Sentences with phrase «in cerebellar»

Citation: Shaw TA, McGonnell IM, Driver CJ, Rusbridge C, Volk HA (2012) Increase in Cerebellar Volume in Cavalier King Charles Spaniels with Chiari - like Malformation and Its Role in the Development of Syringomyelia.

Our results support hypothesis iii) which states that in CKCS an increase in relative cerebellar volume is correlated with an increase in cerebellar crowding in the caudal CCF.

Specificity - Probability of correct identification of the normal form of the gene implied in the cerebellar ataxia in a normal homozygous or heterozygous dog is higher than 99 %.

Intrinsic Plasticity Complements Long - Term Potentiation in Parallel Fiber Input Gain Control in Cerebellar Purkinje Cells.

Expression of the α3, α4, and α7 nAChR subunits in cerebellar cultured cells was examined by RT - PCR.

In cerebellar cultures from neonatal rats at postnatal day 1 (P1), approximately 90 % of the total cells were small neurons stained by anti-Tuj1 (neuron specific β3 - tubulin).

The α3, α4, and α7 nAChR subunits were expressed in cerebellar cells but not in kidney fibroblasts.

Insulin - like growth factor - I blocks Bcl - 2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

Inhibition of Rac GTPase triggers a c - Jun - and Bim - dependent mitochondrial apoptotic cascade in cerebellar granule neurons.

Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase - 3β and a caspase -9-dependent apoptosis in cerebellar granule neurons.

N - terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase - < i > independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress.

Repeated intermittent alcohol exposure during the third trimester - equivalent increases expression of the GABA A receptor δ subunit in cerebellar granule neurons and delays motor development in rats.

Calpain Plays a Central Role in 1 - Methyl -4-phenylpyridinium (MPP (+)-RRB-- Induced Neurotoxicity in Cerebellar Granule Neurons.

Repeated intermittent alcohol exposure during the third trimester - equivalent increases expression of the GABA < sub > A receptor δ subunit in cerebellar granule neurons and delays motor development in rats.

Note that attenuated decreases in cerebellar DV with MP in the marijuana abusers could result in an overestimation of their DA increases, reflecting an apparent lower striatal - DV / cerebellar - DV ratio (BPND) with MP (see below).

The long - term effect of Pkn1 knockout was further seen in cerebellar atrophy and mild ataxia.

The mechanism underlying the lack of an effect of MP in cerebellar DV in abusers is unclear but could reflect the effects of chronic marijuana on cerebrovascular reactivity (increased cerebral vascular resistance)(23 ⇓ — 25), which might have prevented MP - induced vasoconstriction and associated reductions in radiotracer delivery to the brain.

Because the study used cognitive stress as a challenge, it was not confounded by potential group differences in stimulant - induced changes in cerebellar radiotracer delivery.

Early in cerebellar development, particular cell types come to be distributed unevenly from top to bottom, creating a dorsal - ventral separation.

They also found evidence of reduced numbers of mitochondria and early mitochondrial deficiency in the cerebellar cortex.

And that would mean that researchers could next «look in a much more focused way [for] specific genes that might be involved in cerebellar development.»

Not exact matches

According to research by James Prescott, a developmental neuropsychologist and cross cultural psychologist, «vestibular - cerebellar stimulation (which happens when we carry our babies) is the most important sensory system for the development of «basic trust» in the affectional bonding between mother and infant.

This study, reported in the February 2015 issue of Experimental Biology and Medicine, utilized cultured cerebellar granule neurons, one of the most widely used models to study neuronal death.

The findings explain how cerebellar stimulation might have a therapeutic benefit in schizophrenia.

Compared to the brains of people without bipolar disorder, the researchers found that the MRI signal was elevated in the cerebral white matter and the cerebellar region of patients affected by bipolar disorder.

The UI study, which was published March 28 online in the journal Molecular Psychiatry, adds to the accumulating evidence, including recent human studies from Harvard University, that suggests cerebellar stimulation might help improve cognitive problems in patients with schizophrenia.

«Cerebellar interactions with the frontal cortex in cognitive processes has never been shown before in animal models,» says Parker, UI assistant professor of psychiatry and the first faculty hire of the new Iowa Neuroscience Institute.

The study also showed that, in control rats, the same delta wave activity occurred in the rat's cerebellum during the timing task and, interestingly, the cerebellar activity preceded the activity in the frontal cortex.

Early experimental studies from Harvard in patients with schizophrenia suggest that cerebellar stimulation is safe and appears to improve some of the patients» cognitive abnormalities.

«The million dollar question is whether mutations of this gene also occur in humans with cerebellar ataxia,» says Becker, who is screening people with genetic forms of the condition to find out.

The same neurons are destroyed in people with the disorder cerebellar ataxia, which causes unsteadiness and loss of coordination.

«The difference in ape cerebellar volume, relative to a scaled monkey brain, is equal to 16 billion extra neurons,» says Barton.

«Repetitive blast exposure causes cerebellar dysfunction in combat veterans: Researchers help bridge knowledge gap in brain injuries.»

Their findings, «Repetitive Blast Exposure in Mice and Combat Veterans Causes Persistent Cerebellar Dysfunction,» published in Science Translational Medicine January 13 are helping to uncover the mysteries of how combat veterans have been injured by repetitive blast exposure.

The decreased blood flow in the following six regions of the brain were the most important in determining who had football related health trauma: anterior superior temporal lobes, rolandic operculum, insula, superior temporal poles, precuneus and, cerebellar vermis.

In humans, the cerebellum's extensive connectivity with the rest of the brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception and cognition, with recent work linking cerebellar dysfunction to such complex diseases as schizophrenia and autisIn humans, the cerebellum's extensive connectivity with the rest of the brain suggests it does far more than learn motor skills: it has been shown to have a part in both perception and cognition, with recent work linking cerebellar dysfunction to such complex diseases as schizophrenia and autisin both perception and cognition, with recent work linking cerebellar dysfunction to such complex diseases as schizophrenia and autism.

In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD - like features.

RIKEN researchers have taken up this challenge, and the work published in Cell Reports details how sequentially applying several signaling molecules to three - dimensional cultures of human embryotic stem cells prompts the cells to differentiate into functioning cerebellar neurons that self - organize to form the proper dorsal / ventral patterning and multi-layer structure found in the natural developing cerebellum.

According to Dr. Gaffield, the sophisticated behavior tasks, used in combination with genetic reporters and effectors of activity, have opened up the possibility of studying cerebellar circuits during voluntary movement at an unprecedented level of quantitation.

These cells also showed early markers that are specific to developing Purkinje cells, granule cells, or deep cerebellar projection neurons — all types of neurons only found in the cerebellum.

To ensure that the DV responses in the controls were consistent with prior findings, we performed a secondary analysis on the effects of MP on the cerebellar DV in an independent cohort of controls, which showed a 12 % reduction, and in a sample of adults with attention deficit hyperactivity disorder (ADHD), which also showed an 11 % reduction (for controls of the current cohort, the cerebellar DV decrease was 13 ± 11 %).

In controls but not in marijuana abusers, MP reduced cerebellar DIn controls but not in marijuana abusers, MP reduced cerebellar Din marijuana abusers, MP reduced cerebellar DV.

CXCR4, along with its natural ligand CXCL12, plays a critical role in normal B cell, cardiovascular, and cerebellar development, though T lymphocytes appear to develop normally in cxcr4 − / − mice [51].

Here we identify protein kinase N1 (PKN1) as a novel key player in fine - tuning the balance between axonal outgrowth and presynaptic differentiation in the parallel fiber — forming (PF - forming) cerebellar granule cells (Cgcs).

Because the DV in cerebellum was not decreased by MP in marijuana abusers but was decreased in controls, this would result in an overestimation of the decrease in BPND with MP (cerebellar denominator would have a relatively larger value) and an overestimation of DA increases in marijuana abusers compared with controls.

Specifically, he investigated the effects of autoantibodies against NMDA receptor in the context of synaptic plasticity and learning and memory, and autoantibodies mGluR1, in the context of synaptic remodeling and cerebellar ataxia.

In immunoelectron microscopy the densities of CB1 - positive signals in hippocampal excitatory terminals and cerebellar PF terminals were much lower than in inhibitory terminals but were clearly higher than the backgrounIn immunoelectron microscopy the densities of CB1 - positive signals in hippocampal excitatory terminals and cerebellar PF terminals were much lower than in inhibitory terminals but were clearly higher than the backgrounin hippocampal excitatory terminals and cerebellar PF terminals were much lower than in inhibitory terminals but were clearly higher than the backgrounin inhibitory terminals but were clearly higher than the background.

Tonically active GABA - A receptors and electrical properties of cerebellar granule cells in the Ts65Dn mouse model of Down Syndrome

At climbing fiber (CF) and parallel fiber (PF) synapses on cerebellar Purkinje cells the cannabinoid - dependent suppression was absent in CB1 knock - out mice.

Spinocerebellar Ataxia Type 7 Cerebellar Disease Requires the Coordinated Action of Mutant Ataxin - 7 in Neurons and Glia, and Displays Non-Cell-Autonomous Bergmann Glia Degeneration.