Sentences with phrase «in human bone marrow»

Additionally, cells expressing MSC markers were found to localize to blood vessel walls in human bone marrow and dental pulp.

Clough BH, Zeitouni S, Krause U, et al., Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen ‐ Synthease ‐ Kinase ‐ 3 ‐ Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.

Not exact matches

While scientists have previously had success in 3D printing a range of human stem cell cultures developed from bone marrow or skin cells, a team from Scotland's Heriot - Watt University claims to be the first to print the more delicate, yet more flexible, human embryonic stem cells (hESCs).

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory - based study presented at the European Congress of Endocrinology in Dublin.

The researchers added human bone marrow stem cells from a non-diabetic donor to a bone fracture in laboratory pre-clinical studies.

Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these human stem cells, which are found in bone marrow.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cellIn humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cellin the multiple myeloma cells.

He points to recent success of partially matched bone marrow transplants in humans, shown to be equally as effective as fully matched transplants.

In a first step towards creating artificial sperm cells, researchers have turned human bone marrow tissue into primitive sperm cells.

Once Katlyn arrived in May 2007, Candotti and his team removed stem cells from her bone marrow and exposed them to the engineered retrovirus, creating a human - virus hybrid.

In experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weekIn experiments in mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weekin mice and human cells, researchers found that blocking CXCR4 — a so - called homing receptor protein molecule that helps T cells mature and attracts blood cells to the bone marrow — halted disease progression in bone marrow and spleen tissue within two weekin bone marrow and spleen tissue within two weeks.

• A Columbia University team headed by Silviu Itescu used human bone marrow to build new blood vessels in the hearts of rats.

The study developed a new in vitro system made from bone marrow stem cells and studied what would happen if its ambient temperature fell below 37 °C (the natural temperature of the human body).

• Piero Anversa at New York Medical College in Valhalla, New York, and Donald Orlic at the National Human Genome Research Institute in Bethesda, Maryland, used mouse bone marrow to repair damaged mouse hearts.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

BMT was effective in mice, but in humans resulted in death before the new bone marrow grew and expanded (called engraftment) in treated patients.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

Future research Because there are few salivary gland stem cells in the human mouth, the scientists plan to continue using rat salivary glands to refine the process, but eventually hope to use stem cells derived from human bone marrow or umbilical cord blood to regenerate salivary glands for humans.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

The first human bone marrow transplant was performed in 1956 by E. Donnall Thomas.

Pathologist Hinh Ly's research has made a connection between genetic defects in telomere maintenance and bone marrow failure syndrome in human patients.

Comparison of human adult stem cells from adipose tissue and bone marrow in the treatment of experimental autoimmune encephalomyelitis.

Human immunodeficiency virus (HIV) can infect bone marrow cells — including, possibly, hematopoietic stem cells, according to a study published online today (March 7) in Nature Medicine.

In close collaboration with universities and physicians world - wide, our comprehensive investigational stem cell treatments employ well - targeted combinations of allogeneic human umbilical cord stem cells, autologous bone marrow stem cells, and autologous adipose stem cells for the diseases listed below.

In separate experiments reported in Nature — one with mice, the other transplanting human stem cells into mouse bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cellIn separate experiments reported in Nature — one with mice, the other transplanting human stem cells into mouse bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cellin Nature — one with mice, the other transplanting human stem cells into mouse bone marrow — researchers demonstrated techniques with the potential to produce all types of blood cells.

Cytokinesis failure occurs in Fanconi anemia pathway — deficient murine and human bone marrow hematopoietic cells.

Osteogenic induction of human bone marrow - derived mesenchymal progenitor cells in novel synthetic polymer - hydrogel matrices.

Blood formation in the human embryo begins in the liver at about week 5 and at week 12 in the spleen, red bone marrow, and thymus.

Quantification of lipids in human lower limbs using yellow bone marrow as the internal reference: gender - related effects

Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells.

The study assessed safety and efficacy of intracoronary autologous transplantation of bone marrow - derived human MSCs in patients with acute myocardial infarction.

By studying how the rat body accepts or rejects transplanted pancreas, skin, heart, kidney, or bone marrow, scientists have helped medical doctors successfully perform life - saving transplants in human adults and children.

This groundbreaking work influenced many scientists investigating bone marrow transplant for humans, including the winner of the 1990 Nobel Prize in Physiology or Medicine.

Patients receive one of two types of stem cell - based transplants: autologous, in which a patient donates and receives back his / her own stem cells; or allogeneic, in which bone marrow - derived stem cells come from a related or unrelated donor whose human leukocyte antigens (HLA) are genetically matched with those of a patient.

In the recent study, the researchers used CRISPR snipped out the sickle cell mutation from donated human bone marrow cells, and replaced it with non-mutated DNA.

If successful, this may lead to therapies for humans in which a patient's stem cells will be reverted into iPSCs, then genetically repaired and transplanted back into the bone marrow of the same patient.

Human embryonic stem cells grown at the University of Wisconsin - Madison randomly changed into cell types found in the A) gut B) brain C) bone marrow D) cartilage E) muscle F) kidney Scientists haven't learned to control the development.

A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal - bone marrow: a simple and rapid method for the isolation of mouse central bone marrow.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

Rapamycin is a drug currently approved for immunosuppression during preparatory and maintenance regimens for organ and bone marrow transplant in human patients.

Well known for causing idiosyncratic (non-dose-dependent) anemia in people and dose - dependent bone marrow suppression in animals, its use in both human and veterinary medicine is increasing because of resistance to other antimicrobial drugs.

Bone marrow transplants for dogs is a relatively new procedure that involves the use of Leukophoresis machines — the same equipment used in human medicine — that are designed to harvest healthy stem cells from the peripheral blood.