Sentences with phrase «important causes of disease»

It is vital to be able to find these variants because they are an important cause of disease.

FeLV is an important cause of disease and death in cats.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

(Though it's important to note that the treatment, Mitsubishi Tanabe Pharma America's Radicava, is mightily expensive and only treats symptom progression rather than the root cause of the disease.)

For example, breakfast is not the most important meal of the day, working out for half an hour is more effective for weight loss than an hour and saturated fat doesn't cause heart disease.

As long ago as 1970, in The Patient as Person, one of the truly important books at the dawn of bioethics, Paul Ramsey argued that, in a healthy society dedicated to research aimed at the conquest of disease, we would all regard ourselves as «joint adventurers» in the cause of medical progress.

This is important: high cholesterol can be an indicator of other issues in the body that can increase risk of heart disease, but cholesterol itself is not the cause.

It can be a direct cause of death but is also the most important single risk factor for disease in young children.

«The discovery of HDMP in humans means that for the first time we are seeing an important mechanism in the process which causes the disease.

«They can teach us about the underlying causes of disease and point to important drug targets.»

Knowing the sex of a fetus is important when the mother is a carrier of an X-chromosome gene that can cause a disease such as muscular dystrophy.

Tobacco, obesity, diabetes, high alcohol intake and a family history of pancreatic cancer are all recognised risk factors for the disease, but explain less than 40 % of cases and important causes of the increasing trends yet have to be identified.

Remarkably, the researchers also found that blocking this protein in mice protected them from the lethal effects of dengue virus infection, an important finding given that an effective vaccine against dengue has remained elusive, partly because there are four serotypes of the virus that cause disease.

Trypanosoma cruzi, the parasite that causes Chagas disease, is divided into six strains, each of which differs in where they are found and in how important they are in human infections..

This finding, reported in today's Proceedings of the National Academy of Sciences, is an important example of a disease caused by the interaction of two genes.

Moreover, this CRISPR technique may eventually be an important intervention in situations where parents want to have a genetically related child but have a homozygous condition — say both parents have two copies of a disease - causing mutation like that which causes sickle cell — which would result in all embryos being affected by the disorder.

Julian Isla, Executive Director of DSF - EU, stated: «One of the most important things for patients with genetic disorders and their families is to be able to give a name to the gene causing their disease.

It's well - known that these two molecules play an important role in causing the painful rashes that are characteristic of the disease, but Claire Q. Wang, a research associate in James Krueger's Laboratory of Investigative Dermatology, wanted to see if IL - 17 and TNF might also have something to do with the dark spots that psoriasis leaves behind.

Elegant, dainty, and deadly, it is the most common of all blood - sucking arthropods and the most important insect carrier of human disease, transmitting not only malaria but also yellow fever, dengue, West Nile virus, encephalitis, and the tiny worms that cause elephantiasis.

The purple tomatoes were also less susceptible to one of the most important postharvest diseases, grey mould caused by Botrytis cinerea.

«This is the first study to show the actual cell behaviors caused by mutations in genes causally linked to polycystic kidney disease, an important new step in the path towards treatment,» said Dr. Robert L. Bacallao, associate professor of medicine at the IU School of Medicine in Indianapolis.

«Our findings have broad implications not only for malaria in pregnancy (125 million pregnancies at risk each year), but also for other globally important causes of adverse birth outcomes such as preeclampsia,» says Dr. Kain, who is also Science Director, Tropical Disease Unit at the Toronto General Hospital, UHN.

It's important to remember that we're not going after the primary cause of the disease, dystrophin deficiency.»

The amount of gluten could be a more important clue than breast - feeding or the timing of the introduction of gluten for continued research into the causes of celiac disease (gluten intolerance).

«This is important because the death of photoreceptor cells is known to cause retinal degenerative diseases in humans that lead to blindness.

«Given that abnormal synapse formation causes various neurodevelopmental diseases such as autism spectrum disorders and epilepsy, understanding activity - dependent mechanisms of initial synapse formation will be important for developing new therapeutic strategies for these conditions,» explained Dr. Kwon.

«Just like their matriarch, the Lacks family continues to have a significant impact on medical progress by providing access to an important scientific tool that researchers will use to study the cause and effect of many diseases with the goal of developing treatments,» said NIH Director Francis S. Collins, M.D., Ph.D..

«It's important to identify the cause of persistent halitosis, and differentiate that cause from relatively benign causes (e.g., gum disease) and the more morbid causes such as liver cirrhosis,» said Professor Kent Lloyd, director of the Mouse Biology Program at UC Davis.

«This is particularly important in cases of children and the parents of children who have cancer, helping them understand the root causes of this disease.»

Researchers led by Baylor College of Medicine have developed a new computational method to study the function of disease - causing genes, starting with an important new discovery about a gene associated with malaria — one of the biggest global health burdens.

The recent ability to peer into the brain of living individuals with a rare type of language dementia, primary progressive aphasia (PPA), provides important new insights into the beginning stages of this disease — which results in language loss — when it is caused by a buildup of a toxic protein found in Alzheimer's disease.

«In the future we hope to apply this strategy to target other disease - causing RNAs, which range from incurable cancers to important viral pathogens such as Zika and Ebola,» added Research Associate Sai Pradeep Velagapudi, the first author of the study and a member of the Disney lab.

Our results suggest that emerging diseases, spread from managed bees, may be an important cause of wild bee decline.»

It is important for all patients (and family members of patients) with macular degeneration to know that although the disease can injure the central vision of both eyes severely enough to render one «legally blind,» it is extremely uncommon to cause complete blindness in even a single eye.

This is important because it shows that we can find the genetic cause of diseases — even common diseases involving many mutations — if we sequence family genomes.

For instance, Cawthon points out, it's important to learn whether telomere shortening actually causes disease or is just a side - effect of something else.

Loss of, or diminished, retinal DHA leads to visual impairment and may play an important role in the development of blindness from retinitis pigmentosa and other retinal degenerative diseases, as well as age - related macular degeneration (AMD), the foremost cause of blindness in people older than 50 years.

In January the FDA approved Kalydeco, the first drug that repairs one of the most important of those flawed proteins, correcting a root cause of the disease.

But it's extremely important for understanding fatal diseases in humans, especially those caused by ageing,» said Professor David Gems (UCL Institute of Healthy Ageing), who led the team of researchers.

The process of figuring out which of these genetic differences lie on each chromosome is called haplotyping, and it's an important step toward identifying which version of a gene may cause disease.

Nevertheless, light is gradually being shed on its role in the control of the overall functioning of the genome, in other words, it regulates important processes in our organism such as immune response and that is where it might be possible to find the causes of auto - immune diseases such as celiac disease.

«While these findings require further study into the mechanism that causes shingles patients to have an increased risk of heart attack and stroke, it is important that physicians treating these patients make them aware of their increased risk,» said Sung - Han Kim, MD, PhD, a physician in the department of infectious diseases at Asan Medical Center in Seoul and one of the study authors.

«These enhancers can harbour disease - causing mutations which would be missed in traditional studies of genes, but which are suspected of playing an important role in inherited neurodevelopmental and neuropsychiatric disorders.

Our finding of sinusitis, bronchial hyperreactivity, and bronchial responsiveness in firefighters with World Trade Center cough is important but not surprising.17 - 20 An unexpected finding was that 87 percent of such firefighters reported symptoms of gastroesophageal reflux disease; such symptoms are generally reported by less than 25 percent of patients with chronic cough.1, 21,22 Despite the strong associations between gastroesophageal reflux disease and chronic cough17 - 20 and between gastroesophageal reflux disease and asthma,23 - 25 it remains unclear whether gastroesophageal reflux disease causes either condition.26 The causative mechanism may be repeated aspiration of minute amounts of refluxed material; vagally mediated esophageal, tracheobronchial, or laryngobronchial cough reflexes; or neurally mediated bronchial inflammation.23, 24,26 Involvement of the posterior nasopharynx is common in patients with gastroesophageal reflux disease, 27 whereas bronchial hyperreactivity may not be present.25, 26 For these reasons, we classified gastroesophageal reflux disease as an upper - airway symptom (Figure 2).

As the single most important cause of serious lower respiratory tract disease in infants and young children in the United States and globally, RSV is of considerable public health importance and a high priority for vaccine development.

«Identifying druggable targets that participate during the pre-symptomatic stage of the disease is particularly important,» Nishina says, «to enable development of therapies that can prevent, delay onset or decrease the severity of RPE - associated diseases irrespective of the initial cause of the disease.»

New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.

Cardiovascular and lung vascular diseases are important causes of morbidity and mortality in the US.

After observing important similarities between planarians and their disease - causing cousins, Newmark and former postdoctoral fellow Jim Collins (now a professor at UT Southwestern) took the radical step of applying their knowledge of planarians to studying schistosome biology.

This is important because we know that the procedure is not perfect, generally transmitting disease mtDNA at low levels as is the case here, and we now know that tissue - specific expansion of mutated mtDNA during development can occur (Naue, 2015) and so could cause disease if levels are high enough.