Sentences with phrase «in affinity maturation»

More specifically, rabbits have two antibodies in affinity maturation mechanisms: gene conversion and hypermutation, as opposed to mice where no gene conversion occurs.

Not exact matches

«Maturation of the proteasome core particle induces an affinity switch that controls regulatory particle association» was recently published in the scientific journal Nature Communications.

This difference in binding ability to the two immunogens suggests the R2 immunogen may have driven the earlier stages of affinity maturation of this lineage in llama 1, which resulted in clones that could also recognize 96ZM651.02 gp140 as the immune response progressed and the lineage developed breadth via mutations in the V gene region.

Remarkably, both lineages have incurred a three - residue deletion in CDR2 during maturation suggesting the immunogens imposed constraints which resulted in a similar structural solution to high affinity binding that was achieved by different underlying sequences.

In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.

We would like to see some evidence that EBI2 expression in DCs affects antibody production / GC formation / affinity maturation in a polyclonal response.