Sentences with phrase «in a mouse model of the disease»

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

Social behaviors can be assessed with computer vision in mouse models of disease in a home cage environment T. HANANIA, P. KABITZKE, M. MAZELLA, I. FILIPOV, V. ALEXANDROV, D. BRUNNER... Abstract / Posters

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.

Recently research published in Cancer Discovery showed that changing the schedules of drug administration can improve outcomes leading to more complete responses in mouse models of the disease.

Blocking this inflammation after radiation therapy brought a significant improvement in survival in a mouse model of the disease.

Now an animal study led by Massachusetts General Hospital (MGH) investigators shows that even low levels of the Alzheimer's - associated APOE4 protein can increase the number and density of amyloid beta (A-beta) brain plaques, characteristic neuronal damage, and the amount of toxic soluble A-beta within the brain in mouse models of the disease.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

An international research team led by biochemists at The University of Texas Health Science Center at Houston (UTHealth) reduced the sickling of red blood cells in a mouse model of the disease.

Blocking this process with a small - molecule drug prevented the characteristic brain plaques and memory loss in a mouse model of the disease.

In 2005, a group led by Stephen Young, a cardiologist at the University of California, Los Angeles, showed that a class of drugs called farnesyltransferase inhibitors (FTIs) seemed to normalize cells with progeria, and in 2006 his team reported similar success in a mouse model of the disease.

By depriving the cancer cells of the amino acid cystine, the researchers were able to trigger a form of cell death called necrosis in mouse models of the disease.

Dr. Shoyele and colleagues showed that these components formed a spherical nanoparticle capable of properly finding the lung tumors and shrinking the tumors in mouse models of the disease.

These plaques are extracellular aggregations of a small protein called beta - amyloid that are prominent in diseased patients» brains, as well as in mouse models of the disease.

Jefferson College of Pharmacy researchers are developing a new treatment approach based on nanotechnology that was recently shown to be effective in mouse models of the disease.

«We showed that progranulin protects against AD in a mouse model of the disease.»

Most Alzheimer's research and drug development are done in mouse models of the disease.

Researchers find that in mouse models of the disease subcutaneous drug administration is sufficient to treat SMA...

In their report being published online in Nature Immunology, the researchers describe finding that a protein that regulates certain cells in the innate immune system — the body's first line of defense against infection — activates a molecular pathway known to be associated with lupus and that the protein's activity is required for the development of lupus symptoms in a mouse model of the disease.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the dystrophin defect in a mouse model of the disease and in human cells.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

In mouse models of the disease, tau tangles didn't form after the plaques appeared.

Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

MIT's Li - Huei Tsai, Ed Boyden, and their colleagues have shown that stimulating neurons to produce gamma waves at a frequency of 40 Hz reduces the occurrence and severity of several Alzheimer's - associated symptoms in a mouse model of the disease.