Sentences with phrase «in a larger cohort»

The team is now applying for grant funding to expand their study in a larger cohort across multiple sites.

Yet a pilot study of 200, 500, or 1,000 samples may be feasible, and may uncover results that can be replicated in the larger cohort.

The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.

Methods In a large cohort study, the Avon Longitudinal Study of Parents and Children (n = 14541 pregnancies), we aimed to (i) investigate the relative influences of parental postnatal depression and marital conflict on child outcomes and to attempt to determine the pathway (s) of risk; (ii) investigate the impact of two types of antenatal stress (parental depression and marital conflict) on child outcomes; and (iii) determine the relative contributions of antenatal and postnatal risk.

First observed in B - cell lymphoma, recurrent mutations of epigenetic modifier genes have recently been identified in PTCL - NOS. 9 In the present study, we performed targeted sequencing of the main epigenetic modifier genes in a large cohort of Chinese PTCL - NOS patients.

Khachaturian says a proper test of Roses» findings — using Roses» methods in a larger cohort of patients — has not yet been done.

The new CNGB1 mutation in Phalenes and Papillons was discovered with six cases and 14 control dogs and confirmed in a larger cohort of dogs.

Surprisingly, we found the same signature in large cohorts of women without the BRCA1 mutation and it was able to predict breast cancer risk several years before diagnosis.»

A possible association between Ebstein anomaly with LVNC and mutations in MYH7 encoding ß - myosin heavy chain was tested in a large cohort of unrelated probands with Ebstein anomaly.

Saturday, Oct. 21, 9:45 - 10:45 a.m., Room 330A, South Building Platform Session: Advancing Drug Discovery by Genetic Analysis in Large Cohorts Moderator: Dana Crawford, Case Western Reserve University

Friday, Oct. 20, 5:30 - 5:50 p.m., South Hall B, South Building Featured Plenary Abstract: The contribution of rare variants, polygenic risk, and novel candidate genes to the hereditary risk of breast cancer in a large cohort of breast cancer families N. Li, Peter MacCallum Cancer Center, et al

CONCLUSIONS High total and animal protein intake was associated with a modest elevated risk of type 2 diabetes in a large cohort of European adults.

Primary pupils who took this year's key stage 2 SATs tests in small class sizes performed the same as their peers in larger cohorts, according to new government data.

Studies also suggest a potential role for selected probiotics in atopic dermatitis prevention, and future studies will need to standardize the probiotic strain as well as amount used in a larger cohort of pregnant women in order to better assess these effects.

«This is the first investigation into the link between sleep disturbance and dementia in a large cohort of older, mostly male veterans,» said Yaffe.

«We hope to design a program that draws from these findings and more research on mindfulness meditation is needed in a larger cohort of mothers,» added Golfenshtein.

By evaluating the molecular changes that occur in large cohorts of ovarian cancer patients, the researchers were able to identify several lncRNAs that are linked to the disease.

The aim of this new study was to determine whether 2D: 4D was associated with the risk of severe knee or hip OA requiring total joint replacement in a large cohort study.

«We found a significant relation between brown fat activity and miR - 92a that needs to be proven in larger cohorts,» said co-first author Joschka Johannes Buyel, a PhD student in Prof. Pfeifer's lab.

Now a team of UCLA researchers has shown for the first time in a large cohort of patients that electroconvulsive therapy (ECT), sometimes referred to as shock treatment, change certain areas of the brain that play a role in how people feel, learn and respond to positive and negative environmental factors.

Interestingly, two recent reports that have catalogued recurrent focal deletions in large cohorts of human tumors and cancer cell lines.

The present study was aimed at identifying genetic modifiers modulating AAO in a large cohort of Italian FTD patients.

Replication of these findings in a larger cohort is necessary, although it lies beyond the scope of this thesis.

We have investigated the prevalence of this mutation in large cohort of almost 1000 patients with AML (3).

More recently, GLP - 1 response was evaluated in a large cohort of subjects of both sexes, with different degrees of BMI and ranging from NGT to T2DM.

This study's objective is to evaluate the association between maternal influenza infection and vaccination during pregnancy and ASD risk in a large cohort of children born at Kaiser Permanente Northern California (KPNC).

The LEAP study, designed and conducted by the ITN with additional support from FARE and led by Professor Gideon Lack at Kings College London, is the first randomized trial to prevent food allergy in a large cohort of high - risk infants.

Prevalence of parietal cell antibodies in a large cohort of patients with autoimmune thyroiditis.

Examining the relationship between childhood health conditions and health service utilisation at school entry and subsequent academic performance in a large cohort of Australian children

There thus appears to be a deleterious effect of the heterozygous genotype on CU traits: however, as true heterozygous effects are rare and the numbers of minor homozygotes in the high CU group are small, replication is required in larger cohorts to determine whether this is a true effect.

In the large cohort study mentioned above, the most common allergy was peanut with a prevalence of 2.6 %, followed by milk at 2.2 %, egg at 1.8 %, shellfish at 1.5 % and soy at 0.7 %.

They noted that this is exploratory and hypothesis - generating, and the findings need to be confirmed in a larger cohort.

«miR - 92a seems to be a promising biomarker to test new drugs in the field of weight reduction or transition from white - to - brown fat in humans; this promising biomarker should be tested in larger cohorts» said Prof. Pfeifer.

In the first study (Klaassen et al., 2008) mutational analysis in a large cohort of 63 unrelated adult probands with LVNC and absence of other congenital heart anomalies was performed.

Primary pupils who took this year's key stage 2 SATs tests in small class sizes performed the same as their peers in larger cohorts, according to new government...

The close collaboration with the Assisted Reproduction Unit, performing about 1,500 ovarian stimulation cycles / year, offers the possibility to validate the results of preclinical studies in a large cohort of patients.

«In this large cohort study, planned home birth in a low - risk population was not associated with higher perinatal mortality rates or an increased risk of admission to a NICU compared to planned hospital birth after controlling for maternal characteristics.»

Similarly, in another large cohort, the rate of VBAC was higher among women undergoing induction of labor at 39 weeks compared with expectant management (73.8 % versus 61.3 %, P <.001)(104).

In conclusion, never or curtailed lactation was associated with an increased risk of incident maternal hypertension, compared with the recommended ≥ 6 months of exclusive or ≥ 12 months of total lactation per child, in a large cohort of parous women.