The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested
in macromolecular structure and function.
Proteins: Concepts in Biochemistry teaches the biochemical concepts underlying protein structure, evolution, stability, folding, and enzyme kinetics, and explains how interactions
in macromolecular structures determine protein function.
Martin Friedlander, M.D., Ph.D., is a professor in the Department of Cell Biology and the Graduate Program
in Macromolecular and Cellular Structure and Chemistry at The Scripps Research Institute.
Epps, who is the Thomas and Kipp Gutshall Professor of Chemical and Biomolecular Engineering and professor of Materials Science and Engineering at UD, and two of his graduate students, Melody Morris and Thomas Gartner, recently published an article highlighting this work
in Macromolecular Chemistry and Physics.
Not only did he lift three trophies with Roma's Primavera squad, but he's also a member of the Department of Biochemistry at the University of Cambridge specializing
in macromolecular mechanisms of genome duplication and stability.
Not exact matches
Now Monod shows that the machinery by which the cell (Or at least the non-primitive cell, which is the only one we know) translates the codes «consists of at least fifty
macromolecular components which are themselves coded
in DNA.»
A
macromolecular fraction from mouse salivary glands markedly enhances growth of mesenchymal tissues
in vitro.
Therefore, before publication, large data sets (including microarray data, protein or DNA sequences, atomic coordinates or electron microscopy maps for molecular and
macromolecular structures, and climate data) must be deposited
in an approved database and an accession number or a specific access address must be included
in the published paper.
«The specific
macromolecular complex investigated
in this study has therapeutic implications not only for addiction, but also for Parkinson's disease and schizophrenia,» said Dr. Sergi Ferré, who led the team of scientists.
Unlike the particles
in a coffee drop, the liquid crystal drop they studied was a solution of Sunset Yellow molecules that spontaneously combine to form rod - like
macromolecular assemblies, similar to how rod - like molecules order to form the liquid crystals used
in LCDs.
The pair are corresponding authors on a paper appearing online on Feb 2
in the journal Small titled «Precise Manipulation and Patterning of Protein Crystals for
Macromolecular Crystallography Using Surface Acoustic Waves.»
Neela Yennawar, director of the Huck Institute's
Macromolecular X-ray Facility at Penn State and a co-author on the paper
in Small, said «Crystallographers are pushing the boundary of biological samples being studied and moving towards more difficult targets of higher molecular weight and complexity.
Now Helbich,
in collaboration with Professor Bernhard Rieger, Chair of
Macromolecular Chemistry, has for the first time successfully embedded the silicon nanosheets into a polymer, protecting them from decay.
Enzymes are
macromolecular biological catalysists that lead most of chemical reactions
in living organisms.
As researchers gradually gain more insight into the genome's hierarchy of structures, they will get closer to figuring out how this
macromolecular wonder works
in all of its vastness and mechanistic detail.
The work is based
in the Rosetta
macromolecular modeling package developed by Baker and his colleagues.
«If this is to be any serious use, I suspect it will be
in collaboration with existing super-resolution techniques, on small
macromolecular complexes, to push the boundaries a bit further, rather than looking at whole cells.»
«The significance of this study is that we're going to see more comparative studies of
macromolecular concentrations — such as differences
in proteins and lipids — which reveal things that can't be read out directly» from the genome, says Todd Preuss, a neuroscientist at Emory University who specializes
in the evolution of the human brain and who was not involved
in the study.
Single - particle cryoelectron microscopy (cryoEM) is now able to provide structures of
macromolecular assemblies to resolutions approaching 3 Å, sufficient to allow the polypeptide chain fold to be traced
in a number of cases.
CCP4 got its start
in the 1970s when a number of new
macromolecular crystallography groups spawned from the pioneering labs at the Laboratory of Molecular Biology at Cambridge and the biophysics department at Oxford.
A partial list would include the Patterson function, isomorphous replacement, and anomalous scattering, which enabled the determination of organic structures; direct (i.e., purely computational) methods of phase determination, which enabled small - molecule crystallography to be almost totally automated; synchrotron radiation and area detectors, which together made it possible to collect data on
macromolecular structures
in hours instead of months; and automatic interpretation of electron density maps.
The structural analysis guides further mutagenesis and biochemical experiments
in both reconstituted systems
in vitro and
in primary cells, to finely analyze the mechanisms that mediate
macromolecular function, or lead to a pathological dysfunction.
Access to third generation synchrotron beamlines for
macromolecular crystallography
In collaboration with the ESRF, we provide access to seven
macromolecular crystallography beamlines at the ESRF and an EU funded User Programme exists to support this access.
He served as a steering committee member of the EPSRC Innovative Manufacturing Research Center for Bioprocessing and Center for Innovative Manufacturing
in Emergent
Macromolecular Therapies, both at University College London.
Optical imaging and spectroscopy, advanced optical imaging techniques
in particular super-resolution fluorescence microscopy, optical physics, nanotechnology, single - molecule biophysics and
macromolecular biochemistry, single - molecule imaging, gene expression, computational modeling, single - molecule (force) spectroscopy, biomolecular engineering, nucleic acid nanotechnology
As an introduction to electron microscopy I can highly recommend Transmission Electron Microscopy by Ludwig Reimer and Helmut Kohl and Three - Dimensional Electron Microscopy of
Macromolecular Assemblies: Visualization of Biological Molecules
in Their Native State by Joachim Frank.
The research of the department focuses on the development of cryo - electron tomography which is widely seen now as a method of unique potential for visualizing
macromolecular complexes
in their functional cellular context.
A lung - on - a-chip created
in the lab of Shuichi Takayama, professor of biomedical engineering and
macromolecular science and engineering at the University of Michigan, for example, uses fluid mechanics to re-create the crackling stethoscope sounds associated with certain diseases of the lung.
Dr. Susannah Burrows, atmospheric researcher at Pacific Northwest National Laboratory, was quoted
in the IOP community website, environmentalresearchweb for her recent co-authored paper, «Prospects for Simulating
Macromolecular Surfactant Chemistry at the Ocean - Atmosphere Boundary» published
in Environmental Research Letters.
Increased free radical induced oxidative stress plays a pivotal role
in pathogenesis of many diseases including obesity, T2D and AP [7, 39 - 43] leading to
macromolecular damage (DNA, protein and lipids), inflammation, ER stress and necrosis of acinar cells [44].
The Synchrotron Crystallography team works
in close collaboration with the Structural Biology Group of the European Synchrotron Radiation Facility (ESRF)
in the design, construction and operation of
macromolecular crystallography (MX) and biological small angle X-ray scattering (bioSAXS) beamlines.
Vertrees was first introduced to PyMOL
in 2005 as a graduate student
in biophysics at the University of Texas Medical Branch at Galveston during a class on
macromolecular modeling.
Tanja Weil received her Ph.D.
in organic and
macromolecular chemistry from the University of Mainz (2002) for her work with Prof. K. Müllen at the Max - Planck - Institute for Polymer Resaerch.
With performances multiplied by 100
in terms of brilliance and coherence, this new source of synchrotron radiation will offer unprecedented tools for the exploration of matter and for the understanding of life at the
macromolecular level.
«Ultimately, we intend to make it so it is replaced by natural bone over time,» said Russell Stewart, associate professor of bioengineering and senior author of the synthetic glue study, which will be published
in the journal
Macromolecular Biosciences.
Marcio Loos is a post-doctoral researcher
in the Department of
Macromolecular Science and Engineering at Case Western Reserve University and worked with investigators from Bayer MaterialScience
in Pittsburgh, and Molded Fiber Glass Co.
in Ashtabula, Ohio, to try and find the best material for turbine blades.