Sentences with phrase «important of these alterations»

If you were a fan of the series on PC, then the most important of these alterations will be the touchscreen controls.

Not exact matches

Amazon is by far the most influential player when it comes to forces driving the most impactful and important alterations made in the arena of commerce and its digital transformation.

The grace His Divine sacrifice brought to each one of us is truly the most important interruption of the narrative, a change to the story - line, a alteration of the eternal path we would have had to take.

This is an important qualification for a number of reasons, most obviously that if one of the justifications for engagement in interreligious polemics is that it is heuristically valuable (as are its analogues in other dimensions of the intellectual life), then obviously revision, alteration, and abandonment of passionately held religious views must be a possibility.

«In terms of the transfer market, we've made important alterations,» Malago said.

In their conclusion, the authors state that it is important for conservationists to see climate change not as one of numerous independent variables acting on species survival in mountain landscapes, but as an exacerbating force over the many direct human alterations to these areas.

Or is minimizing alterations to the global environment introduced by human activity — rising levels of CO2 from fossil - fuel burning, widespread extinction, dams that impound water — more important to our success?

Gross says that the most important processes affecting day length are changes in the weather, especially unusual variations in the strength and direction of the winds, which bring on alterations in the global circulation of the atmosphere and ocean.

«Therefore, it is important to consider this receptor subtype as potential target for the treatment of psychiatric illnesses characterized by alterations in personal relevance attribution.»

«Some of these genes were either increased or decreased in the area of the tumour, no matter the type of breast cancer, and this is important because within the patterns we identified were predictable alterations.

Douglas Thomas, associate professor of medicinal chemistry and pharmacognosy at UIC, and co-workers discovered that nitric oxide plays an important role in epigenetics — heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

«It is important to begin mechanistic studies of these declines,» the team concludes in a paper presenting the finding published in today's Science, «with habitat alteration, climate change and agricultural chemical usage being potential key drivers of observed shifts.»

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

«This study is important,» said Libero who is now a post-doctoral scholar at the University of California - Davis MIND Institute (Medical Investigation of Neurodevelopmental Disorders), «because we found that different combinations of alterations in the brain could lead to the same or different levels of symptom severity.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

Epigenetics is being recognized as an increasingly important area of research that involves an understanding of the molecular mechanisms that influence the phenotypic outcome of the genome without alteration of the DNA sequence.

In a collaborative study, researchers from Chinese Academy of Medical Sciences and Peking Union Medical College, BGI, Shantou University Medical College and other institutions identified important alterations of tumor - associated genes and tumorigenic pathways in esophageal squamous cell cancer (ESCC), one of the leading cause of cancer death worldwide.

In a relatively short period since its foundation in 2002, the CRG has generated important scientific insights in our understanding of the organization, deployment and evolution of genetic information, the internal workings of cells, their differentiation and reprogramming, their collective organization to form tissues and their alterations in disease, including cancer.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

Conclusions: The identification of gene expression alterations as a function of hypoxia and recovery from hypoxia is important to understand the molecular mechanisms underlying retinal dysfunction associated with a variety of diseases.

«It's an important point, because a high level of concern exists about making permanent alterations to a patient's germ line that would be perpetuated to his descendants.

Lead author, Dr Amanda Swain, from the Section of Gene Function and Regulation at the ICR, said: «The discovery that BRCA2 alterations play the same role in the development of hereditary prostate cancer as they do in breast cancer is an important step.

Serotonin (5 - HT) 2C receptors play an important role in the modulation of monoaminergic transmission, mood, motor behaviour, appetite and endocrine secretion, and alterations in their functional

In addition, the mutations in ARID1A provide an important new link between genetic and epigenetic (alterations to the environment of genes) mechanisms in human cancer.

«This remains to be tested, but the findings suggest that alterations in methylation are an important early step in the development of leukemia,» Mullighan said.

Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.

This loss of binding is often accompanied by a loss of ability to express (Barnwell et al. 1983; Handunetti et al. 1987; Gilks et al. 1990)-- or a major alteration in the level of expression of (David et al. 1983; Fandeur et al. 1995)-- the highly variable and clonally variant switching parasite antigens on the surface of the red cell known to be important for the maintenance of long - term chronic infections (Brown and Brown 1965).

In terms of core gameplay though The Millennium Girl has changed little and arguably its most important alteration is that it now has three different difficultly levels available from the start.

These alterations combine to increase total downforce across the whole of the Cayman body, an important feature when blitzing the «Ring.

More clearly defining the populations most impacted by particular disorders is necessary to monitor alterations in incidence and seek constructive and effective mechanisms to reduce the burden of disease, thereby providing important knowledge for breeders, owners, researchers, and practitioners.

I am a practising medical practioner and acid - base balance is a very important part of the homeostasis of the organism, and small alterations of this have some profound effects.

It is very important to stake a claim as soon as possible to have a better chance of examining the original area of the incident with no alterations.

«To make the most of your insurance dollars, it is very important that you let your insurance agent or company representative know about alterations to your home and other major events in your life,» says Jeanne M. Salvatore, senior vice president and consumer spokesperson for the I.I.I. «A great way to start the new year off on a firm financial footing is to discuss your current insurance needs with your agent, broker or company representative to make sure that it is up - to - date.»

In early childhood development, attachment is so important that a lack of connection to a secure attachment figure (most likely the mother, father, or other major caregiver) who was reliable and available results in physical alterations to the anatomy and chemistry of the brain, such as reduced brain activity and less developed cortexes.

It has been reported that maternal PPD is a predictor of paternal one since the first is higher during the three months postpartum.8 Based on the existing knowledge of maternal PPD, literature suggests that also paternal PPD could be related with hormonal changes regarding alteration of testosterone, estrogen, vasopressin, prolactin and cortisol levels.10 In addition to mood disturbances, high parenting distress levels could also be considered a important factor compromising the parenting competence and the daily child care.17 Parenting stress is a construct related to the parent role and influenced by expectations and perceptions of child characteristics, parent characteristics and parental - infant interaction quality.

The first month after partum represents a critical phase of parents life and it could be considered a developmental crisis characterized by anxiety, stress and mood alterations that could have important repercussions on the child psycho - physical development.