Rather than ordinary spot - testing approaches, which look for unnatural ratios between biological
constituents in a single sample or for direct chemical evidence of known doping agents, the passport allows investigators to see the big picture — any deviations from the rider's test - established norm that might result from doping, even if the specific drug or tactic remains unknown.
SONAR can catalog a complete sample with precursor and fragment ion spectra from a data independent analysis (DIA)
experiment in a single sample injection, giving researchers quantitative and qualitative information about the proteins or metabolites.
Since each probe and probe set has different background characteristics (depending of cross hybridization, secondary structure, etc.), comparing expression values across different
probesets in a single sample is generally not recommended.
I was lucky to get
this in a single sample!!!