Sentences with phrase «important brain gene»
The finding that an important brain gene has continued to evolve adaptively in anatomically modern humans suggests the ongoing evolutionary plasticity of the human brain.
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Early life stress, such as an extreme lack of parental affection, has lasting effects on a gene important to normal brain processes and is also tied to mental disorders.
Procured from algae, algal oil is source of DHA, an important long - chain omega - 3 that supports brain development, immune balance, and healthy gene expression.
Identifying genes that promote or prevent neuronal death would thus be an important step in understanding both developmentally - regulated neuronal death as well as the mechanisms underlying degenerative brain disorders.
Researchers have pinpointed a gene that keeps important brain cells in mice from crossing their wires, providing a possible link between brain wiring and mood disorders like depression.
The gene for NPAS4 was a top hit, and significant for an important reason: it is an early - onset gene, meaning that its effects could be exerted on the brain rapidly unless HDAC5 was there to inhibit it — just the molecular event Cowan and his team were seeking.
«Our work suggests that fine - tuning messenger stability is an important mechanism orchestrating gene expression changes during normal brain development.»
They found far more methylation in the orphans» genes, including many that play an important role in neural communication and brain development and function.
Nevertheless,» [the] study is very important because it demonstrates for the first time that we can use gene therapy to transform cells in the brain into ones that will secrete GDNF,» says Jeffrey Kordower, a professor of neurological sciences at Rush Presbyterian Medical Center in Chicago.
For any particular cell, such as a skin or brain cell, much of this genetic information is extraneous and must be packed away to allow sufficient space and resources for more important genes.
In mice, they deleted four ultraconserved elements — individually and in various combinations — that lie within regions of DNA that also contain genes important in brain development.
The gene may have been important for the evolution of big human brains.
Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.
First, looking at a study of 185 cases of childhood epilepsy, Wittkowski's team found that mutations in genes that control axonal guidance and calcium signaling — both of which are important early in the developing brain when neurons are forming the appropriate connections — led to increased chances of having the disorder.
Some evidence hints that duplicate enhancers may help control genes important in other parts of the brain.
«They help us to understand how the FOXP2 gene might have been important in the evolution of the human brain and direct us towards neural mechanisms that play a role in speech and language acquisition.»
Basel scientists have now identified a network of genes that controls fundamental properties of neurons and is important for human brain activity, memory and the development of schizophrenia.
In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.
«Important gene interaction defined that drives aggressive brain cancer.»
Preclinical studies suggest that Cdk5 is a gene that is important for the normal wiring of the brain during early development and may be involved in some neurodegenerative disorders, including ALS, Parkinson's and Alzheimer's disease.
«By looking comprehensively at gene expression within cells, we can now spot numerous important differences in complex tissues like the brain that are invisible today,» said George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School.
The Salk and TSRI scientists used a range of neuro - genetic, gene therapy, biochemical and structural biology research techniques to discover that the mutant GlyRS enzyme blocked molecular signals important for maintaining the health of motor neurons, the cells that carry messages from the brain to the muscles of the extremities.
But, fascinating anecdotes aside, does hard evidence exist of specific vulnerability genes or how they might impair the immune system, brain, and gut — and most important, do we have any rational, reliable approaches to help repair the damage?
The researchers determined that HARE5 likely controls a gene called Frizzled 8, which is part of a molecular pathway important in brain development.
«Everyone was focusing on genes expressed in the brain,» says Levitt, «but this gene is important for repair of the intestine and immune function.
It found that people with the variant of the GRM3 gene, thought to be important in brain signalling, were at increased risk of developing bipolar disorder, schizophrenia and alcohol dependence.
By revealing patterns of gene activity, the mouse atlas has allowed neuroscientists to identify functionally important regions that were invisible simply by looking at the brain's anatomy.
«Identifying gene variants that are general risk factors for neurological and psychiatric disease is important, but understanding exactly which cell types in the developing brain are compromised and what the consequences are is still extremely challenging,» Pollen added.
These differences were found in parts of the DNA that turn genes on and off in specific brain regions, in this case a brain region important for spatial memory.
When working properly, the two genes form the coupled protein and when something sweet enters the mouth the news is rushed to the brain, primarily because sweetness is a sign of rich carbohydrates — an important food source for plant - eaters and the nondiscriminating, like humans.
Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.
... The FOXP2 gene has been around for a very long time, found in similar form in distantly related vertebrate species, and it may be important not only for brain development and function but also in other tissues.»
Although variations in the NPAS1 and NPAS3 genes have been linked to brain disorders including autism, they aren't obvious drug targets because their function is most important in early life.
Some of the genes may be important in understanding the genetics behind disease as well as the evolution of the human brain.
For instance, says Korenberg, the data could help scientists to link genes that seem important in certain mental disorders, such as schizophrenia or autism, to specific brain - wiring abnormalities.
Asst Prof Li, from the Neural Stem Cells Laboratory at NNI, added, «This important study suggests a link between a key neurological disease gene and regulation of microRNAs in the brain.
The gene, known as C9ORF72, was only linked to dementia in the last five years so it's encouraging that advances are being made to piece together the important role it plays in the brain.»
In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.
Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.
The researchers, chiefly from the Broad Institute, Harvard Medical School and Boston Children's Hospital, found that a person's risk of schizophrenia is dramatically increased if they inherit variants of a gene important to «synaptic pruning» — the healthy reduction during adolescence of brain cell connections that are no longer needed.
A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.
14:53 - According to Dr Cattaneo, the normal HD gene seems to have important roles during the development of the brain
The presence of several mutations in four important genes for the brain's synapses can be associated to Obsessive Compulsive Disorder in humans.
An international team of scientists has now made a breakthrough by showing that many genes controlling the development of the brain and the nervous system were particularly important for rabbit domestication.
These types of mice have played important roles in helping us to learn about the function of the gene on the brain.
They found that compared to dengue infection, Zika infection more strongly affects expression of genes involved in DNA replication and repair, processes that are important in brain development.
It's important for artery and brain health, and when elevated, it may be due to a genetic defect in the MTHFR gene, which is also easily measured.
A recent study found enhanced expression of genes encoding for mitochondrial enzymes and energy metabolism in the hippocampus, a part of the brain important for learning and memory.
Procured from algae, algal oil is source of DHA, an important long - chain omega - 3 that supports brain development, immune balance, and healthy gene expression.
Finally, animal research focusing on brain - structural aspects related to early care and the new, conceptually important direction of studying environmental programming of early development through epigenetic modification of gene functioning is examined in brief.