Sentences with phrase «imprinted genes in the mouse»

Modifying a histone called H3K27 shuts down the activity of some imprinted genes in mice, Howard Hughes Medical Institute (HHMI) Investigator Yi Zhang and colleagues report July 19 in the journal Nature.

This study led to the discovery of 18 new imprinted genes, validated some known genes and resolved the disputed status of some others to provide a gold standard list of 93 imprinted genes in mouse.

FINDINGS The researchers identified 32 known imprinted genes, but no new ones, implying that the list of imprinted genes in the mouse — at least in embryonic fibroblasts — is nearly complete, says Morison, who was not involved in the study (Nucleic Acids Res, 42:1772 - 83, 2014).

Not exact matches

Until now, roughly 150 imprinted genes have been found in mice and about half that number in humans.

One leap forward came in 1991, when the first imprinted genes were reported in mice, says Marisa Bartolomei, one of the co-discoverers, who was a postdoctoral fellow at the time and is now at the University of Pennsylvania.

There is also the fact that Kono and Kawahara had to manipulate two genes to create their bi-maternal mice — so the differences in lifespan might be due to this genetic manipulation, rather than the absence of paternally imprinted genes.

«This is the first study to offer an unbiased profile of novel imprinted genes in a mammal other than mice,» said lead author Xu Wang, a postdoctoral associate in the laboratory of Andrew Clark, professor of molecular biology and genetics and the study's senior author.

At the same time, as in mice, paternally imprinted genes heavily regulate placental development in these animals.

So they bred mutant mice in which the imprinting - control regions for these genes were deleted, allowing them to be expressed the way they would be in the male genome.

TEST CASE RESEARCHER Piroska Szabó, Associate Professor, Center for Epigenetics, Van Andel Research Institute ORGANISM Mouse METHOD RNA - seq In 2014, Szabó and colleagues reported how they'd used mouse embryonic fibroblasts to test whether the relatively new method of RNA sequencing could reveal known and novel imprinted gMouse METHOD RNA - seq In 2014, Szabó and colleagues reported how they'd used mouse embryonic fibroblasts to test whether the relatively new method of RNA sequencing could reveal known and novel imprinted gmouse embryonic fibroblasts to test whether the relatively new method of RNA sequencing could reveal known and novel imprinted genes.

The variation of the retrotransposons Erv and Iap mRNA amounts and of one of the three imprinted genes analyzed (paternal expressed Zrsr1) suggests that some epigenetic alterations are produced by IVC in the testes of adult mice.