Anticancer effects of niclosamide
in human glioblastoma.
Son et al., SSEA - 1 is an enrichment marker for tumor - initiating cells
in human glioblastoma.
Dr. Iavarone's paper is titled, «Transforming Fusions of FGFR and TACC Genes
in Human Glioblastoma.»
VIRUS VICTORY Zika virus (green) infects and kills stem cells (red)
in human glioblastoma tissue, without infecting healthy brain cells.
Not exact matches
In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alon
In human cells and
in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alon
in mice, the virus infected and killed the stem cells that become a
glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.
Using
human - derived
glioblastoma cells
in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.
The investigators report that trapping virus - loaded stem cells
in a gel and applying them to tumors significantly improved survival
in mice with
glioblastoma multiforme, the most common brain tumor
in human adults and also the most difficult to treat.
The team found that exposing samples of
human glioblastoma tumours grown
in a dish to the Zika virus destroyed the cancer stem cells.
Shah and his team loaded the herpes virus into
human MSCs and injected the cells into
glioblastoma tumors developed
in mice.
In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cell
In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels
in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cell
in cultured
human glioblastoma stem cells capable of tumor propagation than
in differentiated tumor cell
in differentiated tumor cells.
Several studies have supported a role for cancer stem cells
in the aggressive brain tumors called
glioblastoma, but those studies involved inducing
human tumors to grow
in mice, and as such their relevance to cancer
in humans has been questioned.
This new generation of viruses has been genetically «targeted and armed,» says Winald Gerritsen of the VU University Medical Center
in Amsterdam, who is involved
in an early
human trial of an engineered adeno - associated virus that attacks
glioblastoma, an aggressive form of brain cancer.
Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing
Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of
human glioblastomas but which, lacking tumor stem cells, were nothing
glioblastomas but which, lacking tumor stem cells, were nothing of the kind.
Another is that the transplanted bits of tumor act nothing like cancers
in actual
human brains, Fine and colleagues reported
in 2006: Real - life
glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well
in the lab, so they don't get transplanted into those mouse brains.
Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results
in mouse models of
glioblastoma, the most common brain tumor
in human adults.
It is a continuation of previous research, published
in 2011, that focused on the effect of decitabine on
glioblastoma human cell cultures.
Glioblastoma, also known as grade IV glioma, is the most aggressive primary brain tumor
in humans.
Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have discovered a peripheral biomarker
in human blood serum that can be used to detect the presence and progress of
glioblastoma brain tumors before and after treatment.
Our group established that pediatric
Glioblastoma Multiforme (GBM), which is one of the deadliest cancers
in humans, are molecularly and genetically distinct from adult GBM.
Therapeutic efficacy of aldoxorubicin
in an intracranial xenograft mouse model of
human glioblastoma.
These results could pave the way for the use of progesterone against
glioblastoma in a
human clinical trial, perhaps
in combination with standard - of - care therapeutic agents such as temozolomide.
Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red)
in glioblastoma stem cells isolated from a primary
human glioblastoma with fused FGFR - TACC genes.
In another study, 11 human cancer cell lines (carcinomas and glioblastomas) were exposed to ascorbic acid in which 55 % of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubatio
In another study, 11
human cancer cell lines (carcinomas and
glioblastomas) were exposed to ascorbic acid
in which 55 % of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubatio
in which 55 % of the cell lines were more susceptible (EC50 ≤ 20 mmol / L) and 45 % were more resistant (EC50 > 20 mmol / L) to incubation.
Calorie restriction has been used effectively to treat malignant
glioblastoma multiforme
in mice, which shares many characteristics with
human glioblastoma multiforme, the most aggressive and invasive primary
human brain cancer [3].
A new five - year canine cancer research project, led by Dr. Liz Pluhar, may improve survival rates
in dogs and give researchers more insight into
glioblastoma to apply to
human trials.