Sentences with phrase «in abnormal accumulations»

Share Pei fever can also lead to Amyloidosis, an enzyme deficiency results in abnormal accumulations of amyloid proteins, causing liver or kidney failure.

This defect impairs the breakdown of complex molecules resulting in abnormal accumulation of this macromolecules in the cells of the peripheral and central nervous system.

Anything that results in an abnormal accumulation of material in the ear canal often can not get out due to the canal pointing upward and thus inhibiting drainage.

Not exact matches

Aside from the feat of answering the longstanding question of how the lymph system arises, understanding how it forms and develops can provide important insights into disease, from metastasis to the abnormal accumulation of lymph fluids, particularly in the wake of surgery to remove cancerous tumors.

Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can lead to hepatitis, cirrhosis, and sometimes liver cancer.

They found LM22A - 4 reduces abnormal protein accumulation, delays nerve cell degeneration, and improves motor skills in the animals.

LM22A - 4 treatment reduced the accumulation of abnormal proteins in the striatum and cortex — brain regions affected in Huntington's disease.

Other approaches target the abnormal accumulation of the protein tau in neurofibrillary tangles.

It may also bring about advances in diagnosing diseases like Alzheimer's and multiple sclerosis, both of which involve abnormal iron accumulation in the brain.

Amyloid — an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease — starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined, reports a surprising new Northwestern Medicine study.

Amyloid — an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer's disease — starts accumulating inside neurons of people as young as 20, a much younger age than scientists ever imagined.

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

In the current study, Dr. Santambrogio and her colleagues looked for abnormal accumulations of proteins in the synovial fluid (which bathes the joints) and blood of patients with JIIn the current study, Dr. Santambrogio and her colleagues looked for abnormal accumulations of proteins in the synovial fluid (which bathes the joints) and blood of patients with JIin the synovial fluid (which bathes the joints) and blood of patients with JIA.

Both types of dementia (memory and language) can be caused by an accumulation of beta - amyloid, an abnormal toxic protein in the brain.

Several human neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's disease but also aging, are linked to an accumulation of abnormal and aggregated proteins in cells.

«Our results indicate that exercise may slow the progression of Parkinson's disease by turning on the protective gene DJ - 1 and thereby preventing abnormal protein accumulation in brain,» Freed said.

Lewy bodies (accumulation of abnormal alpha - synuclein A protein in the human brain that is associated with the development of Parkinson's.

Alzheimer's disease, the most common form of dementia, is characterized by the accumulation of plaques (composed of amyloid - beta protein) and fibrous tangles (composed of abnormal tau) in brain cells called neurons.

Figure 2: Abnormal accumulation of the FGFR - TACC fusion protein (red) in glioblastoma stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.

Crigler - Najjar Syndrome is a rare genetic liver disease (incidence around 1/1 000 000 births) associated with the abnormal accumulation of bilirubin — a yellow pigment produced by the liver — in all the body's tissues, particularly the brain tissues.

NAFLD is an imbalance between the uptake and removal of lipids in hepatocytes, which leads to abnormal triglyceride accumulation, or steatosis.

A group of disorders that includes both Alzheimer's and FTD, tauopathies are characterized by the abnormal accumulation of the protein Tau in neurons.

(3,18; cf. 19,20) Even in visceral fat, it has recently emerged that the obesity - driven rise in inflammation and insulin resistance is associated with an abnormal accumulation of senescent cells, albeit senescent endothelial cells rather than adipocytes.

However, it is widely accepted that a central event in AD pathogenesis is the abnormal accumulation of Aβ and its related toxins, either due to increased production or to deficits in clearance mechanisms [52, 53].

We report here that in vitro generated DS neural cells have abnormal metabolism of amyloid - β (Aβ) manifested by increased secretion and accumulation of Aβ granules of Aβ42 pathological isoform with upregulated expression of the APP gene.

We are particularly interested in how aging - related pathways, such as sirtuins, modulate the processes underlying the abnormal accumulation and microglial activation.

The relatively small number of such cells in a youthful tissue is so small as to be harmless, but after decades of accumulation, the number becomes large enough that their abnormal metabolic state begins to pose a threat to surrounding, healthy tissues.

Abnormal accumulation of aluminum has been found in the brains of people with Alzheimer's disease, and when aluminum is injected into the brains of laboratory animals, the animals develop a neurological disease similar to Alzheimer's.

Congestion, an abnormal accumulation of blood, in the lower extremities is no good thing.

Edema is an abnormal accumulation of fluid in a body part.

Bloat (dilation) is a condition of an abnormal accumulation of air, fluid, and / or foam in the stomach and can occur with or without the twisting (volvulus) of the stomach.

Since the major culprit in diabetes is the abnormal accumulation of glucose in the blood, a canine diabetic diet is centered on reducing the carbohydrate content of food.

Hepatic lipidosis: an abnormal accumulation of lipids in the liver which leads to liver failure.

Hydrocephalus: a condition where there is an abnormal accumulation of fluid in the ventricles of the brain.

Anasarca: a condition where neonatal puppies have an abnormal accumulation of fluids in their tissues.

This condition is caused by abnormal accumulation of air in the stomach.

This can lead to an abnormal accumulation of excessive copper in the liver known as copper storage hepatopathy, leading to hepatic dysfunction and scarring (cirrhosis).

According to PetPlace.com, nephrotic syndrome in dogs is a disorder that involves a combination of factors: protein in the dog's urine, a low blood protein level, high cholesterol and abnormal fluid accumulation known as edema anywhere in the pet's body.

The cause of microcytosis is not known; however, decreased serum iron concentration, normal to increased ferritin concentration, and accumulation of stainable iron in the liver suggest that microcytosis is associated with abnormal iron metabolism rather than absolute iron deficiency.

(2) To limit further liver damage by preventing accumulation of copper and free radicals (3) To support liver cell regeneration (4) To prevent or minimize possible complications, such as abnormal brain function caused by passage of toxic substances from the liver to the blood (called hepatic encephalopathy) and the buildup of fluid in your dog's abdomen (called ascites).

The iodine is taken up by the active (abnormal) thyroid tissue, but not by any other tissues, resulting in a selective local accumulation of radioactive material in the abnormal tissues.

Cough, exercise intolerance, dyspnea (difficulty breathing), abnormal lung sounds, hepatomegaly (enlargement of the liver), syncope (temporary loss of consciousness due to poor blood flow to the brain), ascites (fluid accumulation in the abdominal cavity), abnormal heart sounds, death

Patients with hydrocephalus have abnormal accumulation of cerebrospinal fluid (CSF) in the ventricles, or cavities, of the brain.

The exact mechanisms leading to the abnormal accumulation of air in respiratory tissues are not well understood.

Known as bloat, distended abdomen is an abnormal accumulation of fluid in the abdomen.

Foul breath because of the abnormal accumulation of nitrogenous wastes in the blood unable to be eliminated because of kidney failure

Edema is an abnormal accumulation of fluid in the cavities and intercellular spaces of the body.

Abnormal anatomy and placement of the liver, ascites (fluid accumulation in the abdomen) and shunt location not only confirms the condition, but can also help to differentiate between the two different types of dog liver shunts.

A surprising number of cats have problems with constipation (abnormal accumulation of feces and difficulty defecating), and similar but more serious conditions such as obstipation (complete obstruction of the colon by feces) and megacolon (damaged nerves and muscles in the colon causing an inability to defecate).