Sentences with phrase «improve mouse models of human disease»

Not exact matches

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

These mouse models are useful tools to improve our understanding of the biological significance and functional relevance of these polymorphisms in human disease, particularly when validated with controlled exposures and environmental challenges.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38