Sentences with phrase «improved models of human disease»

Not exact matches

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

«We think that by restoring the natural «microbial identity» of laboratory mice, we will improve the modeling of complex diseases of free - living mammals, which includes humans and their diseases,» said Barbara Rehermann, M.D., senior author of the paper.

FOA encourages research grant applications from institutions / organizations that propose to develop, characterize or improve animal models for human disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes.

Clinicians and investigators in the fields of veterinary and human endocrine oncology, clinical trials, pathology, and drug development will be joined in this consortium, in order to improve knowledge, development of, and access to naturally occurring canine endocrine tumours, as a model for human disease.

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

These mouse models are useful tools to improve our understanding of the biological significance and functional relevance of these polymorphisms in human disease, particularly when validated with controlled exposures and environmental challenges.

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38

Animal models are necessary to develop improved diagnostics and therapeutics, as well as understanding the basic pathophysiology of common human laryngeal diseases.

This model is important in that it addresses a significant disease and can model how to identify and change human variables to better improve other aspects of the complex relationships that we have with domestic and companion animals.