Polyploid cells, which carry additional copies of
important tumor suppressor genes, are better protected and more resistant to cancer formation because they have these extra copies of the genome,» said Dr. Zhu, who is also an Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern.
Not exact matches
This phenomenon could result in breakage in the human genome, and when a breakage impacts
important genes, such as
tumor suppressors, it could lead to cancer development.
His team identified a factor that may be
important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the
tumor suppressor gene p53 is mutated.
Cold Spring Harbor, NY — The
gene called PTEN is one of the most
important of the body's natural
tumor suppressors.