Sentences with phrase «in a single gene»

Many are known to be caused by mutations in single genes, yet for the vast majority no treatments are available.

How kind you are could be affected by a change in a single gene.

Almost immediately such familial genome sequencing proved its value, uncovering mutations responsible for diseases caused by defects in a single gene.

I think that the cure for schizophrenia can be found in a single gene.

Three will hunt for mutations underlying rare inherited diseases caused by a glitch in a single gene.

In a stunning example of evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild.

Several types of severe combined immune deficiency in humans are thought to be caused by defects in single genes.

In contrast to Mendelian disorders (e.g., Huntington's disease, sickle cell anemia) in which variation in a single gene causes disease, common complex disorders, such as heart disease, diabetes, and most cancers, develop as a result of both genetic and environmental factors.

In 1971, Seymour Benzer and Ronald Konopka (both now deceased and ineligible for the Nobel Prize) found that fruit flies with mutations in a single gene called period had disrupted circadian rhythms, which caused the flies to move around at different times of day than normal.

This suggested that obesity in both obese and db mouse strains resulted from a mutation in a single gene in each case.

In 1986 my research group at the Rockefeller University and another led by Jeffrey Hall of Brandeis University and Michael Rosbash of the Howard Hughes Medical Institute at Brandeis found that the three mutant flies had three different alterations in a single gene named period, or per, which each of our teams had independently isolated two years earlier.

Since the 1980s, scientists at the State University of New York College of Environmental Science and Forestry (SUNY - ESF) have been developing a blight - resistant chestnut tree by engineering in a single gene from wheat.

Exome sequencing makes a lot of sense in certain Mendelian disorders, where (1) the pattern of inheritance, e.g. autosomal recessive, is known, and (2) the causative mutations occur in a single gene.

Fragile X, which is caused by a mutation in a single gene on the X chromosome, affects about 1 in 4,000 men and 1 in 6,000 women.

anemia and others result from a misplaced base letter in a single gene.

«Errors in single gene may protect against heart disease.»

In a study reported in March, a research team found that a variation in a single gene makes all the difference between ocean - going sticklebacks, which are covered in 35 bony plates to protect them from predators, and the many species of sleeker, minimally plated freshwater sticklebacks.

They also discovered that changes in a single gene encoding an important immune receptor lead to decreased inflammation only in Europeans.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

In a study of longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P - element insertional mutations in a single gene resulted in a near doubling of the average adult life - span without a decline in fertility or physical activity.

A mutation in a single gene produced extra sweat glands in Asian people's skin, perhaps to help them keep cool in the warm and humid climate

Humans and chimps each have somewhere between 20,000 and 30,000 genes, so there are likely to be nucleotide differences in every single gene.

Researchers once thought that the groups» distinct physiological and behavioral profiles stemmed from a variant in a single gene.

A small change in a single gene determines whether roundworms prefer to eat alone or with other worms.

The method potentially could help treat monogenic diseases, which result from modifications in a single gene occurring in all cells of the body.

This fatal disorder is caused by a hereditary defect in a single gene.

Cystic fibrosis is a rare inherited disease caused by mutations in a single gene called cystic fibrosis transmembrane conductance regulator (CFTR) and affects 1 in every 2500 newborns in the UK and over 90000 people worldwide.

But many researchers, including Keller and Ross, didn't think variations in a single gene could account for all the differences in size, fertility, odor, and aggression that separated the two ant groups.

Each strain contains an alteration in a single gene, the structure of which must be verified prior to breeding and phenotyping.

Could the solution be found in a single gene, asks Bob Holmes

Cystic fibrosis is a hereditary disease caused by mutations in a single gene called CFTR.

A rare condition that causes a person be born without fingerprints can now be explained by a mutation in a single gene, a new analysis suggests

SMA1 is a progressive, childhood, neuromuscular disease caused by a mutation in a single gene.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

Rockefeller's Jean - Laurent Casanova has identified mutations in a single gene that may explain what goes wrong in cases of encephalitis of the brain stem, the part of the brain that controls many basic functions including heart rate and breathing.

McCauley's interest is cystic fibrosis, a disease caused by mutations in a single gene, CFTR.

Cancer is rarely the result of a single mutation in a single gene.

Currently we are developing non-invasive tests for other conditions caused by mutations in a single gene, including cystic fibrosis, sickle cell anemia, and beta - thalassaemia.

«In the early years, cancer researchers focused on mutations in single genes, but then it became apparent that different mutations in a class of genes were driving the disease process,» he said.

In other words, type 2 diabetes could never make it into the Finnish Disease Heritage, where a change in a single gene is decisive.

Defects in single genes are known to cause illnesses such as sickle cell anemia, cystic fibrosis, and Huntington's disease.

In skin tumors the process can start with a change in a single gene, such as H - ras.

Newman, Phillips and their colleagues, including Rizwan Hamid, M.D., Ph.D., Joy Cogan, Ph.D., and James West, Ph.D., discovered that most of the cattle with high - altitude pulmonary hypertension had a double mutation in a single gene that expresses hypoxia inducible factor, HIF2alpha.

DMD originates with mutations in a single gene.

«This is an important finding that will help future researchers, and eventually physicians, to maximize the effectiveness of gene therapy for curtailing sensory deficits associated with USH3 syndrome and, perhaps, in other disorders linked to defects in single genes,» said Alagramam.

The work, which is described in Nature on August 2, 2017, is a collaboration between the Salk Institute, Oregon Health and Science University (OHSU) and Korea's Institute for Basic Science and could pave the way for improved in vitro fertilization (IVF) outcomes as well as eventual cures for some of the thousands of diseases caused by mutations in single genes.

At the same time, large genome - wide association studies (GWAS), which analyzed gene sequences from thousands of people, have found evidence suggesting that schizophrenia arises from the combined effects of many genes and not from a defect in any single gene.

To find other genes involved in tolerance, Heberlein and her team intoxicated 400 flies, each with a random mutation in a single gene.