The forward has a decent record at international level, with 14 strikes in his 47 appearances, although only three of his goals have
come in competitive fixtures.
The former Barcelona and Malaga forward is yet to find a goal
in a competitive fixture for the Toffees, with the player having only been able to register one assist so far in 11 appearances.
Diego Simeone was forced to start Axel Werner in goal for the first
time in a competitive fixture after Jan Oblak pulled out with a groin injury and Diego Godín was also unable to play due to gastroenteritis.
But with Euro 2016 qualification already close to being secured after four successive victories, surely now is the time to experiment with some different
options in competitive fixtures.
The first leg will take place at Guardiola's old stomping ground at the Camp Nou and he will manage against his old
club in a competitive fixture for the very first time in his career.
While Arsenal have made a better start to this season and are playing better football, Arsene Wenger has failed to ever beat one of Mourinho's
sides in a competitive fixture.
It was a result that extended the Dutchman's 100 %
record in competitive fixtures against the Reds to four games and saw his goal - scoring captain claim the club's 100th goal at Anfield.
Coutinho had developed such a reputation while making his way through the Vasco youth ranks that it was seen in no way as a gamble, despite his age and the fact they would have to wait 24 months before he could pull on the blue and
black in a competitive fixture.
Speaking after Friday's draw paired Atletico with Arsenal for the clubs» first
meeting in a competitive fixture, the former Atletico player told BeIN Sports that he was expecting a difficult tie.
Tottenham Hotspur will meet Juventus for the first time
in a competitive fixture when they travel to Turin for the Champions League round of 16 first - leg.
Wales are heavy under dogs going into the match but they will take heart from the fact they have already beaten
Belgium in competitive fixtures last year in the qualifying round.
Tuesday night wasn't the Welshman's best performance but he's two from three
in competitive fixtures this season and remains the most likely to net of anyone behind the strikers.