Sentences with phrase «in brains of patients»

Amyloid protein forms clumps in the brains of patients, creating sticky plaques that lead to brain cell death.

BALTIMORE: And that's exactly what's troubling — any attempt to take the information that we do have about what's going wrong in the brains of patients with Alzheimer's, and then turn it into a therapy, has failed.

For example, if we block mutant huntingtin production in cells or animals with «gene silencing» techniques, how can we confirm that this treatment actually does what it's supposed to do in the brains of patients with HD?

Eventually, this accumulation results in clumps, or aggregates, that can be seen microscopically in the brains of patients who have died of HD.

She discovered that one protein in particular, fibrinogen, is abundant in the brains of patients with MS and may be to blame for the development of autoimmunity.

1/17/2008 Rapid Effects of Intensive Therapy Seen in Brains of Patients with OCD In a study that may significantly advance the understanding of how cognitive - behavioral therapy affects the brain, researchers have shown that significant changes in activity in certain regions of the brain can be produced with as little as four week... More...

Supporting the clinical relevance of this finding, the researchers also found that KIBRA is decreased in the brains of patients with Alzheimer's disease, which correlated with an increase in acetylated tau.

Whilst there is previous evidence that levels of dopamine are elevated in the brains of patients who already suffer from psychosis, there has been little known about whether these levels are altered prior to the first episode of the illness.

«My research sets out to understand how progression works in MS by studying how inflammation is maintained in the brains of patients, and to develop new treatments aimed at preventing disease progression,» he explains.

I have begun to investigate BIN1 expression and the isoform diversity in the brains of patients with AD.

«The group had the data in human stem cells and a fly model, but we really wanted to know whether we could see this in the brains of patients,» says Rothstein.

In one instance, they showed structures that plan and then activate movement, which tend to interact in one direction in control subjects, may have abnormal bidirectional interactions in the brains of patients with temporal lobe epilepsy.

Elongated fibres (fibrils) of the beta - amyloid protein form the typical senile plaques present in the brains of patients with Alzheimer's disease.

A new study casts doubts on a long - held theory about what goes awry in the brains of patients with Huntington's disease.

In the brains of patients with Alzheimer's disease (AD), amyloid precursor protein is broken apart, and the resulting fragments — β - amyloid peptides, or Aβ peptides — aggregate to form plaques.

Penn State researchers were the first to discover increased iron levels in the brains of some patients with the late - onset neurodegenerative disorders Parkinson's disease and Alzheimer's disease.

In the brains of patients with Alzheimer's, amyloid peptides aggregate to form oligomers and plaques that are thought to be responsible for the disease symptoms.

Researchers at Rice's Center for Theoretical Biological Physics used computer models to analyze proteins suspected of misfolding and forming plaques in the brains of patients with neurological diseases.

We have found that the dimers are preserved during the tissue extraction procedure used in the lab and are consequently identical to those in the brains of patients with AD.

«Beta - amyloid dimers found in brains of patients with Alzheimer's.»

Fried implanted hair - thin wires in the brains of patients at the David Geffen School of Medicine at U.C.L.A..

The ever - growing crowd of misfolded proteins form the aggregates seen in the brains of patients with neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

«We need to understand what these antibodies do in the brains of patients better,» he says.

He contends the vitamins neutralize an oxidized compound that causes hallucinations when it accumulates in the brains of patients.

The two main abnormalities of the disease are microscopic lesions called plaques and tangles, which occur in the brains of patients.

«Although previous research has shown that some head injury patients have these amyloid plaques shortly after the incident, these findings suggest these plaques are still present in the brains of patients over 10 years later.

Accumulations of plaques and tangles in the brains of patients with Alzheimer's disease were first observed more than a century ago.

A few molecules of the protein, they found, can trigger the formation of long protein fibers similar to those in the brains of patients with neurological disorders such as Creutzfeld - Jakob disease.

All these diseases share a common feature: abnormal buildup of a protein called tau in the brains of patients.

The work should help scientists understand precisely what goes wrong in the brains of patients and help them design better therapies, Costa says.

Using an MRI technique that is sensitive to certain byproducts of cell metabolism, including levels of glucose and acidity, University of Iowa researchers discovered previously unrecognized differences in the brains of patients with bipolar disorder.

Using a different type of MRI imaging, researchers at the University of Iowa have discovered previously unrecognized differences in the brains of patients with bipolar disorder.

A new study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging using magnetic resonance imaging (MRI) reports a link between reduced functional activation and reduced cortical thickness in the brains of patients with bipolar disorder.

Most recently, he noted, researchers reported in Science that sleep functions as a kind of «sewer system» for the brain, at least in mice, by flushing beta - amyloid, which is known to accumulate in the brains of patients with Alzheimer's disease.

The link between depression and the immune system has been shown using positron emission tomography using a tracer for the translocator protein (TSPO) showing increased immune activation in the brains of patients with major depressive disorder compared with control subjects.

«New findings about stem cells in the brain of patients with epilepsy.»

German physician Aloysius «Alois» Alzheimer (left) first described the disease that would bear his name after finding altered proteins in the brain of his patient Auguste Deter (right).

The UCLA researchers, led by David Eisenberg, director of the UCLA - Department of Energy Institute of Genomics and Proteomics and a Howard Hughes Medical Institute investigator, report the first application of this technique in the search for molecular compounds that bind to and inhibit the activity of the amyloid - beta protein responsible for forming dangerous plaques in the brain of patients with Alzheimer's and other degenerative diseases.

Let's say I understand precisely what is going wrong in the brain of a patient.

In the case of Parkinson's disease, it is found that the expression of MAO - B, but not MAO - A, is significantly enhanced in the brain of patients and increases with age.

We have just started a multicenter trial using simvastatine to reduce inflammation in the brain of patients with schizophrenia.

Combined with previous studies on other disorders, the new study suggests that L1 genes are indeed more active in the brain of patients with neuropsychiatric diseases, Gage says.

So we documented plasticity in the brain of the patient.

For the first time since the disease was described 109 years ago, researchers affiliated with the University of Montreal Hospital Research Centre (CRCHUM) have discovered accumulations of fat droplets in the brain of patients who died from the disease and have identified the nature of the fat.

«We found fatty acid deposits in the brain of patients who died from the disease and in mice that were genetically modified to develop Alzheimer's disease.

Pierre has published two papers describing BIN1 physiological expression in the brain and its relation with tau tangles in the brains of patient with AD.

«Our approach allowed us to grow human neurons in a dish that contained the exact same mutation as the neurons in the brain of the patient,» explained first author Helen Fong, PhD, who is also a California Institute for Regenerative Medicine postdoctoral scholar.

However these compounds were designed as competitive antagonists to be active in the brain of patients having low concentration of adenosine whereas high levels adenosine are produced by ectonucleotidases, especially CD73 and CD39 that are overexpressed in the tumor microenvironment.

Although the genetic evidence strongly supports the targeting of γ - secretases (Szaruga et al, 2017; Voytyuk et al, 2017) to lower amyloid - β generation in the brain of patients, the severe side effects observed in phase 3 clinical trials have brought γ - secretase research almost to an end (Doody et al, 2013; De Strooper, 2014).

Not exact matches

The patient died of cerebral edema (brain swelling)-- a deadly adverse event that also afflicted Kite competitor Juno Therapeutics» rival drug in the space, which it was then forced to abandon.