Sentences with phrase «in a subset of patients»

In addition to anti-tumor responses, immune checkpoint inhibitors have also been associated with long - term remission in a subset of patients, Gu said.

They can also induce responses against normal tissue antigens, leading the immune system to attack normal tissues and cause toxicity in a subset of patients.

The nomogram also performed well in subsets of patients at the extremes of weight and renal function (Table 3).

Zytiga's approval was based on trials showing a 38 % reduction in the risk of death in this subset of patients, an improvement that's clearly influencing doctor's use of the drug.

Cancer immunotherapy can produce durable clinical responses, but only in a subset of patients.

After a median follow - up of 22 months, the team found that the drugs were safe and shrank tumors in a subset of patients, with an overall response rate of 27 percent, which included complete responses in two patients and partial responses in four patients.

This, in turn, amplifies the effectiveness of fulvestrant, a drug commonly used in this subset of patients.

In the emergency department, «knowledge of the high - risk injuries in this subset of patients can help the trauma team to prioritize patient evaluations, which is especially important in complicated cases involving multiple injuries.»

The study was not powered to detect this improvement, but Kelbaek said he and his team would now look carefully for possible «hypothesis - generating» findings in subsets of patients — both those who might have benefitted from the deferred - treatment strategy and, equally important, those in whom this strategy might have worsened their condition.

«It is difficult to pinpoint the cause of bone loss in this subset of patients,» said allergist John Oppenheimer, MD, Annals associate editor and ACAAI fellow.

Professor Dive added: «We propose that this drug will be most useful in this subset of patients who have elevated MCT1 levels and need more effective treatments.

«We found that intensive doses of statins carry the potential for clearing up the lipid debris that can lead to vision impairment in a subset of patients with macular degeneration,» said Joan W. Miller, M.D., the Henry Willard Williams Professor and Chair of Ophthalmology at Harvard Medical School and Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital.

Dysregulated expression of CXCR4 / CXCL12 in subsets of patients with systemic lupus erythematosus.

Targeted drugs and combination therapies can drive cancer into remission, as they achieve optimal results in subsets of patients.

MYH7 mutations were predominantly found in Ebstein anomaly associated with LVNC and may warrant genetic testing and family evaluation in this subset of patients.

A growing number of studies also suggest that HHV - 6 may play a role in a subset of patients with chronic conditions.

The cytokines interleukin - 2 (IL - 2) and interferon - alpha cause kidney cancers to shrink in approximately 10 % -20 % of patients, and provide durable remissions in a subset of these patients.

In addition, HER2 is expressed in many normal tissues, giving systemic HER2 - targeted antibody therapy the potential to cause toxicity in a subset of patients, including cardiac myopathy, congestive heart failure, and pulmonary toxicity [14], [15].

While the alert system did not improve outcomes, in a subset of patients it did increase interventions, including more renal consultations and dialysis.

Unfortunately, in a subset of patients, the current diagnostic workup may not lead to a firm diagnosis.