Sentences with phrase «improve animal models»

FOA encourages research grant applications from institutions / organizations that propose to develop, characterize or improve animal models for human disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes.

Major recent advances in understanding GVHD's underlying biology, improved animal models, better targeting of interventions, and more systematic clinical trials are finally moving beyond «accumulated sketchy information,» Pavletic says.

The research should have several positive real - world outcomes, including improving the animal models that scientists utilize for metastatic prostate cancer experiments.

Improved animal models of Parkinsonism are essential to advance our understanding of disease pathophysiology and for eventual testing of potential therapeutics.

Not exact matches

To evaluate a model system of inspection, operating under HACCP principles, a third inspection system known as HACCP - based Inspection Models Project (HIMP) was initiated in 1998 to evaluate the ability of the HIMP model to improve the safety of processed animals and poultry.

Headquartered in La Mirada, Calif., its specialized market segments encompass six distinct distribution business units: FoodTech, Nutraceuticals, Animal Wellness, Advanced Materials, Coatings and Building Materials and Care Elements For more than 50 years, HORN's entrepreneurial approach to customer service embraces challenge and opens opportunities to reinvent and improve on traditional business models.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

The laboratories also collaborated to successfully prove that reversing a protein deficiency through gene therapy is effective in improving and stabilizing SMA in a large animal model.

«Magnetically applied MicroRNAs could one day help relieve constipation: Micro metal beads and magnets help deliver a biologic where it's needed to improve constipation or rectoanal incontinence in animal models of the disorders..»

This finding is in accordance with earlier animal model studies, which have shown that physical activity increases the amount of growth factors in the brain and improves synaptic plasticity.

Prior evidence in animal models demonstrated that exenatide improved motor performance.

Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

Our studies have improved our understanding of the basic biology underlying MMA, created a novel animal model for testing interventions and, now, led us to the promise of a new therapy.»

This study shows that inhibiting PRMT5 can significantly improve survival in an animal model of GBM.

Their series of experiments showed that a single application of concentrated, mature B cells accelerated wound healing and improved the quality of tissue repair in both animal models.

A previous study from the MGH team found that injecting B cells into cardiac tissue damaged by a heart attack improved structural and functional recovery in an animal model.

«Mature B lymphocytes accelerate the healing of diabetic ulcers, other skin injuries: Direct application of immune cells speeds and improves healing of acute and chronic wounds in animal models.»

«In animal models,» Lee explains, «the question we want to ask is, can we reduce the pathology and also rescue cell loss to improve the behavioral deficits?»

While more data are needed to improve the model, and it is unclear if it can be extrapolated to animals of much larger body mass, the researchers hope that it might help predict features of non-avian dinosaur locomotion using data from fossils and footprints.

In the end, three companies formed to try to exploit CRISPR to create novel medicines, while Broad and two other companies licensed the technology to partners that hoped to engineer everything from improved crops and livestock to better animal models and industrial chemicals.

«In previous studies we showed that it is possible to improve long - term memory by regulating the course of the PKR protein and the eIF2 in models in young and healthy animals.

Efforts to improve patient outcomes, particularly for those with high - risk Group 4 medulloblastoma, have been hampered by the lack of accurate animal models.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

Analogous behavioral assays are needed across animal models and human patients to improve translational research.

Sensitive and analogous behavioral assays in animal models and humans are needed to improve the translational predictability of therapeutic strategies.

UNISI is WP Leader of WP13 TNA7 «Immunocorrelates and Systems Biology»; and partner of WP5 JRA4 «Immuno - correlates and Systems Biology», WP3 JRA1: Improved optimisation and harmonisation of cross-vector screening, WP7, TNA 1 «Cross-platform screening and optimisation service» and WP6 «JRA5: Animal models»

I think only the future will be able to show whether we can use these strategies really to improve clinical deficits first in animal models, and then later on, of course, also in clinical trials.

Thus there is an urgent need for systematically studying, improving and assessing the suitability of different animal models for different diseases.

Research will aim to improve the predictive value of animal models for vaccine evaluation, provide consultancy on the selection of appropriate models, and develop innovative approaches to characterise in vivo antigen behaviour and host responses whilst reducing animal use.

Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.

In addition, the systems biology research will heavily support the activities to improve the predictability of animal models.

[31] Animal brain metastasis models have demonstrated significant tumor response and improved survival with this compound.

Injecting breast cancer with oxygen - filled microbubbles makes tumors three - times more sensitive to radiation therapy and improves survival in animal models of the disease.

Our work mainly involves research and clinical groups of Normandie developing programs in patients and animal models, to improve our understanding of the impact of cancer and its treatments on cognitive functions.

The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the disease.

An impressive patient account exemplified how novel therapies developed using animal models improve human health and saves lives.

LONDON (July 16, 2017)-- Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance.

Dr. Blaser is identifying the factors that promote successful engraftment of transplanted cells in animal models, which he will then attempt to translate into improved approaches for human patients.

Determining the mechanism for these sex - based differences in airway inflammation and the contribution of the microbiome in animal models would improve our ability to treat or prevent asthma and other autoimmune diseases in women.

Current work focuses on identifying novel Eph receptor - targeting agents (such as peptides and small molecules) as well as improving the existing ones in collaboration with medicinal chemists and structural biologists, and evaluating them in cell culture and in vivo animal models.

While many of treatments were able to shift biomarkers in human subjects as they did animal models, they did not improve or stabilize the cognitive performance and functional status of the patients.

Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.

Additionally, in animal models of AD exercise improves performance on memory tasks and reduces AD - like pathology (Stranahan et al., 2012; Intlekofer and Cotman, 2013).

Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent.

The lab is working to harness this mechanism to improve the clinical outcome in animal models of the many neurodegenerative disorders that have an inflammatory component, including ALS, Alzheimer's and Parkinson's diseases.

Working with animal models, researchers at Joslin Diabetes Center now have demonstrated the potential of giving a drug in combination with tPA that might improve stroke outcomes and increase the window of opportunity for the therapy.

Acetylcholinesterase inhibitors have been demonstrated to improve learning and memory in a number of animal models of cognitive dysfunction, as well as being a standard of treatment in patients exhibiting clinical signs of memory loss.

Improve, refine and when applicable develop more relevant new animal models of chronic pain — spontaneous (and evoked