Sentences with phrase «improved models of disease»

Caribou is pursuing near - term opportunities to develop the platform to engineer improved models of disease and for improved biomaterial production.

Not exact matches

«This research has broad impact, because by deepening our understanding of cell reprogramming we have the potential to improve disease modeling and the generation of better sources of patient - specific specialized cells suitable for replacement therapy,» said Plath.

Recently research published in Cancer Discovery showed that changing the schedules of drug administration can improve outcomes leading to more complete responses in mouse models of the disease.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

They hope that these achievements might also serve as a model for improving the management of other disease stages and settings.

Now, in an article published in Disease Models & Mechanisms, a team from the University of Alabama at Birmingham and Stanford University School of Medicine describe the use of a BDNF loop domain mimetic to improve motor function and object location memory in a mouse model of Rett syndrome.

Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.

Several laboratories, including one led by Stewart Anderson of the University of Pennsylvania Perelman School of Medicine, have demonstrated that transplanting inhibitory neurons from healthy mice has improved symptoms in mice with models of those diseases.

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

Using two complementary approaches to reduce the deposits of amyloid - beta in the brain rather than either approach alone improved spatial navigation and memory in a mouse model of Alzheimer's disease.

Drugs capable of activating silenced genes improve survival and growth outcomes in a mouse model of Prader - Willi syndrome (PWS), a rare and incurable childhood disease, according to a study funded by the National Institutes of Health (NIH).

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

Aerosol delivery of curcumin reduced abeta deposition and improved cognitive performance in a transgenic mouse model of Alzheimer's disease.

Thus there is an urgent need for systematically studying, improving and assessing the suitability of different animal models for different diseases.

FOA encourages research grant applications from institutions / organizations that propose to develop, characterize or improve animal models for human disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes.

Early Intervention with an Estrogen Receptor β - Selective Phytoestrogenic Formulation Prolongs Survival, Improves Spatial Recognition Memory, and Slows Progression of Amyloid Pathology in a Female Mouse Model of Alzheimer's Disease.

Injecting breast cancer with oxygen - filled microbubbles makes tumors three - times more sensitive to radiation therapy and improves survival in animal models of the disease.

WashU biomedical scientist G.S.M Sundaram, PhD., holds a model of the molecule fluselenamyl, which may improve PET scans for patients with Alzheimer's disease.

This work provided greater mechanistic understanding of airway remodeling that occurs as a result of viral exacerbation in respiratory diseases and an improved model for predicting the response to therapeutic candidates.

This earlier period of disease identification presents a valuable model for early intervention and improved assessment of potential therapeutic approaches for ALS.

The first accurate mouse model of an aggressive childhood muscle cancer has improved researchers» understanding of the cause of the disease and could accelerate the identification of new...

Clinicians and investigators in the fields of veterinary and human endocrine oncology, clinical trials, pathology, and drug development will be joined in this consortium, in order to improve knowledge, development of, and access to naturally occurring canine endocrine tumours, as a model for human disease.

My research goal is to improve a mouse model of this disease by introducing pro-inflammatory cues, and to experiment with a method of decreasing inflammation in the eye to test the idea that localized control of inflammation could help protect vision.

The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the disease.

LONDON (July 16, 2017)-- Researchers have found cell receptors abnormally overexpressed in post-mortem brains of those with Parkinson's and Alzheimer's diseases, and that they can be inhibited in animal models to clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance.

A new study shows that increasing the activity a critical piece of machinery called «mTORC1» in a mouse model of Huntington's disease leads to improved motor problems and brain abnormalities associated with the disease.

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

Determining the mechanism for these sex - based differences in airway inflammation and the contribution of the microbiome in animal models would improve our ability to treat or prevent asthma and other autoimmune diseases in women.

In a study published in Neuron, Palop and his collaborators uncovered the therapeutic benefits of genetically improving these interneurons and transplanting them into the brain of a mouse model of Alzheimer's disease.

Targets of research range from basic molecular and cellular mechanisms, the manipulation of these mechanisms in animal models, analyses of the genes and gene products in cardiovascular disease, and clinical research that seeks to improve diagnosis and therapy for patients.

The lab is working to harness this mechanism to improve the clinical outcome in animal models of the many neurodegenerative disorders that have an inflammatory component, including ALS, Alzheimer's and Parkinson's diseases.

Our recent study has demonstrated that peripheral amylin treatment reduces the amyloid pathology in the brain of Alzheimer's disease (AD) mouse models, and improves their learning and memory.

Abstract: Our recent study has demonstrated that peripheral amylin treatment reduces the amyloid pathology in the brain of Alzheimer's disease (AD) mouse models, and improves their learning and memory.

http://onlinelibrary.wiley.com/doi/10.1002/asia.201600259/full Subcutaneous administration of cyclodextrin significantly improved spatial learning and memory deficits in Alzheimer disease mice model doi: 10.1084 / jem.20121239.

This earlier period of disease identification presents a valuable model in which to explore and improve future assessment of potential therapeutic approaches for ALS.

These mouse models are useful tools to improve our understanding of the biological significance and functional relevance of these polymorphisms in human disease, particularly when validated with controlled exposures and environmental challenges.

381/12: 00 Inhibition of CTR1 by antisense oligonucleotides in mouse model of Wilson's disease reduces copper accumulation and improves liver pathology.

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease.

Improved animal models of Parkinsonism are essential to advance our understanding of disease pathophysiology and for eventual testing of potential therapeutics.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38

Furthermore, in an animal model of Huntington's disease, prolonged survival, reduced disease - associated weight loss and improved motor function was observed in animals on an alternate - day fasting diet compared to animals fed ad libitum (49).

The integrated medicine approach to patient care is considered the future model for healthcare destined to transform the traditional disease centric model to one where scientific principles and extensive patient evaluation are combined to create a strategy capable of improving current health and laying a foundation for health and vitality lasting throughout the patient's life span.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

Animal models are necessary to develop improved diagnostics and therapeutics, as well as understanding the basic pathophysiology of common human laryngeal diseases.

This model is important in that it addresses a significant disease and can model how to identify and change human variables to better improve other aspects of the complex relationships that we have with domestic and companion animals.

«But we also show several avenues [for] how to improve crop models, including interactions between temperature and water stress, ozone stress, sub-cellular mechanisms or disease responses of plants.»