Sentences with phrase «important gene in human»

The hypocretin receptor 2 gene could be the single most important gene in human narcolepsy, says Michael Aldrich, a neurologist and director of the University of Michigan's Sleep Disorders Center.

Not exact matches

«This highlights how important introgression events [the movement of genes across species] may have been in the evolution of the innate immunity system in humans.»

In the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not caused by any single genIn the intervening years, we have come to realize that many of the most interesting and important phenomena in human biology are not caused by any single genin human biology are not caused by any single gene.

Ironically, because of its pivotal role in coordinating a range of cancer - fighting mechanisms in the human body, it is also one of the most important cancer - causing genes when mutated.

In a new take on an old polemic, Ridley acts as mediator between biological and cultural determinists, arguing that genes and the environment play equally important roles in shaping human destinIn a new take on an old polemic, Ridley acts as mediator between biological and cultural determinists, arguing that genes and the environment play equally important roles in shaping human destinin shaping human destiny.

Since the publication of the human genome sequence in 2001, scientists have found that the so - called junk DNA that lies between genes actually carries out many important functions.

These are not genes but must have an important role because evolution has left them virtually unchanged in both humans and mice since our evolutionary paths parted about 75 million years ago.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

Since mice share 90 percent of our genes they play an important role in understanding human genetics.

Joint lead author Professor Manfred Kayser from Erasmus MC said: «Besides substantially increasing our understanding of human pigmentation genetics in general, finding these new hair colour genes is also important for further increasing the accuracy of hair colour prediction from DNA traces in future forensic applications, which can help to find unknown perpetrators of crime.»

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

«They help us to understand how the FOXP2 gene might have been important in the evolution of the human brain and direct us towards neural mechanisms that play a role in speech and language acquisition.»

Such genes play an important role in mate selection — not just in bats, but also in mice and possibly even humans.

For instance, genes that were deleterious only in human - Neanderthal hybrids might have existed, and sexual selection or other forms of selection against hybrids could have been very important processes during human - Neanderthal hybridization.

«This is by far the largest twin study of gene expression ever published, enabling us to make a roadmap of genes versus environment,» Sullivan says, adding that the study measured relationships with disease more precisely than had been previously possible, and uncovered important connections to recent human evolution and genetic influence in disease.

In 2013, CRISPR passed two important tests: It works in human cells, and it can target several genes at oncIn 2013, CRISPR passed two important tests: It works in human cells, and it can target several genes at oncin human cells, and it can target several genes at once.

Those tests will answer basic questions about changes in cells and genes; they are not the elaborate, years - long studies exposing lab animals or examining humans that can answer most important health questions.

This type of yeast shares many important genes with us and also has one of the two known condensin complexes in humans.

This phenomenon could result in breakage in the human genome, and when a breakage impacts important genes, such as tumor suppressors, it could lead to cancer development.

Sabeti's work is the latest to identify genes that were important in the evolution of humans, and our subsequent history.

How important was a single gene in the evolution of human language?

«MHC genes are an important line of defence in the immune system in vertebrates, including humans.

Indeed, a close look at the chimp genome reveals an important lesson in how genes and evolution work, and it suggests that chimps and humans are a lot more similar than even a neurobiologist might think.

In the study, the scientists used a type of mouse, called CVN - AD, that they had created several years ago by swapping out a handful of important genes to make the animal's immune system more similar to a human's.

It is important to keep in mind that these findings likely represent only a small fraction of the genes influencing the size and shape of the human face.

This approach has contributed to the successful mapping of genes involved in numerous human diseases such as Huntington's disease and cystic fibrosis, an important first step in understanding these conditions.

The study is «important as a proof - of - principle,» adds human geneticist Daniel MacArthur of the Broad Institute in Cambridge, Massachusetts, who himself is on the hunt for rare genes that protect against disease and wrote a commentary accompanying the new paper.

Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.

Thirty years ago, geneticist Mary - Claire King and biochemist Allan Wilson proposed that changes in how genes are regulated, rather than in the proteins they code for, could explain important differences between chimps and humans (Science, 11 April 1975, p. 107).

The finding that an important brain gene has continued to evolve adaptively in anatomically modern humans suggests the ongoing evolutionary plasticity of the human brain.

Some of the genes may be important in understanding the genetics behind disease as well as the evolution of the human brain.

The FOXO gene is important for longevity in a wide variety of species, including yeast, flies, worms and humans, so the team say the findings may have broad implications.

Studying zebrafish is a vitally important way to discover what role genes play in human health and disease.

Although mutations had been identified in other genes important for the recycling of bile acids, this is the first report in humans of disease - associated defects in this gene, called Organic Solute Transporter - beta (SLC51B).

Interestingly, runx1 is also one of the most frequently mutated genes in human leukemias, supporting that runx1 plays an important role in the adult.

This immune system gene is also found in humans and other animals, and is thought to be the most important gene for inherited immunity.

The results may indicate which genes are important for survival in the Huntington's and Parkinson's disease processes in humans.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

We first focused on SRGAP2 and its human - specific paralogs because we previously reported that this gene plays important roles during neocortical development, in particular regulating neuronal migration and dendritic branching (Guerrier et al., 2009).

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writIn the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

Gene and cell therapies have made important medical advances over the past three decade, developing technologies and testing novel therapies in multiple human clinical trials of many diseases.

On Wednesday we were saddened learned that double Nobel laureate Fred Sanger had died, so it was fitting that yesterday also saw the announcement of an important scientific advance that owes everything to the molecular biology revolution he helped to launch — one that may improve the lives of many thousands of people with Hemophilia A.... Continue reading Successful gene therapy for hemophilia A in dogs — humans next!

The presence of several mutations in four important genes for the brain's synapses can be associated to Obsessive Compulsive Disorder in humans.

The new knowledge is important for our understanding of how mutations in human genes give rise to diseases.

Such long - term expression is important for gene therapy studies in humans.

In addition, the mutations in ARID1A provide an important new link between genetic and epigenetic (alterations to the environment of genes) mechanisms in human canceIn addition, the mutations in ARID1A provide an important new link between genetic and epigenetic (alterations to the environment of genes) mechanisms in human cancein ARID1A provide an important new link between genetic and epigenetic (alterations to the environment of genes) mechanisms in human cancein human cancer.

«We believe that this finding has important clinical relevance because we can potentially prevent or decelerate the progression of colorectal cancer in humans, especially in those who have mutations in the AIM2 gene, by simply giving them «good» microbiota.»

The organism is widely studied because many of the genes that control the yeast's function are also important in humans.

The microbiome has become an important consideration, and particularly, the gut, which houses at least 10 times as many human cells as there are in our bodies, and 150 times as many genes as are in our genome.

Genetic analysis of dogs that are a cross between pointers and Dalmatians revealed that gene to be SLC2A9, a gene that recently has been reported to be important in regulating uric acid levels in humans.