Sentences with phrase «important cell signaling pathways»

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

Not exact matches

They found that these genetic differences were tied to several important developmental and cell signaling pathways.

«We also showed for the first time that AHR signaling in primary human orbital fibroblasts disrupts the pro-fibrotic Wnt / β - catenin pathway, which is important for scar cell formation,» noted Dr. Phipps.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

«In fact, the CDKN2A takes part in the p53 signalling pathway, one of the most important ones in the cell senescence regulation,» adds Lucía.

This signaling pathway was found to be important in embryonic bone development (Wan et al., 2013), and in osteoblasts (bone cells) regulation (Glass et al., 2005; Harada & Rodan, 2003).

Her goals are to continue working to understand how the dynamics of p53 and other signaling pathways important in cancer control cell fate decisions.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

Dr. Aldred's lab will evaluate a new therapeutic approach known as nonsense readthrough, testing two drugs that may be able to correct genetic defects in an important cell - signaling pathway.

In CLL and other B - cell malignancies researchers have previously observed that deregulation of the NF kappa B (NF - kB) signalling pathway appears to be particularly important.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

These data support the hypothesis that ER - α plays an important role in the hypoxic CSC response in ER - α — positive cells and that signaling through this pathway is responsible, at least in part, for the increase in CSC.

The mutation impacts an important signaling pathway known as Wnt, that contributes to the function of many cell types.»

And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142 in human breast cancer cells and BCSCs.

Because miR - 142 is upregulated in the BCSCs and stimulates the canonical WNT signaling pathway that is an important regulator of the stem cell properties in mammary tissues, we tested the ability of miR - 142 to regulate the organoid formation of BCSCs.

There was no significant enrichment of genes in any functional category; however, GO annotations revealed 34 DEGs involved in biological processes important to the establishment of pregnancy, such as «regulation of apoptosis,» «vasculature development,» «neurogenesis,» «positive regulation of cell differentiation,» «Wnt receptor signaling pathway,» and «gland development.»

This pathway is one of the most important signalling mechanism in the body for protein synthesis and cell growth.

ROS are important signaling molecules for a number of different cell signaling pathways, particularly those associated with stress - response, and we are stress - response machines.

While some amount of omega - 6 s are important for membrane structure and cell signalling pathways (Institute of Medicine 2005), consuming too much can interfere with neurological development through inhibition of omega - 3 PUFA metabolism and availability (Novak et al. 2008).