Sentences with phrase «in cell metabolism on»

In Cell Metabolism on August 13, the Harvard scientists who discovered irisin address this contentious issue by showing that human irisin circulates in the blood at nanogram levels and increases during exercise.

Not exact matches

An acid condition has several adverse effects on cell metabolism, including impaired energy production, fluid accumulation and edema, and a likely increase in free radical production.

The study, recently published in Cell Metabolism, also found that beige fat, unlike the better - known white and brown fat, has interesting anti-diabetic effects on blood sugar metabolism that seem independent of temperature rMetabolism, also found that beige fat, unlike the better - known white and brown fat, has interesting anti-diabetic effects on blood sugar metabolism that seem independent of temperature rmetabolism that seem independent of temperature regulation.

The cause of this phenomenon has so far been attributed to the thyroid hormones» general effect on the metabolism in the cells themselves.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs - small RNA molecules that play important roles in regulation in many types of tissue — play a major role in the distribution and determination of fat cells and whole body metabolism.

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

In their efforts to conquer the aging process, researchers are zeroing in on one specific part of the cell: mitochondria, the energy - generating organelles that control our metabolism and, it seems, help regulate how long we livIn their efforts to conquer the aging process, researchers are zeroing in on one specific part of the cell: mitochondria, the energy - generating organelles that control our metabolism and, it seems, help regulate how long we livin on one specific part of the cell: mitochondria, the energy - generating organelles that control our metabolism and, it seems, help regulate how long we live.

We would know the basic structure of every last one of its proteins: every enzyme in its metabolism, every signal - bearing hormone coursing through its body, every receptor poised to receive those signals on the surface of its cells.

After completing her graduate studies in 2006, she joined the laboratory of Dr. Craig B. Thompson at the University of Pennsylvania for postdoctoral work focusing on cancer cell metabolism.

We also observed a strong increase in the production of GLP1 in the gut cells, thus proving the crucial role of the intestine in the control of carbohydrate balance and the influence of estrogens on the entire metabolisms at stake.»

In a study published today in Cell Metabolism, UT Southwestern researchers identify a hormone that acts on the brain to increase the desire to drink water in response to specific nutrient stresses that can cause dehydratioIn a study published today in Cell Metabolism, UT Southwestern researchers identify a hormone that acts on the brain to increase the desire to drink water in response to specific nutrient stresses that can cause dehydratioin Cell Metabolism, UT Southwestern researchers identify a hormone that acts on the brain to increase the desire to drink water in response to specific nutrient stresses that can cause dehydratioin response to specific nutrient stresses that can cause dehydration.

In addition to 6 - PN, Bolton and her colleagues studied 8 - prenylnarigenin (8 - PN), isoxanthohumol (IX) and xanthohumol (XH) for their effects on estrogen metabolism in breast cellIn addition to 6 - PN, Bolton and her colleagues studied 8 - prenylnarigenin (8 - PN), isoxanthohumol (IX) and xanthohumol (XH) for their effects on estrogen metabolism in breast cellin breast cells.

Craig Thompson, president of the Memorial Sloan - Kettering Cancer Center in New York City, yesterday was hit with a second lawsuit alleging that he made an improper business deal to exploit his research on the metabolism of cancer cells.

Lead author Nora Volkow, a psychiatrist at the National Institute on Drug Abuse of the National Institutes of Health, recruited 47 healthy volunteers and used positron emission tomography (PET) scans to measure glucose metabolism in the brain while cell phones were placed over the right or left ear.

He and his colleagues report their results on 19 May in Cell Metabolism.

«Boosting serotonin signaling has been seen as a viable strategy for weight loss in people, but our results hint that boosting serotonin plus adrenaline should produce more potent effects — and there is already some evidence that that's the case,» said TSRI Assistant Professor Supriya Srinivasan, who was principal investigator for the study, published online before print on October 10, 2013 by the journal Cell Metabolism.

The results, revealing new examples of heritable bacterial species — including those related to diet preference, metabolism, and immune defense — appear May 11 in Cell Host & Microbe's special issue on the «Genetics and Epigenetics of Host - Microbe Interactions.»

The structure of this complex, determined using cryo - electron microscopy, shows how it converts near - infrared light into an electrical charge in order to power cell metabolism, which enables this bacterium to live at the extreme red limit of photosynthesis on Earth.

The basics of glycogen biology are thought to be well established, but a study in rodents published July 5th in the journal Cell Metabolism turns long - standing assumptions on their head.

The research was published online on October 8th in the journal Cell Metabolism.

They were surprised to discover that it also had an enormous impact on metabolism in cells — how fast cells can convert nutrients into energy — throughout the course of a day.

«This study breaks new ground because it focuses on boosting beta cell performance and shows that beta cell preservation is possible even in the face of such immune attack,» said senior author Gökhan S. Hotamisligil, chair of the Department of Genetics and Complex Diseases and J.S. Simmons Professor of Genetics and Metabolism at HSPH.

The light or «autoflorescence» produced changes according to the chemical reactions or metabolism going on in the cell.

In this schematic of the new «liver on a chip» device, adding blood - sugar - raising glucagon to inlet 1 and blood - sugar - lowering insulin to inlet 2 distributes the hormones across the field of hepatocytes (purple box) along opposing gradients, altering the cells» metabolism from glucose release on the left side to glucose uptake on the right.

«Additionally, we showed that obesity increases the number and activity of NK cells in abdominal fat but not in other tissues,» says Lee, senior author on a paper published online in Cell Metabolism.

«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory cell type dependent on glucose metabolism in the absence of oxygen.

Not only were levels of metabolic compounds different, but the expression of certain genes involved in metabolism was turned up, and the epigenome of the cells — molecular markers on DNA that change gene expression on a broader scale — was altered.

«Our original hypothesis was that cancer cells were modifying their metabolism based on communications they were receiving from cells in the microenvironment near the tumor,» said Nagrath, assistant professor of chemical and biomolecular engineering at Rice and co-author of a new study describing the research in the open - access journal eLife.

Now, however, a team of researchers led by Yu - Hua Tseng, Ph.D., Investigator in the Section on Integrative Physiology and Metabolism at Joslin Diabetes Center and an Associate Professor of Medicine at Harvard Medical School, has created cell lines of human brown and white fat precursor cells that will help investigators to pick apart the factors that drive the development and activity of each type of cell.

Zinc finger nuclease mediated knockout of ADP - dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.

Their work was reported online in the journal Cell Metabolism on November 30.

Yu - Hua Tseng, Ph.D., is an Investigator in the Section on Integrative Physiology & Metabolism at Joslin Diabetes Center, Assistant Professor of Medicine at Harvard Medical School, and Principal Faculty of the Harvard Stem Cell Institute.

So what I mean by that is, metabolism is basically the housekeeping chemical processes that are going on in the cell.

Better understanding of the beta - cell proliferation process eventually may lead toward therapies for diabetes patients, whose supplies of these cells often shrink over time, says Rohit Kulkarni, M.D., Ph.D., a Joslin Senior Investigator and senior author on a paper about the work published in the journal Cell Metabolcell proliferation process eventually may lead toward therapies for diabetes patients, whose supplies of these cells often shrink over time, says Rohit Kulkarni, M.D., Ph.D., a Joslin Senior Investigator and senior author on a paper about the work published in the journal Cell MetabolCell Metabolism.

Despite their lack of cBAT, the mutant mice were able to «maintain their body temperature perfectly,» says senior author Yu - Hua Tseng, Ph.D., Assistant Professor of Medicine at Harvard Medical School, Principal Faculty of the Harvard Stem Cell Institute and an Investigator in the Section on Integrative Physiology and Metabolism.

Studies in cells and genetically modified mice show that the regulatory subunit of the PI 3 - kinase, a protein called p85, works both ways, says C. Ronald Kahn, M.D., Head of the Joslin Section on Integrative Physiology and Metabolism, and senior author on a Nature Medicine paper reporting the discovery on March 28.

Panels B — D. mRNA expression analysis of genes involved in glycogen metabolism (Panel B), gluconeogenesis (Panel C), and insulin signaling (Panel D), as quantified by transcriptome analysis, was performed in enhanced hiPS - HEP cells from C12, C18, and C22 on Day 12 post-thawing (n = 2 batches per cell line) and compared to gene expression measurements performed on hphep cells on Day 1 post-thawing (n = 3 donors).

Now available in the Early Edition of PNAS: Tom Williams (University of Bristol, UK) in collaboration with, among others, the Ettema - lab reports on using integrative modeling of gene and genome evolution to root the archaeal tree of life and to resolve the metabolism of the earliest archaeal cells.

Biochemical reactions that are responsible for the metabolism of living organisms do not proceed in a test tube: most of them take place in a confined space of a cell, on or even within a biological membrane.

Tom Williams (University of Bristol, UK) in collaboration with, among others, the Ettema - lab reports on using integrative modeling of gene and genome evolution to root the archaeal tree of life and to resolve the metabolism of the earliest archaeal cells.

Results of the study from Eric Verdin's lab at the Buck Institute for Research on Aging in Novato, CA are published in the September 5th issue of Cell Metabolism.

«So a cell that rewires its metabolism early on to scarf up nutrients from the environment is more likely to do what the tyrosine kinase pathway sets in motion; it's more likely to have all the things it needs to become a tumor.»

Jared Mayers (Brigham and Women's Hospital Boston, USA), winner of the prize category Translational Medicine, kicked the event off with his research on differences in how cancer cells and normal cells utilize of nutrients and how this has been linked to genetic changes in cancer, opening up an opportunity for drugs targeting metabolism.

T - Cell Enzyme Uses Deadly Multipronged Attack on Bacteria — GEN News Paper: Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program — Farokh Dotiwala — Cell

Different factors, including the free radicals that are a byproduct of oxygen metabolism, result in Top1ccs becoming trapped on DNA and accumulating in cells.

But in human cells, scientists noticed apoE4 has a very clear effect on increasing amyloid beta production, which highlights the species difference in the way apoE4 controls amyloid beta metabolism.

«This research opens up an entirely new set of questions about the development of type 2 diabetes,» says Susan Bonner - Weir, a Joslin Senior Investigator and corresponding author on a paper describing the work in the journal Cell Metabolism.

JAX has particular strengths in research focused on understanding aging, behavior and addiction, computational biology, cancer, development and disease, gene expression, genetics and genomics, immunology and hematology, metabolism, microbiome, neuroscience, reproductive biology, statistical and population genetics, stem cells, systems biology, and translational medicine.

«Obesity may... promote estrogen production and breast cell proliferation, in addition to the direct effect alcohol can have on estrogen metabolism and levels in the body,» she explains.