They found a significantly greater incidence of joint problems
in the ad libitum fed puppies.
Indeed, Weigle et al (37) showed that increasing the dietary protein content from 15 % to 30 % produced a sustained decrease
in ad libitum intakes.
Chickpeas may influence fatty acid and fiber intake
in an ad libitum diet, leading to small improvements in serum lipid profile and glycemic control.
(These experimental diets contained a higher percentage of fat than is typically observed
in an ad libitum LCD, and thus they were more characteristic of an ancestral Inuit diet or the ketogenic diet for epilepsy.)
Discussion: Previous studies showed an increase in orexigenic neurotransmitters production in IF, inducing hunger and hyperphagia
in the ad libitum feeding days.
It is concluded that application of the glycemic index in isolation to judge the role of white vegetables in the diet and, specifically in the case of potato as consumed
in ad libitum meals, has led to premature and possibly counterproductive dietary guidance.»
Covert manipulation of the ratio of medium - to long - chain triglycerides in isoenergetically dense diets: effect on food intake
in ad libitum feeding men.
The researchers concluded that five cups a week of beans, chickpeas, split peas and lentils
in an ad libitum diet (meaning subjects weren't told to change their diet in any other way), reduced risk factors of metabolic syndrome.
Conclusions: An increase in dietary protein from 15 % to 30 % of energy at a constant carbohydrate intake produces a sustained decrease
in ad libitum caloric intake that may be mediated by increased central nervous system leptin sensitivity and results in significant weight loss.
In conclusion, a 15 % increase in energy from dietary protein at constant carbohydrate intake produces a sustained decrease
in ad libitum caloric intake that may be mediated by increased CNS leptin sensitivity and results in clinically significant weight loss.
The lack of disease progression
in ad libitum models of acute alcohol exposure may actually be relevant to human exposure.
Not exact matches
Mice were housed at the University of Colorado Anschutz Medical Campus or at the German Institute of Human Nutrition
in ventilated cages on a 12 h / 12 h light / dark cycle and fed standard chow
ad libitum.
Acute ethanol as a 2nd «hit»: Here we employ a model
in which acute binge alcohol is administered
in addition to chronic
ad libitum exposure (variously called acute on chronic, Gao - binge, or NIAAA model).
While the benefits of calorie restriction (CR — reducing food provisions relative to
ad libitum, «free choice» consumption) for metabolic / aging - related disease prevention and longevity promotion are well documented
in multiple organisms, the molecular basis for these benefits is still debated... >> MORE
«Caloric restriction (60 % of
ad libitum intake) maintained only during the 2 - week experimental period did not affect collagen accumulation, but did result
in decreased levels of the difunctional crosslink dihydroxylysinonor - leucine (DHLNL)
in sponges implanted for 10 days.»
Besides the standard feeding regime, and drinking water
ad libitum via an automatic watering system, the animal followed an environmental enrichment program
in which, next to permanent and rotating non-food enrichment, an item of food - enrichment was daily offered to the macaque.
Macaques received food (monkey chow) and water
ad libitum, and standard enrichment (food supplements, manipulatable items
in cage, human interaction with caretakers, perches or swings).
Mice were caged
in groups of no more than five, fed mouse chow and given water
ad libitum, and provided huts, bedding and chewable items for enrichment.
All mice were housed
in our Association for Assessment and Accreditation of Laboratory Animal Care - accredited barrier facility on a 12 h light / dark cycle, and given
ad libitum access to food (NIH31 Diet, Harlan no. 7917) and water.
Mice were fed
ad libitum with a standard diet (Harland Ibérica) and maintained
in a temperature - and light - controlled room (22 — 24 °C, 14L: 10D).
Food and water were given
ad libitum and all procedures were carried out
in accordance with the UK Home Office regulations under the Animals (Scientific procedures) Act 1986.
Mice were raised on a 12 - h light / dark cycle, with food and water available
ad libitum and were housed
in groups of two to three per cage.
Rather than throwing ingredients
in a blender
ad libitum, measure ingredients beforehand
in accordance with what you'd reasonably eat if you sat down to a solid meal.
In a Pennsylvania State University study, people invited to eat high - volume, low - calorie foods
ad libitum ate less over the course of a day.
Compared to
ad libitum fed controls, rodents maintained on IER (100 % ER / alternate days) for periods of 12 to 24 weeks typically exhibit lower post-treatment levels of fasting glucose 14, 16, 17, 29 and insulin.16, 17, 29 Using this particular IER protocol, Jiang et al28 have also demonstrated an increase
in oral glucose tolerance and tissue insulin sensitivity (measured using a hyperinsulinemic - euglycemic clamp) after four weeks
in healthy rats.
One study has tested the efficacy of IER (100 % ER / alternate days)
in preventing the development of high - fat diet - induced insulin resistance (IR).54 In this study, rats received ad libitum access to either standard (control) or high - fat cho
in preventing the development of high - fat diet - induced insulin resistance (IR).54
In this study, rats received ad libitum access to either standard (control) or high - fat cho
In this study, rats received
ad libitum access to either standard (control) or high - fat chow.
Weigle, DS et al. 2005 A high - protein diet induces sustained reductions
in appetite,
ad -
libitum caloric intake, and body weight despite compensatory changes
in diurnal plasma leptin and ghrelin concentrations.
We found that RMR, the major component of total daily energy expenditure, did not increase with the high - protein diets and that overall weight loss during
ad libitum feeding was fully explained by the cumulative reduction
in caloric intake.
The role of low - fat diets
in body weight control: a meta - analysis of
ad libitum dietary intervention studies
Subjects
in both investigations served as their own controls and were studied under isocaloric intake and
ad libitum feeding conditions.
In recently published studies of ad libitum, low - carbohydrate diets, experimental and control subjects consumed diets in which neither fat content nor protein content were held constant between groups (5 — 7
In recently published studies of
ad libitum, low - carbohydrate diets, experimental and control subjects consumed diets
in which neither fat content nor protein content were held constant between groups (5 — 7
in which neither fat content nor protein content were held constant between groups (5 — 7).
This favorable change
in body composition was due to a sustained decrease
in appetite and
ad libitum caloric intake.
We studied the consequences of a 15 % increase
in energy from dietary protein
in 19 subjects under weight - stable conditions (isocaloric diets) during the first 4 wk of the protocol and during active weight loss (
ad libitum diet)
in the final 12 wk of the protocol.
David S Weigle, Patricia A Breen, Colleen C Matthys, Holly S Callahan, Kaatje E Meeuws, Verna R Burden, Jonathan Q Purnell; A high - protein diet induces sustained reductions
in appetite,
ad libitum caloric intake, and body weight despite compensatory changes
in diurnal plasma leptin and ghrelin concentrations, The American Journal of Clinical Nutrition, Volume 82, Issue 1, 1 July 2005, Pages 41 — 48, https://doi.org/10.1093/ajcn/82.1.41
The decrease
in insulin AUC to baseline values after 12 wk of the
ad libitum high - protein diet most likely reflects a decrease
in the stimulus for insulin secretion resulting from the overall decrease
in energy intake by this point
in the study.
In the only published long - term study designed specifically to compare the effects of
ad libitum diets of normal - and high - protein content, the fat content of the 2 diets was held constant (10).
Design: Appetite, caloric intake, body weight, and fat mass were measured
in 19 subjects placed sequentially on the following diets: a weight - maintaining diet (15 % protein, 35 % fat, and 50 % carbohydrate) for 2 wk, an isocaloric diet (30 % protein, 20 % fat, and 50 % carbohydrate) for 2 wk, and an
ad libitum diet (30 % protein, 20 % fat, and 50 % carbohydrate) for 12 wk.
Another strength of this study is that all diets were to be consumed
ad libitum - they could eat as much as they wanted, so it more closely reflected what would happen
in real life, outside the setting of a clinical study.
If one was to read the study by Smith et al. 2014 «Unrestricted Paleolithic Diet is Associated with Unfavorable Changes to Blood Lipids
in Healthy Subjects» There were zero controls whatsoever as all subjects all ate
Ad libitum (as much or as little as they wanted) within a «Paleo» framework supplements were also not restricted.
Even
in one week, we often see significant weight loss, even with
ad libitum eating and wine consumption.
Ad libitum food intake on a «cafeteria diet»
in Native American women: relations with body composition and 24 - h energy expenditure
Replacement of dietary fat by sucrose or starch: effects on 14 d
ad libitum energy intake, energy expenditure and body weight
in formerly obese and never - obese subjects.
Compared to rats fed
ad libitum, alternate day fasted rats showed protection of age - related changes
in dendritic spine number and morphology (20).
While alternate - day fasting leads to calorie restriction over a two - day period
in many rodent species,
in some strains of mice, the animals managed to compensate for the calorie deficit created on fast days by increasing their intake on feast days twofold and thus keeping the total calorie intake over a two day period at the same level as
in mice fed an
ad libitum diet (17).
Furthermore, when myocardial infarction was induced
in rats maintained on an alternate - day fasting diet, reduced infarction size, improved cardiac function, and increased survival was observed, compared to rats fed
ad libitum (24,33,43).
Furthermore,
in an animal model of Huntington's disease, prolonged survival, reduced disease - associated weight loss and improved motor function was observed
in animals on an alternate - day fasting diet compared to animals fed
ad libitum (49).
Anson et al. showed that mice on alternate - day fasting regimen who consume the same amount of food
in a 48 - hour period as mice fed
ad libitum, decreased glucose and insulin concentrations to a similar degree as did mice on daily calorie restriction despite maintained energy intake and body weight (17).
However, C57BL / 6 mice maintained on the same alternate - day fasting regimen consume similar food quantities
in a 48 - hour time period and maintain body weights similar to that of mice fed
ad libitum (17).
In 1935, McCay et al. were first to describe that calorie restriction — deliberately reducing calories without causing malnutrition — prolongs mean and maximal lifespan in rats compared with rats fed ad libitum (2
In 1935, McCay et al. were first to describe that calorie restriction — deliberately reducing calories without causing malnutrition — prolongs mean and maximal lifespan
in rats compared with rats fed ad libitum (2
in rats compared with rats fed
ad libitum (2).
Numerous subsequent studies have confirmed that a calorie restriction of 30 to 60 percent of
ad libitum intake increases the life span by similar amounts
in a range of organisms including yeast, roundworms and rodents, while simultaneously decreasing or delaying the occurrence of age related diseases such as numerous cancers (including lymphomas, breast and prostate cancers), hypertension, stroke, diabetes, nephropathy, autoimmune disorders and other risks factors for cardiovascular disease (3,4).