Sentences with phrase «important predisposing factor»
High IgE levels are a key clinical measure of an aggravated immune sensitivity to certain particles in the environment — the basis of atopy (allergies) and an important predisposing factor to the development of asthma.
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Genetic factors can contribute to the degree of longevity in at least two important ways: An individual may inherit certain genetic variations that predispose him or her to disease that decreases longevity; other gene variants may confer disease resistance, thereby increasing it.
Interestingly, we have earlier reported for the predominance of the inflammatory milieu of the pancreas [17, 18], adipose [35] and bone marrow in WNIN / Gr - Ob rats [14] and probably this may be an important confounding factor to predispose WNIN / Gr - Ob rats toward development of pancreatitis, as compared to their age - matched parental control rats [17].
Risk for negative outcomes may be modified by both genetic and environmental factors, with the quality and availability of social supports among the most important environmental factors in promoting resiliency, even in the presence of a genotype expected to predispose to psychiatric disorder.