Not exact matches
Instead of working
in some modern office tower for a world - class company, the
pair spent their summer inside a converted brick
duplex in Oakland, California.
Klenow fragment of Escherichia coli DNA polymerase I, which was cocrystallized with
duplex DNA, positioned 11 base
pairs of DNA
in a groove that lies at right angles to the cleft that contains the polymerase active site and is adjacent to the 3» to 5» exonuclease domain.
The contribution made by individual functional groups of the G.U
pair in the context of the Tetrahymena ribozyme was examined by replacement of the G.U
pair with synthetic base
pairs that maintain a wobble configuration, but that systematically alter functional groups
in the major and minor grooves of the
duplex.