Whole brain radiotherapy (WBRT) significantly
improves tumor control in the brain after SRS, yet because of its association with cognitive decline, its role in the treatment of patients with brain metastases remains controversial.
SBRT appeared to
improve tumor control, as suggested by the initial study results for RTOG 0236.
The decreased tumor size and enhanced tumor rejection in DGKζ - deficient mice indirectly suggests that enhanced Erk signaling may be superior to enhanced NF - κΒ activation in facilitating T cell activity against tumor, especially because DKO mice did not exhibit
improved tumor control relative to DGKζ − / − mice.
Not exact matches
In addition to potentially
improving screening tests, the team believes their approach may someday help doctors
control CTC - induced metastasis, which the researchers say can be far more lethal than the original
tumor.
Researchers have created a new drug delivery system that could
improve the effectiveness of an emerging concept in cancer treatment — to dramatically slow and
control tumors on a long - term, sustained basis, not necessarily aiming for their complete elimination.
«Although both anti-CTLA-4 and anti-PD-1
improved tumor rejection, mice treated with anti-CTLA-4 exhibited superior
tumor control, suggesting the memory T - cell response by this agent is more durable,» said Allison.
Collectively, these data indicate that DGKζ − / − mice exert
improved control of orthotopically implanted KPC1242
tumors, compared with WT mice, in a manner that may result from changes in the number of intratumoral activated CD8 + T cells in DGKζ − / − mice.
Similarly, Cbl - b − / − mice and T cells lacking Cbl - b demonstrate
improved control of s.c. - implanted
tumors (23) and disseminated leukemia (32), along with decreased spontaneous
tumor formation in ATM − / − mice (23) and UV B - treated mice (24).
To
improve the therapeutic window of STING agonist, iTeos selected Cristal Therapeutics nanoparticle technology to
control the delivery towards the
tumor microenvironment.
But combined with RT, it may have also
improve local
control of the heart
tumor.
The surgery serves two purposes; it removes the primary
tumor which is necessary for cancer
control, but it also removes the source of pain, and may therefore dramatically
improve the quality of life of the patient.