormal inflammation and fat metabolism
in the
disease.
They have been
implicated in nerve degeneration
in Lou Gehrig's
disease, multiple sclerosis, and Parkinson's
disease.
For instance, alterations
in the composition of the bacterial community are
implicated in the origin of various so - called environmental
diseases.