For example, CRAC channels in T cells have been clinically validated
as important drug targets through human mutations and the use of calcineurin inhibitors that act downstream from CRAC channels.
«They can teach us about the underlying causes of disease and point to
important drug targets.»
This makes the serotonin receptor
an important drug target.
«The results of the study have important implications for the treatment of pain, and suggests that microglia may be
an important drug target to improve opioid pain relief in women,» said Dr. Anne Murphy, co-author on the study and associate professor in the Neuroscience Institute at Georgia State.
«No one has really figured out how to exploit
these important drug targets.
Hsp90 is
an important drug target for cancer and other diseases.
Both angiotensin II receptors are
important drug targets, since the blockade of AT1R has anti-hypertensive effects, while the modulation of AT2R could be useful for cardioprotection, neuropathic pain relief and the treatment of several other conditions.