Sentences with phrase «imprinted gene in humans»

In 1993, three researchers spanning the globe — Anthony Reeve at the University of Otago in Dunedin, New Zealand, Rolf Ohlsson at the Karolinska Institute in Stockholm, and Andrew Feinberg at Johns Hopkins University in Baltimore, Maryland — independently discovered the first imprinted gene in humans.

Not exact matches

Until now, roughly 150 imprinted genes have been found in mice and about half that number in humans.

As the evolutionist David Haig of Harvard first suggested in 1989, these human imprinted genes are a case of intersexual competition, fruit fly sperm wars redux.

So what are these imprinted genes doing in a human couple pondering which appetizers to serve at their golden wedding anniversary?

Imprinting means that in some places along the human genome — about 100 genes in all — the way DNA behaves depends on which parent passes it to the offspring.

And in humans, too, when the imprinting process goes awry (as when a gene that is usually turned on is switched off, or the reverse), the consequences can be devastating.

She also suggested her company had already produced cloned human embryos and developed a method to screen for imprinting defects in 10 human genes.

Identifying a full list of imprinted genes for humans and model organisms will give scientists a springboard to characterize the mechanisms and functions of imprinting, says Ian Morison of the University of Otago in Dunedin, New Zealand.

ONE - PARENT SAMPLE SET PARENTAL GUIDANCE RULES: Maternally methylated (red dots) and paternally methylated (blue dots) regions across the human autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are exprehuman autosomal chromosomes, based on studies of uniparental disomy samplesGENOME RES, 24:554 - 69, 2014 RESEARCHERS Kazuhiko Nakabayashi, Division Chief, Department of Maternal - Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan; David Monk, Principal Investigator, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research ORGANISM Human METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expreHuman METHODS Bisulfite - seq; bisulfite - chip Methylation is typically associated with the silencing of the nonexpressed allele, making it a convenient marker for imprinted genes, though it's possible for patterns of differential methylation to exist in tissues where both alleles are expressed.

Imprinted genes have one parental allele silenced epigenetically, and they play critical roles in human development (Jirtle and Weidman 2007).