Sentences with phrase «important signaling pathways»

In addition, more than 600 genes are either receptors or associate closely with receptors, providing a thorough analysis of important signaling pathways.

By probing the biology of B. anthracis lethal toxin we have identified MEK1 / 2 - ERK 1/2 and MKK3 / 6 - p 38 as important signaling pathways in the production of IL - 22 in ILC3s.

The elucidation of the structure and function of this complex serves as a crucial step in the ongoing effort to identify clinically important drugs with which this important signaling pathway can be targeted.

The mutation impacts an important signaling pathway known as Wnt, that contributes to the function of many cell types.»

Eating too much protein can also activate your body's most important signaling pathway — mTOR, or the mammalian target of rapamycin — and boost your risk of cancer.

Not exact matches

«Certainly at the molecular level, research on signal pathways and chemistry are important,» Jock says.

That finding confirms the important role these signaling pathways play in dental development.

They found that these genetic differences were tied to several important developmental and cell signaling pathways.

This signaling pathway is dependent on a molecule that plays an important role in bacterial stress response: Guanosine tetraphosphate.

Through many painstaking experiments, she zeroed in on a signaling pathway called Wnt, known to be important in mouse lung development.

«We also showed for the first time that AHR signaling in primary human orbital fibroblasts disrupts the pro-fibrotic Wnt / β - catenin pathway, which is important for scar cell formation,» noted Dr. Phipps.

One of the top defective pathways in the iPSCs was the Wnt signaling pathway, which plays an important role in neuronal development.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

Gamma secretase inhibitors tend to produce adverse effects by interacting with Notch, an important pathway for cellular signaling.

In addition to NANCI, the team identified another lncRNA, which they named LL34, that regulates retinoic acid signaling, another important pathway for early lung development.

Their findings may turn out to be important when it comes to research into cerebral cancer, since it is known that components of the Hippo signaling pathway, such as neurofibromin 2, are involved in the generation of brain tumors.

«And this model not only shows us the most important factors that contribute to the onset of anorexia, it's also helping us to identify signaling pathways in the brain that ultimately drive this potentially fatal eating disorder.»

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

The NUCKS protein is a key player in insulin signalling, an important biochemical pathway that is needed to respond to insulin hormones, which promote the uptake of glucose to regulate blood glucose levels.

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

«In fact, the CDKN2A takes part in the p53 signalling pathway, one of the most important ones in the cell senescence regulation,» adds Lucía.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

«We discovered that male zebrafish have a very important set of structures on their pectoral fins that they use for breeding and that these structures secrete a potent molecular inhibitor of a key signaling pathway to aid their cycles of regular replacement,» explains senior author Kenneth Poss of Duke University Medical Center.

This is important because many different pro-fibrotic signaling pathways converge on the genome to affect their fibrotic response.»

While our studies provide important insight into the molecular pathophysiology of the mutant ACVR1 receptor on the BMP signaling pathway in FOP, interpretations of these data are limited to those allowed by the experimental systems used.

Toll / interleukin -1 receptor (TIR) domain - containing proteins play important roles in defense against pathogens in both animals and plants, connecting the immunity signaling pathways via a chain of specific protein - protein interactions.

What's next: Important follow - on studies include using these initial discoveries to design targeted efforts for understanding the specific signaling pathways under EGFR transactivation.

This signaling pathway was found to be important in embryonic bone development (Wan et al., 2013), and in osteoblasts (bone cells) regulation (Glass et al., 2005; Harada & Rodan, 2003).

Furthermore, in this signaling pathway the Met gene plays an important role in the development of Klatskin carcinoma.

Her goals are to continue working to understand how the dynamics of p53 and other signaling pathways important in cancer control cell fate decisions.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

Dr. Aldred's lab will evaluate a new therapeutic approach known as nonsense readthrough, testing two drugs that may be able to correct genetic defects in an important cell - signaling pathway.

In CLL and other B - cell malignancies researchers have previously observed that deregulation of the NF kappa B (NF - kB) signalling pathway appears to be particularly important.

On the next slide I show you basically the key domain that's involved in this signaling interaction, so when the insulin receptor is phosphorylated, in order to recruit adaptors such as IRS - 1, it uses an important domain called the PTP domain, or phosphotyrosine containing peptides that can actually mediate this interaction, and lead to the interaction of these various molecules within the pathway.

This is a very important lipid, that actually is involved in signaling, to many other kinases, and the key kinase that through this pathway gets activated is Akt; and Akt is a very important kinase that regulates many other factors.

Basically, there are a number of key pathways that regulate metabolism, but leptin and insulin signaling are really important.

Thus, our data are complementary and show that MAPK is a central signaling pathway in IL -23-mediated IL - 22 production in ILC3s, suggesting that this is an evolutionarily conserved and important pathway.

The DISC1 - mutant mini-brains also show increased signaling in the WNT pathway, a pathway known to be important for patterning organs and one that is disrupted in bipolar disorder.

The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation.

Important advances have included the discovery of the first evidence that the odour response is governed by neurons, of the intracellular signalling pathways between odorant receptors and sensory neurons, and of specific neurons, receptors and neurotransmitters involved in behaviour adaption following experience.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

Because both notum and the Wnt signaling pathway are so evolutionarily ancient, their interaction in planarians may indicate a relationship that is important in other animals as well.

These data support the hypothesis that ER - α plays an important role in the hypoxic CSC response in ER - α — positive cells and that signaling through this pathway is responsible, at least in part, for the increase in CSC.

The striatum (red) plays an important role in the learning of new tasks by a «use it or lose it» process of reinforcement of nerve signalling pathways.

These results highlight important pathways involved in the pathogenesis of fibrosis, including WNT signaling, extracellular matrix modulation, and inflammation.

And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142 in human breast cancer cells and BCSCs.

Our finding that Gasp constitutively associated with Grb2 is quite intriguing and provides some possible links to hypothesize its function in positive selection, because Grb2 is an important adaptor for Sos in the TCR - mediated signal transduction pathway.

Because miR - 142 is upregulated in the BCSCs and stimulates the canonical WNT signaling pathway that is an important regulator of the stem cell properties in mammary tissues, we tested the ability of miR - 142 to regulate the organoid formation of BCSCs.

There was no significant enrichment of genes in any functional category; however, GO annotations revealed 34 DEGs involved in biological processes important to the establishment of pregnancy, such as «regulation of apoptosis,» «vasculature development,» «neurogenesis,» «positive regulation of cell differentiation,» «Wnt receptor signaling pathway,» and «gland development.»