The cryotherapy process reduces inflammation for pain relief and
improved mobility by decreasing the
cellular metabolism, pain and spasm while increasing
cellular survival and the levels of oxygenated blood delivered to damaged tissue.
Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of
cellular stress resistance and
improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20,
survival following induced ischaemic injury 21 and a reduction in oxidative stress.105