Sentences with phrase «in cell cycle»

Moreover, models of experimental carcinogenesis in animals have shown the potential to modify a number of metabolic actions and steps in the cell cycle in a way that early events in the cascade of cancer development may be counteracted while stages of progression may be slowed down.

Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.

Because C - di - GMP controls many different cell functions, the researchers believed it was highly likely that it manages its regulatory workload by appearing in the right amount, in the right place, at the right time in the cell cycle.

At the time, other groups had recently discovered particular proteins that disappear at certain points in the cell cycle.

CBX2 overexpression in breast tumors was associated with the upregulation of genes involved in cell cycle progression and is associated with poorer 5 - year survival.

51/2: 30 RNA sequencing of a mouse model of spinal muscular atrophy reveals tissue - wide changes in splicing of U12 - dependent introns in genes involved in cell cycle, intracellular trafficking, and neuronal function.

Downregulated clusters include mostly genes that take part in cell cycle, proliferation and metabolism, as well as genes that have been implicated in the maintenance of ES cell pluripotency (Table 2).

Figure 7 depicts a stationary view of the KEGG pathways for «Cell Cycle» and «Apoptosis» at three time points; it appears that ES cells (day 0) have higher numbers of expressed genes involved in cell cycle (rectangles in red color) compared to differentiated cells (day 10).

Our new study uses transcriptomics of cell fragments of the ciliate Stentor to reveal the importance of protein phosphorylation, microtubule - based processes and genes involved in the cell cycle for cellular regeneration.

Gadd45b plays a role in cell cycle arrest, and it is a positive mediator in Fas - induced apoptosis when a DNA injury appeared in nonneoplasic cells [28].

Here, we show that AZA responders have more hematopoietic progenitor cells (HPCs) in the cell cycle.

We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.

The restriction of cellular growth by p53 has been reported to result in cell cycle arrest or apoptosis [6], and targeting p53 and restoring p53 function to limit tumor growth has been intensively researched for cancer therapy [7].

This effect on growth inhibition was not due to alterations in cell cycle (Supplemental Fig. 5) nor a significant increase in the apoptotic cell populations, suggesting that RIPK2 inhibition of proliferation is independent of cell cycle or apoptotic changes.

Pestell's research in cell cycle, prostate cancer, oncology and stem cells is highly cited; he is ranked first in the world by Google scholar citations in cell cycle and prostate cancer, and second in the world for oncology.

This contradictory behavior explained that Cyclin D1 acts as a negative regulative protein under some conditions rather than a positive regulator in the cell cycle, i.e. the modest increase in Cyclin D1 expression could hasten the G1 phase while the overexpression may lead to block the progression through the S - phase [28, 29].

They also can play very complex regulatory roles in the cell cycle control, cell migration, inflammation or apoptosis.

Over the course of evolution, organisms have developed variations in their cell cycle programs to be able to generate and maintain a plethora of different cell types and tissues.

Our lab uses a variety of model systems, such as the nematode C. elegans, as well as in vitro culture systems, to address fundamental questions in cell cycle control during development and tissue formation.

Jana Sontheimer (Pisabarro, TUD)-- «Functional characterization of proteins involved in cell cycle by structure - based computational methods» (2012)

Furthermore, niclosamide inhibited not only signal transduction, but also targeted mitochondria in cancer cells resulting in cell cycle arrest, growth inhibition and apoptosis [49 - 51].

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

Furthermore; p16INK4a inhibits CDK4 and CDK6, and induces phosphorylation of the protein retinoblastoma (Rb) and liberating the transcription factor E2F which consequently result in cell cycle progression [29].

Key findings of this research, which was conducted by Shawn L. Chavez, PhD and her colleagues at Stanford University and analyzed at OHSU, showed that by looking at the duration of the first mitotic phase — a short period in the cell cycle — one can identify chromosomally normal versus abnormal embryos up to approximately the 8 - cell stage.

LA JOLLA, CA — A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells.

They found that like bacteria and budding yeast, H. salinarum controls its size by adding a constant volume between two events in the cell cycle.

The researchers had noticed, for instance, that the length of individual stages in the cell cycle varied from cell to cell, while the length of the overall cycle was much more consistent.

One group of drugs — primarily targeting machinery involved in the cell cycle, protein chaperoning or DNA repair — elicited similar patterns of response across all cell lines.

His team discovered these special sequences are distributed throughout the human genome, embedded in multiple genes as shown in the study in Cell Cycle.

Although the biological mechanisms through which this polymorphism could affect aging are not known, it is adjacent to two genes called CDKN2A and CDKN2B, which play an important role in cell cycle regulation.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Pérez de Castro, who are experts on protein AURKA and its role in the cell cycle.

Firstly, salt stress causes a delay in cell division, leading to synchronization of cell cycles; secondly, survival probability depends on the individual bacterial cell's position in the cell cycle at the time of the second exposure.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

The role of DNA topology in holding sister chromatids together before anaphase was investigated by analyzing the structure of a small circular minichromosome in cell cycle (cdc) mutants of the yeast Saccharomyces cerevisiae.

It was always «fun» to discuss and argue scientific matters with Kim — he is a very effective experimenter and, as everyone in the cell cycle field knows, an unusually bright mind.

I had spent 4 years studying the interactions between two proteins involved in the cell cycle and DNA replication and repair.

Yet they have a version of p53 that is strikingly similar to ours, David Lane, of Cancer Research UK, reports in research to be published in Cell Cycle.

We observed a modest decrease in cell cycling and some induction of the neuronal marker beta - III tubulin, as quantified here.

Not exact matches

Nerve cells in our brains control our circadian rhythms, which influences sleep - wake cycles, hormone release, emotions and energy levels.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

At Key Stage 3 (age 11 to 13 +, Years 7 to 9) schools have to teach: that fertilisation in humans and flowering plants is the fusion of a male and a female cell; about the physical and emotional changes that take place during adolescence; about the human reproductive system, including the menstrual cycle and fertilization; how the foetus develops in the uterus, including the role of the placenta.

They found that epigallocatechin gallate, or EGCg, which is found in all tea, inhibits the activity of tNOX, an overactive enzyme that interferes with a cell's divide - and - rest cycle, and can facilitate uninterrupted growth of cancerous cells when combined with other factors.

In a non-psoriatic person, skin cells typically cycle (grow and shed) every three weeks.

One new development in the 2010 election cycle was the first significant use of mobile advertising, particularly ads on the cell phone - optimized versions on websites and search engines.

One particularly interesting use of cell phones for fundraising in the 2008 election cycle: the John Edwards campaign contacted list members via text, urged them to call a number and listen to a recorded message, then connected them to operators to take donations right away.

I reached MacKay on his cell phone after this afternoon's endorsement press conference — the Indy Party's first official nod in this election cycle.

He spent his last year as a Lisbon student studying cell - cycle regulation in yeast at the University of Manchester in the United Kingdom, with an Erasmus scholarship from the European Commission.

Nathaniel Hoyle of the MRC Laboratory of Molecular Biology in Cambridge, UK, and his colleagues have discovered that genes in a type of skin cell switch on and off during day - night cycles.

In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellIn November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin cultured cells.

The cycle persists even in decapitated flies, demonstrating that the malpighian cells are not merely responding to signals from the insects «brains.