Sentences with phrase «in mycobacterium»

The Department of Microbiology of the Yonsei University College of Medicine, is investigating on identification and functional study of virulence determinants in Mycobacterium tuberculosis by comparative genome - based analysis.

A comprehensive map of genome - wide gene regulation in Mycobacterium tuberculosis.

Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis.

The Otago researchers» studies on hydrogen fermentation in mycobacteria have been performed in collaboration with Professor William Jacobs Jr., a world - leading bacterial geneticist at the Albert Einstein College of Medicine in New York, who is known as the «TB terminator».

«We hope to refine these multivariable descriptions so that we can anticipate the cyclic changes to drug susceptibility in mycobacteria, and eventually use them to shorten the long and difficult treatment course for tuberculosis.»

Not exact matches

What it does: This bacteria is most notorious for causing severe illnesses such as tuberculosis, leprosy, and Hansen's disease, though most species of mycobacteria in nature are benign in humans, unless in cases of those who have weakened immune systems.

The company's lead product candidate is amikacin liposome inhalation suspension, which is in late - state development for adult patients with treatment refractory nontuberculous mycobacteria lung disease caused by mycobacterium avium complex.

David Lomasney initially brought the issue to a town board meeting in May, saying his then - two - year old son was recovering from surgery to remove a growth from his neck caused by mycobacterium avian infection, adding that it may have happened because his neighbors have chickens which used to move freely onto his property.

Leprosy, a devastating chronic disease caused by the bacterial pathogen Mycobacterium leprae, was prevalent in Europe until the late Middle Ages.

«It performed so well in the preclinical model, we determined that to boost its effects further was essentially impossible,» said Orme, also a co-founder of CSU's Mycobacteria Research Laboratories.

Han's team, in collaboration with Francisco Silva, an evolutionary geneticist from Spain, analyzed 20 genes of Mycobacterium lepromatosis and compared them with those of Mycobacterium leprae.

All worldwide Mycobacterium leprae strains analyzed so far, more than 400 in total, have been found to have essentially identical genomes, or be clonal.

The study, «The efficacy of the BCG vaccine against newly emerging clinical strains of Mycobacterium tuberculosis,» was published in the journal PLOS One in September.

Recombinant vaccines rely on one or more antigens — proteins associated with the target bacterium — that boost an immune response; in this case Mycobacterium tuberculosis, which causes TB.

Work led by MD Anderson pathologist Xiang - Yang Han, M.D., Ph.D., a professor in laboratory medicine, resulted in the discovery in 2008 of a new leprosy - causing species, called Mycobacterium lepromatosis.

Taking this «hygiene hypothesis» in an even more surprising direction, recent studies indicate that treatment with a specific soil bacterium, Mycobacterium vaccae, may be able to alleviate depression.

In 1873 that hypothesis was bolstered when a Norwegian doctor named Armauer Hansen discovered Mycobacterium leprae, the bacterium that causes the disease.

Despite being curable with multidrug therapy, leprosy still persists in many developing countries, with more than 200,000 new cases every year and increasing drug - resistant strains of the leprosy bacterium, Mycobacterium leprae, emerging.

As more mycobacterial genomes are sequenced, a picture is emerging that Distributive Conjugal Transfer may have shuffled the genomes of environmental mycobacteria to create a strain that was particularly well suited for growth in mammalian lungs.

Wild boar and red deer are key hosts of bovine tuberculosis — a chronic, infectious disease mainly caused by Mycobacterium bovis — in southern Europe, with the incidence of TB in these animals particularly high in certain areas of Spain.

In the study, the investigators treated Mycobacterium tuberculosis - infected mice with anti-tuberculosis drugs or vitamin C alone, or the drugs and vitamin C together.

So I was pretty excited by a lovely little pearl in PLoS Pathogens last month discussing mycobacteriophages; the viruses that specifically attack mycobacteria.

The researchers found that adding verapamil augmented the potency of bedaquiline and accelerated its ability to clear mycobacteria in mice.

One key paper, published in the Journal of General Microbiology several months before the patent was filed, describes a way of distinguishing species of mycobacterium.

These cells quench the function of T - cells and other immune cells, which participate in the immune response against the mycobacteria.

«What we saw in mice lacking STIM1 — whose T - cells can not generate calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.

Using a combination of cell - based and mouse models, the researchers showed that the recently - evolved mycobacteria were more virulent, likely to cause more serious disease in patients.

Now, in a novel twist, researchers have found a way to recruit help from none other than Mycobacterium tuberculosis itself to make the deadly pathogen susceptible to an existing TB drug that it has learned to dodge.

They infect cattle by contaminating feeding areas and even the air with Mycobacterium bovis, the bacteria that causes TB both in badgers and in cows.

Introduction of the vaccine, which contains a killed mycobacterium — a distant relative of the leprosy organism — began early last month in the state of Gujarat in western India, and it will soon be deployed in Bihar state, in the east.

Now, by sequencing the whole genomes of over 1,000 isolates of mycobacteria from 517 individuals attending CF specialist centres in Europe, the US and Australia, researchers have demonstrated that the majority of CF patients have acquired transmissible forms of M. abscessus that have spread globally.

Now, in a novel twist, researchers have found a way to recruit help from none other than Mycobacterium tuberculosis itself to make the deadly pathogen susceptible to an existing tuberculosis (TB) drug that it has learned to dodge.

The most common of these genes were similar to those found in the genera Bradyrhizobium, Solibacter, Sphingomonas, Burkholderia, Mycobacterium, Mesorhizobium, and Pseudomonas.

Red squirrels in Scotland, Ireland and the Isle of Wight were found to be carrying Mycobacterium lepromatosis, a bacterial strain that is closely related to a virulent form of human leprosy endemic in Mexico and the Caribbean.

Animals on Brownsea Island in Poole harbour carried a different type, Mycobacterium leprae, which is known to have affected people living in southern England over 700 years ago.

Then Mays, along with molecular biologist G. Michael Taylor of Imperial College in London, confirmed that the scars were signs of TB by identifying traces of gene sequences from Mycobacterium tuberculosis in the 2300 - year - old remains.

In the Kafue area, a high incidence of Mycobacterium bovis in both cattle and the Kafue lechwe antilope has been detecteIn the Kafue area, a high incidence of Mycobacterium bovis in both cattle and the Kafue lechwe antilope has been detectein both cattle and the Kafue lechwe antilope has been detected.

Mycobacterium tuberculosis, the organism that causes tuberculosis in humans, also afflicts Asian (and occasionally other) elephants.

Mycobacterium tuberculosis, which is the main cause of human tuberculosis, has also been detected in cattle in this region.

The goal is to find new ways to tackle the disease, which requires a thorough understanding of how the bacterium, known as Mycobacterium tuberculosis, behaves once it takes hold of the macrophages in our lungs.

One previous study found that 17.8 % of drug resistant TB among humans in Morocco was due to M. bovis rather than the classic Mycobacterium tuberculosis.

Mycobacterium ulcerans, the bacteria that cause Buruli skin lesions and bone deformities, can thrive in a wide range of wild creatures, especially tiny insects grazing on freshwater algae, says Aaron Morris, now at Imperial College London.

TB, which is caused by the bacterium Mycobacterium tuberculosis, exploded in Russia and other former Soviet nations in the early 1990s, after the collapse of the Soviet Union and its health system.

Nontuberculous mycobacteria (NTM) include more than 150 types of bacteria, found in water and soil, that can infect the lungs when inhaled.

Both the seals and the trainer were infected with the same strain of Mycobacterium bovis, which causes tuberculosis in animals ranging from buffalo to badgers.

Krause found that the bacteria in the skeletons were closely related to a TB strain called Mycobacterium pinnipedii, which infects sea lions and seals, and not to the strains infecting humans today.

In collaboration with researchers in the US and Germany, Otago microbiologists have teased out the mechanisms by which the aerobic soil microbe Mycobacterium smegmatis is able to persist for extreme lengths of time in the absence, or near - absence, of oxygeIn collaboration with researchers in the US and Germany, Otago microbiologists have teased out the mechanisms by which the aerobic soil microbe Mycobacterium smegmatis is able to persist for extreme lengths of time in the absence, or near - absence, of oxygein the US and Germany, Otago microbiologists have teased out the mechanisms by which the aerobic soil microbe Mycobacterium smegmatis is able to persist for extreme lengths of time in the absence, or near - absence, of oxygein the absence, or near - absence, of oxygen.

In experiments using Mtb, the scientists found that mycobacteria without lamA formed far less diverse bacteria with more uniform susceptibility to antibiotics.

Their findings, published in the journal PNAS, show that hydrogen is a key factor that enables mycobacteria to survive oxygen - limitation over long periods.

The TB bacterium Mycobacterium tuberculosis (Mtb) is estimated to be present in up to a third of the world's population, although active TB only develops in around one in 10 cases.