Sentences with phrase «in ctl»

Comparing the pre-intervention and intervention periods, the TM group exhibited a non-significant decrease of 0.5 tardies compared to an increase of 0.6 tardies in the CTL group (F 1,39 = 0.3, p = ns).

In this CTL Associate Call, our CTL Board will be leading a discussion about best practices for coaching clients who are in career transition, looking to advance their career, working to improve their leadership skills, and beyond.

In this CTL Associate Call, our CTL Board will be leading a discussion about recruitment trends and what this means for our clients who are job seeking.

The 3 - year - mean anomalies correspond to a, b 240 — 242, c, d 243 — 245, and e, f 246 — 248 model years in CTL run or 1 — 3, 4 — 6, and 7 — 9 years lead in the hindcast experiment.

Niño 3.4 index is obtained from SST anomalies (5 ° S — 5 ° N, 170 ° W — 120 ° W) in the CTL run or ERSST for the 1850 — 2012 period.

It remains uncertain what role Atlantic SST anomalies play in generating the low - frequency Pacific wind response and the simulated North American precipitation anomalies in CTL.

Temporal evolution for three - year - mean anomalies of SLP (contoured) and total water storage (shaded; units are mm) in CTL and the ensemble mean of hindcast run initialized in 240.

(a, b) Annual - mean sea ice concentration in the CTL and SW experiments, and (c) SST anomalies during the last 50 years of the latter simulation.

(d, e) Total area of Arctic sea ice and AMOC volume transport as a function of time in the CTL, LW, and SW experiments.

7031.1 contains residues from all 3 regions linked by proline residues.Regions may be involved in CTL responses.

Not exact matches

CenturyLink (CTL) and Rackspace (RAX) held their own year over year, according to the report, which ranks providers in terms of their execution and «completeness of vision.»

CTL has not earned an economic profit in any year in our model dating back to 1998.

In 2003, he founded the Center for Teaching and Learning (CTL) at an independent high school in CaliforniIn 2003, he founded the Center for Teaching and Learning (CTL) at an independent high school in Californiin California.

After teaching in New York, Atwell moved to Maine, where in 1990 she founded CTL to experiment and share new ideas of teaching writing and reading.

But if you hold down ctl while scrolling up, that should zoom in and make everything easier to read.

They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.

Histone deacetylase (HDAC) inhibitors have shown promise in «flushing out» HIV from latently infected cells, potentially exposing the reservoirs available for elimination by cytotoxic T lymphocytes (CTL), also called killer T cells.

Arguing that «this high degree of complexity both in terms of immunological outcomes and underlying mechanisms, necessitates that HDAC inhibitors be studied in a context that is matched to their intended utility,» Brad Jones, from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Boston, USA, and colleagues set out to test whether the three drugs affected the ability of CTL to eliminate HIV - infected target cells.

However, findings published on August 14th in PLOS Pathogens now suggest that treatment with HDAC inhibitors might suppress CTL activity and therefore compromise the «kill» part of a two - pronged «flush - and - kill» HIV eradication strategy.

We performed single - cell RNA sequencing in more than 9000 cells to unravel CD4 - CTL heterogeneity, transcriptional profile, and clonality in humans.

We identified distinct clusters of CD4 - CTL effector and precursor cells in the TEMRA subset; the precursor cells shared TCR clonotypes with CD4 - CTL effectors and were distinguished by high expression of the interleukin - 7 receptor.

However, little is known in humans about the biology of CD4 - CTL generation, their functional properties, and heterogeneity, especially in relation to other well - described CD4 + memory T cell subsets.

Our identification of a CD4 - CTL precursor population may allow further investigation of how CD4 - CTLs arise in humans and, thus, could provide insights into the mechanisms that may be used to generate durable and effective CD4 - CTL immunity.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

This is the first reported immune intervention demonstrating a manipulation of the CTL immunodominance pattern and a durable viremic control of HIV - 1 infection in a large proportion of participants.

However, this in vitro boosting culture protocol did not induce de novo CTL activity in cells from naïve mice.

In our study, CD8 − T cells from CD4 KO rejector mice failed to display CTL or DTH activity, yet they were capable of inducing donor - specific apoptosis of corneal endothelial cells.

The results of a typical experiment are shown in Figure 3 and demonstrate that even though spleen cells from CD4 KO mice could adoptively transfer corneal allograft rejection, they did not display conventional CTL activity against either BALB / c corneal epithelial or endothelial cells.

In collaboration with Pedro Romero, Vincenzo Cerundolo and colleagues demonstrate that, unlike virus - specific CTLs, the highest frequency of tumor - specific CTLs can be found in tumor - infiltrated lymph nodeIn collaboration with Pedro Romero, Vincenzo Cerundolo and colleagues demonstrate that, unlike virus - specific CTLs, the highest frequency of tumor - specific CTLs can be found in tumor - infiltrated lymph nodein tumor - infiltrated lymph nodes.

CTLS 2016, organized by EMBL, aims to bring together not only scientists, technicians and managers, but also decision makers and opinion leaders involved in Core Technology facilities and resource laboratories in all fields of Life Science.

Building on the success of CTLS 2014 in Paris, this meeting will be a unique opportunity to listen and discuss with colleagues and peers about challenges and solutions on all scientific, technological, managerial funding, educational and community building aspects of core facilities and infrastructures.

The capacity of CD8 + T cells to mediate corneal allograft rejection could have been due to the CTL population that might have been present in the CD8 + T cell suspensions used in the adoptive transfer inocula.

By contrast, spleen cells from naïve C57BL / 6 mice did not develop detectable CTL, even after a four - day in vitro boost with BALB / c stimulator cells.

However, in vitro assays using spleen cells from CD4 KO mice that had rejected BALB / c corneal allografts failed to detect CTL activity against donor corneal epithelial or endothelial cells.

Treatment with HMGB1 inhibitors diminishes CTL - induced liver disease in HBV transgenic mice.

Studies in CD8 knockout (KO) and perforin KO mice demonstrated that CD8 + cytotoxic T lymphocytes (CTL) are unnecessary for the rejection of corneal allografts in mice (8, 9).

Spleen cells were isolated 7 — 14 days after C57BL / 6 CD4 KO mice had rejected BALB / c corneal allografts and were tested for anti - BALB / c CTL in a conventional 4 - hr 51Cr - release assay using BALB / c corneal epithelial and endothelial target cells.

We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB / c WEHI mice infected at birth with LCMV Armstrong strain.

Consequently both effector cells can operate in tandem, with NK cells providing a first line defense killing target cells that escape CTL recognition or show inadequate expression of self - MHC 142.

The suppression of LCMV - specific CTL responses by carrier spleen cells is not mediated by a suppressor cell, but is due to the presence of genetic variants of LCMV in spleens of carrier mice.

In striking contrast, wild - type LCMV Armstrong, from which these variants were generated, induces a potent CTL response in immunocompetent mice and the LCMV infection is rapidly cleareIn striking contrast, wild - type LCMV Armstrong, from which these variants were generated, induces a potent CTL response in immunocompetent mice and the LCMV infection is rapidly clearein immunocompetent mice and the LCMV infection is rapidly cleared.

Shell states that tar sands are less damaging that coal: Well since when was coal and oil used to the same ends unless they are talking about widespread adaption of CTL technology which could happen in some countries with large scale coal rserves I guess but even I doubt that CTL projects will scale to 3 — 5 mbpd which is the projected output of Albertas oil sands come 2030.

The transfer of spleen or lymph node cells containing LCMV - specific CTL resulted in virus clearance and prevented establishment of the carrier state.

Our results show that LCMV variants that emerge during infection in vivo play a crucial role in the suppression of virus - specific CTL responses and in the maintenance of virus persistence.

Such virus variants selectively suppress LCMV - specific CTL responses and cause persistent infections in immunocompetent mice.

The targets for this suppression are DC, CD4 + Th, CD8 + CTL and NK cells; in effect MSC silence each aspect of the cellular rejection process.

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