Several trials have demonstrated that the cardiomyocytes of rodents maintained
on IER become more resilient to ischaemic injury induced by occlusion of the left coronary artery 18, 21, 29, which translated into improved long - term survival following such injury in one study.21 In addition, within these studies, associations have been found between the cardiovascular
improvements and markers of oxidative stress 24, 30, inflammatory responses 18, 24, 29, 30 and increases in circulating
levels of adiponectin.29 Collectively, these reported changes in biochemical and
physiological cardiovascular risk factors would be expected to suppress atherosclerotic development and preserve cardiovascular health.