Sentences with phrase «important gene variants»

Not exact matches

«In 2010, we unsuccessfully tried testing genes involved in detoxification and concluded that variants in detoxification genes and pathways are less important than previously thought,» says the center's director, Sine Skovbjerg Jakobsen.

Two important genes known to be close to the chromosome 15 variant region are involved with DNA repair and replication and with intracellular signaling.

Genetic factors can contribute to the degree of longevity in at least two important ways: An individual may inherit certain genetic variations that predispose him or her to disease that decreases longevity; other gene variants may confer disease resistance, thereby increasing it.

However, the researchers found that a variation of ECR47 associated with ADHD disrupted ECR47's ability to bind an important neurodevelopmental transcription factor, YY1 — an indication that the risk variant interferes with gene transcription.

«At this stage, it is unclear how many people with ALS have the UBQLN4 gene variant, and this will be important to determine,» says Ma, the senior author on the study who is Ann Marie and Francis Klocke, MD Research Scholar at the Manne Research Institute and Assistant Professor at Northwestern University Feinberg School of Medicine.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Specifically, the epsilon 4 variant of the APOE gene appears to represent an important risk factor for later - onset dementia, although the mechanism is unclear.

Genetic screening later revealed that 24 percent of centenarians from Ashkenazi Jewish populations carry a variant in the CETP gene — an enzyme important for cholesterol metabolism — that reduces the level of the protein CETP in the blood and is linked to a lower prevalence of hypertension, cardiovascular disease and memory loss.

The FRO2 gene is common to all plants, so boosting its expression in food crops or finding variants that thrive in poor soils could be important for increasing crop yields in the face of population growth and global warming's threats to arable land.

It found that people with the variant of the GRM3 gene, thought to be important in brain signalling, were at increased risk of developing bipolar disorder, schizophrenia and alcohol dependence.

«Identifying gene variants that are general risk factors for neurological and psychiatric disease is important, but understanding exactly which cell types in the developing brain are compromised and what the consequences are is still extremely challenging,» Pollen added.

«This research is an important addition to the field because previous studies looking at CYP gene variants and their effects on risks of repeat heart attacks, bleeding and death have included predominantly Caucasian patients of European ancestry,» Cresci noted.

The researchers, chiefly from the Broad Institute, Harvard Medical School and Boston Children's Hospital, found that a person's risk of schizophrenia is dramatically increased if they inherit variants of a gene important to «synaptic pruning» — the healthy reduction during adolescence of brain cell connections that are no longer needed.

The variant surface antigens expressed on Plasmodium falciparum - infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every parasite genome.

It is important to note whether a test interrogates a set of common variants, or sequences entire genes (and identifies both common and rare variants).

As a result, the misidentification of genetic variants associated to the Neolithic spread and the effect of post-Neolithic expansions in the genetic make - up of Europe could have introduced important biases in the estimations of the Neolithic component of the European gene pool producing misleading conclusions [22].

It is important to note that even if this gene variant did become dominant, it would not be sufficient to prevent alcohol dependence alone.

Evidence for multiple copies of the salivary amylase gene in high starch eating Asians, and a gene variant that is important for breaking down fats in plant foods in Europeans and Middle Easterners may reflect an adaption to agriculture (Hancock et al, 2010).