Moreover,
in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V
+S −), and a less differentiated cell type exhibiting a PrEn bias, but with
similar regenerative
capacities to the Nanog high population (V
+S
+).