Sentences with phrase «in water maze»

Dissociation between Performances in Water Maze and Spontaneous Alternation in BALB / C versus A / J Mice

Streptozotocin - diabetic rats express deficits in water maze learning and hippocampal synaptic plasticity.

When administered intraperitoneally to PDGF - AS mice, this conjugate reduced AS neuropathology, neuronal loss, astrogliosis, and behavioral deficits in the water maze.

J147 and J147 + donepezil rescued the deficit in spatial navigational memory caused by scopolamine in the water maze but donepezil alone failed to rescue the deficit (Figure 4B).

In the water maze test, the mice needed to elevate themselves onto a platform in a specific location to get out of the water.

At 14 months, however, the J20 / caspase -2 null mice did significantly better in the water maze test than the J20 mice and similarly to the normal mice.

Afterward, he compares the mental abilities of injured and uninjured rats by testing their reactions to novel and familiar objects (top) and by placing them in a water maze (bottom).

The mice administered MW108 found the resting platform in the water maze as quickly as a control group of mice.

The mutant mice had difficulty learning and remembering the location of a hidden platform in a water maze, which ordinary mice accomplish with ease.

First she deprived juveniles of vision in one eye so that the corresponding brain cells failed to make connections; once the mice reached maturity, they were put in a water maze that required them to recognize a pattern of fine lines to find a floating platform.

For example, after receiving THC, young mice took longer to learn where a safe platform was hidden in a water maze, and they had a harder time recognizing another mouse to which they had previously been exposed.

Not exact matches

Young adventurers love to frolic around cascading fountains and crawl through a mix of water - spraying mazes, especially in hot weather.

«They're in a germ - free facility,» she says apologetically, glancing away from a video in which a tiny champion powers through a water maze.

Subsequent analyses of the brains of these animals revealed that the drug reduced the plaques and tangles in the hippocampus, which is known to play a key role in learning the water maze, but not in the amygdala, which figures importantly in the dark chamber test.

Mice bred to have a malfunctioning form of CREB, Silva's study demonstrated, did not remember from one day to the next that they had already been taught to navigate a water maze or that they had previously been placed in a special cage where they received a mild electric shock.

When the pups get older, they will learn to paddle through water mazes or bury black marbles in their bedding, giving researchers insight into how their memory and behavior compare with that of typical mice.

The mice had to swim to a platform in a memory task called a Morris Water Maze.

The research was done with laboratory mice that consumed different diets and then faced a variety of tests, such as water maze testing, to monitor changes in their mental and physical function, and associated impacts on various types of bacteria.

Indeed, when mice lacking the gene for making IL - 4 take the water maze test, they do badly, perhaps because their T cells lack a critical signal involved in fast learning.

In a paper appearing online this week in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal micIn a paper appearing online this week in the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal micin the early edition of the journal Proceedings of the National Academy of Sciences, University of California, Berkeley, scientists who invented the photoswitch therapy and veterinary colleagues at the School of Veterinary Medicine of the University of Pennsylvania (UPenn) report that blind mice regained the ability to navigate a water maze as well as normal mice.

Hanczyc and his colleagues from Prague have shown that small droplets of alcohol in water can move through complex mazes.

An experimental chemical that blocked its action created temporary geniuses: Mice on it were whizzes in the Morris water maze.

The scientists confirmed that these mice have learning problems by testing them in a Morris water maze, a common lab test of animal learning and memory.

«The Honeycomb Maze replicates all the advantages of the justly - famous Morris Water Maze in that it forces the animal to approach a hidden goal from different directions, ruling out non-hippocampal-dependent strategies.

A powerful new tool for the study of spatial memory was today described in Nature as a significant improvement over the current gold standard, the Morris Water Maze.

Mice were administered the Morris water maze test in an opaque pool with a submerged platform, and humans were administered a virtual version in a circular field with a buried treasure using a 30 - in.

Here, we examined the extent to which performance in the Morris water maze — the most frequently used behavioral assay of spatial learning and memory in rodents — translates to humans.

We want you to have software that fits the bill for all of these, from straight - forward protocols such as open field or Morris water maze testing, to high - throughput testing, such as zebrafish larvae activity monitoring in 96 - well plates.

A High Fructose Diet Does Not Affect Amphetamine Self - Administration or Spatial Water Maze Learning and Memory in Female Rats.

Results from this two - day water maze show that AD mice take considerably longer to find the hidden platform on Day 2 than AD mice treated with J147 for three months (Figure 1A), demonstrating that J147 significantly improved the spatial navigational memory in aged, transgenic AD mice.

They have spatial learning and memory defects as assessed in the Morris water maze and the radial arm maze, show developmental delay in sensorimotor milestones, and exhibit locomotor hyperactivity, lack of behavioral inhibition, and stereotypic behavior.

in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test

Using a genetic approach to increase spine turnover, they show that higher pre-learning spine turnover positively correlates with learning and memory performance in contextual fear conditioning and Morris water maze.

(B) Treatment with scopolamine significantly increased the time taken to find the platform compared to saline controls in the two day water maze.

The PD model animals did prove to exhibit substantial water maze deficits, both in time to locate the hidden platform and in time spent in the target quadrant on the probe test.

In contrast, the current virtual version included the same design and metrics as the water maze.

Previous adaptations of the Morris water maze for humans varied significantly from the original in their design and performance measures.

Water maze learning and hippocampal synaptic plasticity in streptozotocin - diabetic rats: effects of insulin treatment.

This video will summarize principles of Morris Water Maze testing review procedures for setting up and running the test and highlight some ways that this and other water tests are used in lab stuWater Maze testing review procedures for setting up and running the test and highlight some ways that this and other water tests are used in lab stuwater tests are used in lab studies.

Since water is very effective in encouraging rodents to explore a maze, it's no surprise that many water - based maze variants exist.

The Morris water maze is a valuable tool to study learning and memory in rodents.

We here studied, in intact young and aged adult mice, drinking - water (1μM) estradiol effects on both retention and organizational components of hippocampus - dependent memory, using a radial - maze task of everyday - like memory.

The difference in results obtained in the two tasks designed to test reference memory (cross maze and water maze) indicated that the disturbance depended on task difficulty rather than on a particular memory component.

Each animal received 6 daily training trials in the hidden version of the Morris water maze (in blocks of 2 consecutive trials) for 5 consecutive days.

(C) Quadrant occupancy and (D) target crossing measures during the probe trial given after completion of training in the Morris water maze.

The Morris water maze has been extensively used in mice and rats, but unfortunately people are not necessarily using it correctly or analyzing the data in the right way.

First constructed in the 1960s, the state's maze of tunnels and dams carry melted snowfall and freshwater from Northern California, where two - thirds of water falls, down to the drier southern part of the state.

The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze.

At this latter time point, all groups presented similar performance in cognitive tests (Morris water maze and inhibitory avoidance).

That means I need to find ways to increase BDNF more than in someone with the normal gene in order to preserve my cognitive function, memory, and emotional regulation.8 Mu, J.S., et al. «Deprivation of Endogenous Brain - Derived Neurotrophic Factor Results in Impairment of Spatial Learning and Memory in Adult... continue 9Cirulli, F., et al. «Intrahippocampal Administration of BDNF in Adult Rats Affects Short - term Behavioral Plasticity in the Morris Water Maze and... continue