The original, randomized, open label study, which enrolled 20 outpatient men with cirrhosis and recurrent HE receiving standard - of - care (SOC) treatment, had previously reported that a single FMT enema after antibiotic pretreatment
improved cognitive function at Day 20 and reduced HE
episodes and hospitalizations
over the following 5 months compared with SOC.1 The long - term outcomes of this study, which were presented today at The International Liver Congress ™ 2018 in Paris, France, demonstrated sustained and statistically significant reductions in the number of HE
episodes and hospitalizations as well as improvements in cognitive function
over 1 year in the men who received FMT compared with the control group.
However, even though Sapienza is an
improved episode over the first one, we still can't shake the feeling that the newest iteration of Hitman would benefit much more if it was offered in one complete package instead of following the episodic approach.
Psychoeducation can significantly reduce relapse and
improve functioning,
over and beyond
improving medication adherence.28 Recently published 5 - year outcomes of group - based psychoeducation show enduring benefits, with fewer
episodes of illness and higher levels of functioning, in comparison to non-structured group meetings.27