Sentences with phrase «in aggressive breast cancers»

The signatures of the breast stem cells in the fetus were stunningly similar to the stem - like cells found in aggressive breast cancers, including a significant fraction of a virulent cancer subtype known as «triple - negative.»

Not exact matches

The other, a former White House aide to President Obama, tested positive for the BRCA2 gene mutation that has led to breast cancer in her family for generations — and is taking aggressive steps to avoid the same fate.

My dear friend who died in less than 18 months from aggressive breast cancer was told by the vicar to apologise to the church committee about a minor matter or «consider her future as a member» (I helped her prepare her reply and told her that she couldn't say what she wanted to say, she was insistent but I was emphatic «it's not the content....

The woman asking this of her sister had been in an out of the hospital struggling with an aggressive breast cancer for three years.

He's proposing that New York state become home to the most aggressive breast cancer screening program in the country.

Toward that end, Cuomo's new budget proposal seeks $ 90 million to implement «the most aggressive, best breast cancer screening in this country.»

«We are undertaking the most aggressive action in the nation to expand access to breast cancer screenings, because early detection is the best possible treatment,» Cuomo said.

Under Governor Cuomo's leadership, the State has taken the most aggressive action in the nation to improve access to breast cancer screening.

Cuomo proposed New York spend $ 91 million to make New York the state with the most aggressive breast cancer screening program in the country.

I propose $ 90 million to make New York where we have the most aggressive breast cancer screening operation in this country.

Medical opinion also varies on how the kind of breast cancer Lee had, a noninvasive form called ductal carcinoma in situ, should be treated, but Lee is adamant about early mammograms and aggressive treatment.

She carried in her cells a dangerous genetic mutation and died when she was 28, after refusing surgery for her aggressive, inherited breast cancer.

«Our discovery of these mutations is a first step in developing a genetics - based system for classifying endometriosis so that clinicians can sort out which forms of the disorder may need more aggressive treatment and which may not,» says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the Department of Gynecology & Obstetrics at the Johns Hopkins University School of Medicine and co-director of the Breast and Ovarian Cancer Program at the Johns Hopkins Kimmel Cancer Center.

«Study in early stage breast cancer shows that even small tumors can be aggressive.»

«This study forms the basis for future research in patients with breast cancer and offers hope for targeted therapy for patients with aggressive triple - negative inflammatory breast cancer,» said lead researcher Mateusz Opyrchal, M.D., Ph.D., Assistant Professor of Oncology at RPCI.

«We discovered that the aggressive cancer cells that are spreading in colon, breast, and skin cancer contained a much higher portion of the protein PITPNC1, than the non-aggressive cancer cells,» says researcher Nils Halberg of the CELLNET Group at the Department of Biomedicine at UiB.

PARP inhibitors have shown efficacy for a small group of patients with breast cancer with inherited mutations in BRCA genes, but have failed in the more aggressive triple - negative disease.

A COMPOUND that slows the proliferation of triple - negative breast cancer cells in lab tests could lead to the first drugs to target this aggressive type of tumour.

Researchers in China have discovered that a metabolic enzyme called AKR1B1 drives an aggressive type of breast cancer.

Recent studies have shown an increase in women with breast cancer choosing this more aggressive surgery, called contralateral prophylactic mastectomy, which raises the question of potential overtreatment among these patients.

«By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future studies into whether beta - blockers could be a useful adjuvant therapy in the treatment of some aggressive breast cancers.»

The study, which will be published December 21 in the Journal of Cell Biology, suggests that the loss of these particular Numb proteins makes breast cancers more aggressive and resistant to chemotherapy, but points the way toward new therapeutic approaches that could improve patient outcome by preserving p53 levels.

In the study, the genetic targets were messenger RNA (mRNA) that code for certain proteins known to be biomarkers for aggressive breast cancer cells.

The old idea that cancer is less aggressive in the elderly is not entirely without merit: breast and prostate cancers tend to grow more slowly in older patients.

A team of researchers led by UC San Francisco scientists has identified a new drug target for triple - negative breast cancer, an aggressive disease subtype that has the poorest outcomes and accounts for as many as one in five cases.

«We found that PIM1 is indeed highly upregulated in these more aggressive breast cancers that have high MYC expression,» Goga said, «and that patients with high PIM1 tend to do more poorly.»

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

The panel also called for «aggressive research» on using RU486 and other drugs in the antiprogrestin class as contraceptives and as treat - ment for endometriosis, uter - ine fibroids, advanced breast cancer and meningioma brain tumours.

It has been recognized that the more aggressive triple - negative breast cancer occurs more frequently in African American women, but no previous study has examined racial differences in tumor genotype and how they might contribute to the risk of cancer recurrence.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the studIn addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the studin previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the Cancer Center, lead author of the study.

Although breast cancer is somewhat more aggressive in South Asian and Black women than in White women, this is largely due to age differences between ethnic groups in the UK, according to new research.

The results suggest that the pockets of stiffer extracellular matrix in the breasts of obese women contribute to tumor growth as well as to more aggressive cancers, Fischbach says: «People always think it's all about soluble factors, chemicals.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human breast cancer cells to take on aggressive, metastatic properties.

The team's findings, published online in Nature Cell Biology, explored HIF - 1's role in triple - negative breast cancer (TNBC), an aggressive and hard - to - treat form of the disease.

The growth rate of the cells exploded, and they quickly became disorganized masses characteristic of early stage, aggressive breast cancer, the team reports in the 7 February issue of the Journal of Experimental Medicine.

Further, the relationship between Myc and TXNIP is not observed in other types of breast cancer, suggesting that it is a feature of only aggressive triple negative breast cancers and not other less aggressive breast cancer types.

In the era of personalized cancer therapy, patients with TNBC remain at considerably higher risk of relapse and death than patients with other breast cancer subtypes, due to the aggressive nature of TNBC and the lack of newer targeted therapies for the disease.

Researchers led by Dr. Debra Auguste, associate professor, biomedical engineering, in the Grove School of Engineering at The City College of New York, have identified a molecule that could lead to developing treatment for one of the most aggressive forms of breast cancer.

Nuclear localization of KLF4 is associated with an aggressive phenotype in early - stage breast cancer

Like pervasive hypertension, some cancers, such as prostate and breast, tend to occur earlier and be more aggressive in blacks than whites, said Dr. Edward J. Kruse, chief of surgical oncology at MCG and the Georgia Cancer Center.

Mutations in the gene increase rat susceptibility to mammary cancer and FRY reduced the growth of highly aggressive human breast cancer cells.

«What we see over and over in trying to treat some of the most aggressive and intractable cancers, including many lung, brain, ovarian, breast, melanoma and sarcoma tumors, is that the tumor fights back.

«Inflammatory breast cancer is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast.

If validated in larger studies, this breakthrough could mean that it may be possible to identify those at the highest risk of their breast cancer spreading, with more aggressive treatments targeted specifically to them, while those at low risk could be spared treatments that may not benefit them, as well as the subsequent side - effects.

The aggressive basal - type breast cancers often metastasize, seeding new tumors in distant parts of the body.

A new score that could identify certain women with primary breast cancer in need of more or less aggressive treatments could play a pivotal role in ensuring they are given the best possible chance of survival, while only giving treatments such as chemotherapy when it's necessary.

Scientists exploit gene therapy to shrink tumors in mice with an aggressive form of breast cancer.

They are looking for protein indicators of aggressive breast cancer in the tissue and plasma samples.