Sentences with phrase «improve cell survival»

This phenomenon leads to difficulties in handling cells in applications such as passaging, cryopreservation and transfection, and the treatment with ROCK inhibitors has been found to effectively improve cell survival.

«These findings suggest that BES may thus be used as a strategy to improve cell survival and prevent cell apoptosis in stem cell - based transplantation therapies,» Fan explained.

Treating human apoE4 neurons with a structure corrector eliminated the signs of Alzheimer's disease, restored normal function to the cells, and improved cell survival.

When ketone bodies have been used in animals and cell cultures, they have demonstrated neuroprotective qualities such as improving cell survival and cognitive performance (1).

Not exact matches

April 16 Merck & Co's immunotherapy Keytruda plus chemotherapy significantly improved overall survival versus chemotherapy alone in newly - diagnosed patients with advanced non-small cell lung cancer in a highly - anticipated study that appears to cement the company's lead in the most lucrative oncology market.

Mutations that improve a cell's odds of survival are «selected for,» while non-adaptive cells are weeded out in the evolutionary lottery.

The researchers also affected mouse models with Mantle Cell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall surviCell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall survicell death and dramatically improve overall survival.

The work could help make marrow transplants more effective by improving the survival of transplanted cells.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

Drs. Prud «homme and Wang also found that GABA vastly improved the survival rate of pancreatic cells when they were being transplanted into mice.

While some previous studies found that maintenance lenalidomide after autologous hematopoietic stem cell transplant improved overall survival for newly diagnosed multiple myeloma patients, others showed no benefit to this approach.

GLP - 1 receptors are also found in the brain, and prior research has shown that activating them can boost the function of dopamine connections, act as an anti-inflammatory, improve energy production, and switch on cell survival signals.

The development of targeted therapies has significantly improved the survival of melanoma patients over the last decade; however, patients often relapse because many therapies do not kill all of the tumor cells, and the remaining cells adapt to treatment and become resistant.

Delivering a single injection of a scar - busting gene therapy to the spinal cord of rats following injury promotes the survival of nerve cells and improves hind limb function within weeks, according to a study published April 2 in The Journal of Neuroscience.

The five year disease - free and overall survival rates for patients with high - risk malignant germ cell tumours remains less than 50 %, and so accurate diagnosis and monitoring is crucial to improving outcomes for patients.

«Immunotherapy drug nearly eliminates severe acute graft - versus - host disease: Drug used to treat rheumatoid arthritis improves survival after hematopoietic stem cell transplant.»

He found that red ginseng extract improves the survival of human lung epithelial cells infected with influenza virus.

Kang found Korean red ginseng extract improved the survival of human lung epithelial cells against RSV infection and inhibited the virus from replicating, or multiplying, in the body.

Results showed that antibodies were able to bind to the cancer cells and recruited specific immune cells called natural killer cells, resulting in shrinkage of the tumor, significantly improving survival.

She also noted the targeting Msi in primary tumors significantly changed «the trajectory of progression by halting pancreatic cancer growth and improving survival,» inhibiting both cancer stem cells and other tumor cells.

Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS - variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation.

«Prostate cancer cells grow with malfunction of cholesterol control in cells: Shutting down this source at the root cause could improve cancer survival.»

Scientists from KU Leuven, Belgium, have now improved survival of these bone cells by preconditioning them to withstand the harmful environment before implantation.

«Better survival of implanted cells improves healing of bone fractures.»

The strategy of giving a higher proportion of plasma is based on the belief that maintaining the balance of coagulation factors carried in plasma would reduce the overall amount of bleeding, requiring lower amounts of red blood cells and improving survival.

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

Co-author Professor Richard Marais, director of the Cancer Research UK Manchester Institute at The University of Manchester, said: «Understanding the complex behaviour of melanoma cells is vital to improving survival.

Haruo Ohtani and colleagues at the Kitasato University School of Medicine in Japan publish a landmark study showing that the presence and location of CD8 + tumor - infiltrating lymphocytes (TILs) correlates with prognosis in colon cancers, specifically that the accumulation of CD8 + T cells within the tumor predicted improved patient survival, whereas accumulation of the same cells in the tumor periphery did not correlate with survival.

The earliest and one of the most striking came from observations that the presence of infiltrating T cells (called «tumor - infiltrating lymphocytes,» or TILs) in ovarian tumors is positively and strongly associated with improved survival of patients with ovarian cancer [1].

They want functional tests demonstrating that defects in your gene improve the growth, survival, proliferation, or metastatic potential of cells.

A later study by CRI scientists confirmed that patients with higher frequencies of infiltrating killer T cells had improved survival [2].

Relative to XpdTTD / KO hemizygote cells, UV survival was improved by the homozygous lethal Xpd † XPCS allele in XpdTTD / † XPCS compound heterozygous cells and to a lesser degree by the Xpd † XP allele (Figure 4A).

Thus, the improved UV survival observed in compound heterozygote cells (Figure 4A) and likely the rescue of TTD progeroid symptoms (Figure 3) were not due to normalisation of TFIIH levels, suggesting a qualitative rather than a quantitative effect on these phenotypes in vivo.

A randomized, phase II trial showed improved progression - free survival in small - cell lung cancer with maintenance sunitinib vs placebo following standard chemotherapy, according to results presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

DENVER — Elderly patients with stage III non-small cell lung cancer (NSCLC) showed improved overall survival (OS) when treated with chemoradiation (CRT) compared to definitive radiation (RT) alone.

Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord.

After seeing significantly improved long - term survival and integration of the transplanted cells, the next step was to see if the cells actually functioned.

Interestingly, BDNF improves pregnancy rates by increasing trophoblast cell growth and survival via its receptor NTRK2 expressed by the trophectoderm of blastocysts [37].

Despite its ability to target tumor cells and promote an immune response, T - VEC has not been shown to improve overall survival or have an effect on visceral metastases.

Importantly, when mice received lethal doses of host - type acute leukemia cells, administration of VPA did not impair GVL activity and resulted in significantly improved leukemia - free survival.

Now, a drug that activates CB2 receptors on immune cells has been shown to improve symptoms and survival in HD mice - with interesting implications for the immune system as a target for HD therapies.

High - Dose Chemotherapy Plus Transplant Not Recommended for DLBCL: The results of an Italian study report that treatment of high - risk diffuse large B - cell lymphoma (DLBCL) with abbreviated course of rituximab dose - dense chemotherapy plus high - dose cytarabine, mitoxantrone, and dexamethasone (R - MAD) plus carmustine, etoposide, cytarabine, and melphalan (BEAM) plus autologous stem cell transplantation compared with a full course of rituximab dose - dense chemotherapy did not improve overall survival.

Calcitonin gene - related peptide (CGRP) has been shown to improve survival of lung epithelial cells and reduce hyperoxic lung injury in rats.

In mice, which are mammals like humans, MSI - 1436 improved heart function, increased survival, reduced scarring and stimulated the proliferation of heart muscle cells.

The mice that received the therapy had 10 times higher islet cell mass, three times higher insulin levels and improved insulin sensitivity and islet cell survival compared to the untreated mice.

Lithium might also protect the brain from numerous damaging compounds by increasing bcl - 2, a protein that may improve the survival of brain cells even possibly from damage cause by a stroke.

Sorenmo KU, Krick E, Coughlin CM, Overley B, Gregor TP, et al. (2011) CD40 - Activated B Cell Cancer Vaccine Improves Second Clinical Remission and Survival in Privately Owned Dogs with Non-Hodgkin's Lymphoma.

If you know someone who is fighting the dreaded proliferation of abnormal cells (that's what cancer is) you should do careful research, starting with the knowledge that the average cost to treat a cancer patient was $ 670,000 in 2011 and survival rates had not improved.

Rituximab Improves Overall Survival in Patients Treated with CODOX - M / IVAC for Burkitt Lymphoma (BL) and B - Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B - Cell Lymphoma and BL (BCL - U): A Single Center Experience and Review of the Literature