«As we identify which bacteria have a similar effect in humans, it should be possible to develop probiotic supplements that specifically
improve efficacy of immunotherapies,» he says.
«The most exciting finding was that TAM reprogramming greatly
improved the efficacy of immunotherapy,» says Michele De Palma.
Our objective is to use our microbiome therapeutic approach to
improve the efficacy of immunotherapy in patients with life - threatening cancers.»
Not exact matches
The ultimate goal
of Dr Janji's research team is to provide the proof
of concept that targeting autophagy could
improve the
efficacy of current
immunotherapies, notably those based on immune checkpoint blockades.
Seres is developing SER - 401, a preclinical stage oral microbiome therapy comprising a consortium
of live bacteria to
improve the
efficacy and safety
of immunotherapy.
However, it could dramatically
improve the
efficacy of current
immunotherapy drugs, which now have a 20 to 50 percent success rate.
«Immune checkpoint inhibitors, including PD - 1 and PD - L1 inhibitors, have provided meaningful clinical benefits for patients with cancer; however, novel
immunotherapy combination treatments are needed to
improve efficacy with limited additive toxicity,» said Aung Naing, MD, FACP, associate professor, Department
of Investigational Cancer Therapeutics, Division
of Cancer Medicine, The University
of Texas MD Anderson Cancer Center, Houston.